MotifERR1.H12INVITRO.0.PSM.A
Gene (human)ESRRA
(GeneCards)
Gene synonyms (human)ERR1, ESRL1, NR3B1
Gene (mouse)Esrra
Gene synonyms (mouse)Err1, Estrra, Nr3b1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length11
ConsensusnbSAAGGTCAn
GC content49.37%
Information content (bits; total / per base)12.267 / 1.115
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9916

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 15 (99) 0.904 0.966 0.844 0.943 0.894 0.95 3.841 4.461 221.921 352.252
Mouse 5 (32) 0.902 0.972 0.796 0.939 0.893 0.973 3.598 5.256 201.386 341.509

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.976 0.971 0.817 0.828 0.669 0.7
best 0.999 0.999 0.999 0.998 0.996 0.995
Methyl HT-SELEX, 2 experiments median 0.997 0.995 0.989 0.985 0.926 0.929
best 0.999 0.999 0.999 0.998 0.996 0.995
Non-Methyl HT-SELEX, 6 experiments median 0.956 0.952 0.748 0.771 0.621 0.658
best 0.998 0.997 0.997 0.995 0.989 0.985

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.027 0.863 0.188 0.085
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familySteroid hormone receptors {2.1.1} (TFClass)
TF subfamilyER-like (NR3A) {2.1.1.2} (TFClass)
TFClass IDTFClass: 2.1.1.2.3
HGNCHGNC:3471
MGIMGI:1346831
EntrezGene (human)GeneID:2101
(SSTAR profile)
EntrezGene (mouse)GeneID:26379
(SSTAR profile)
UniProt ID (human)ERR1_HUMAN
UniProt ID (mouse)ERR1_MOUSE
UniProt AC (human)P11474
(TFClass)
UniProt AC (mouse)O08580
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 15 human, 5 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
011866.252355.253094.252600.25
021181.252271.251702.254761.25
031019.06049.02265.0583.0
049008.020.0711.0177.0
059881.05.026.04.0
060.00.09909.07.0
071.00.09915.00.0
08203.010.0480.09223.0
0978.08685.0531.0622.0
108050.25143.251609.25113.25
112469.52762.51303.53380.5
PFM
ACGT
010.1880.2380.3120.262
020.1190.2290.1720.48
030.1030.610.2280.059
040.9080.0020.0720.018
050.9960.0010.0030.0
060.00.00.9990.001
070.00.01.00.0
080.020.0010.0480.93
090.0080.8760.0540.063
100.8120.0140.1620.011
110.2490.2790.1310.341
PWM
ACGT
01-0.284-0.0510.2220.048
02-0.74-0.087-0.3750.652
03-0.8880.891-0.09-1.444
041.29-4.712-1.247-2.627
051.382-5.829-4.474-5.976
06-6.983-6.9831.385-5.586
07-6.622-6.9831.385-6.983
08-2.492-5.307-1.6381.313
09-3.4311.253-1.537-1.38
101.177-2.836-0.432-3.067
11-0.0040.108-0.6420.31
Standard thresholds
P-value Threshold
0.001 3.65376
0.0005 4.97259
0.0001 7.36307