ERR1.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERR1.H12INVITRO.0.PSM.A
Gene (human)	ESRRA (GeneCards)
Gene synonyms (human)	ERR1, ESRL1, NR3B1
Gene (mouse)	Esrra
Gene synonyms (mouse)	Err1, Estrra, Nr3b1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nbSAAGGTCAn
GC content	49.37%
Information content (bits; total / per base)	12.267 / 1.115
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9916

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	15 (99)	0.904	0.966	0.844	0.943	0.894	0.95	3.841	4.461	221.921	352.252
Mouse	5 (32)	0.902	0.972	0.796	0.939	0.893	0.973	3.598	5.256	201.386	341.509

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.976	0.971	0.817	0.828	0.669	0.7
Overall, 8 experiments	best	0.999	0.999	0.999	0.998	0.996	0.995
Methyl HT-SELEX, 2 experiments	median	0.997	0.995	0.989	0.985	0.926	0.929
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.999	0.998	0.996	0.995
Non-Methyl HT-SELEX, 6 experiments	median	0.956	0.952	0.748	0.771	0.621	0.658
Non-Methyl HT-SELEX, 6 experiments	best	0.998	0.997	0.997	0.995	0.989	0.985

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.027	0.863	0.188	0.085

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Steroid hormone receptors {2.1.1} (TFClass)
TF subfamily	ER-like (NR3A) {2.1.1.2} (TFClass)
TFClass ID	TFClass: 2.1.1.2.3
HGNC	HGNC:3471
MGI	MGI:1346831
EntrezGene (human)	GeneID:2101 (SSTAR profile)
EntrezGene (mouse)	GeneID:26379 (SSTAR profile)
UniProt ID (human)	ERR1_HUMAN
UniProt ID (mouse)	ERR1_MOUSE
UniProt AC (human)	P11474 (TFClass)
UniProt AC (mouse)	O08580 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	15 human, 5 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	ERR1.H12INVITRO.0.PSM.A.pcm
PWM	ERR1.H12INVITRO.0.PSM.A.pwm
PFM	ERR1.H12INVITRO.0.PSM.A.pfm
Alignment	ERR1.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	ERR1.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	ERR1.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	ERR1.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	ERR1.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	ERR1.H12INVITRO.0.PSM.A_homer_format_0.001.txt ERR1.H12INVITRO.0.PSM.A_homer_format_0.0005.txt ERR1.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1866.25	2355.25	3094.25	2600.25
02	1181.25	2271.25	1702.25	4761.25
03	1019.0	6049.0	2265.0	583.0
04	9008.0	20.0	711.0	177.0
05	9881.0	5.0	26.0	4.0
06	0.0	0.0	9909.0	7.0
07	1.0	0.0	9915.0	0.0
08	203.0	10.0	480.0	9223.0
09	78.0	8685.0	531.0	622.0
10	8050.25	143.25	1609.25	113.25
11	2469.5	2762.5	1303.5	3380.5

PFM

	A	C	G	T
01	0.188	0.238	0.312	0.262
02	0.119	0.229	0.172	0.48
03	0.103	0.61	0.228	0.059
04	0.908	0.002	0.072	0.018
05	0.996	0.001	0.003	0.0
06	0.0	0.0	0.999	0.001
07	0.0	0.0	1.0	0.0
08	0.02	0.001	0.048	0.93
09	0.008	0.876	0.054	0.063
10	0.812	0.014	0.162	0.011
11	0.249	0.279	0.131	0.341

PWM

	A	C	G	T
01	-0.284	-0.051	0.222	0.048
02	-0.74	-0.087	-0.375	0.652
03	-0.888	0.891	-0.09	-1.444
04	1.29	-4.712	-1.247	-2.627
05	1.382	-5.829	-4.474	-5.976
06	-6.983	-6.983	1.385	-5.586
07	-6.622	-6.983	1.385	-6.983
08	-2.492	-5.307	-1.638	1.313
09	-3.431	1.253	-1.537	-1.38
10	1.177	-2.836	-0.432	-3.067
11	-0.004	0.108	-0.642	0.31

Standard thresholds

P-value	Threshold
0.001	3.65376
0.0005	4.97259
0.0001	7.36307