ERG.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERG.H12RSNP.1.SM.B
Gene (human)	ERG (GeneCards)
Gene synonyms (human)
Gene (mouse)	Erg
Gene synonyms (mouse)	Erg-3
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	nWCCGGAAGTvn
GC content	56.34%
Information content (bits; total / per base)	14.686 / 1.224
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2374

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	42 (221)	0.879	0.954	0.804	0.931	0.829	0.933	2.682	4.458	133.553	417.959
Mouse	11 (64)	0.924	0.972	0.843	0.937	0.889	0.96	3.356	4.447	239.886	465.347

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.988	0.981	0.887	0.895	0.705	0.744
Overall, 10 experiments	best	0.999	0.998	0.995	0.992	0.989	0.984
Methyl HT-SELEX, 3 experiments	median	0.803	0.761	0.65	0.651	0.568	0.587
Methyl HT-SELEX, 3 experiments	best	0.817	0.776	0.679	0.67	0.589	0.602
Non-Methyl HT-SELEX, 7 experiments	median	0.992	0.986	0.945	0.933	0.763	0.788
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.995	0.992	0.989	0.984

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	5.42	11.836	0.231	0.194

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.865	0.698	0.846	0.532
batch 2	0.905	0.784	0.864	0.597

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.7
HGNC	HGNC:3446
MGI	MGI:95415
EntrezGene (human)	GeneID:2078 (SSTAR profile)
EntrezGene (mouse)	GeneID:13876 (SSTAR profile)
UniProt ID (human)	ERG_HUMAN
UniProt ID (mouse)	ERG_MOUSE
UniProt AC (human)	P11308 (TFClass)
UniProt AC (mouse)	P81270 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	42 human, 11 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ERG.H12RSNP.1.SM.B.pcm
PWM	ERG.H12RSNP.1.SM.B.pwm
PFM	ERG.H12RSNP.1.SM.B.pfm
Alignment	ERG.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	ERG.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	ERG.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	ERG.H12RSNP.1.SM.B_meme_format.meme
Transfac format	ERG.H12RSNP.1.SM.B_transfac_format.txt
Homer format	ERG.H12RSNP.1.SM.B_homer_format_0.001.txt ERG.H12RSNP.1.SM.B_homer_format_0.0005.txt ERG.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	670.5	609.5	427.5	666.5
02	1619.25	16.25	253.25	485.25
03	21.0	2250.0	101.0	2.0
04	83.0	2291.0	0.0	0.0
05	0.0	0.0	2374.0	0.0
06	0.0	0.0	2374.0	0.0
07	2374.0	0.0	0.0	0.0
08	2326.0	0.0	0.0	48.0
09	591.0	2.0	1781.0	0.0
10	2.0	580.0	50.0	1742.0
11	698.25	282.25	1187.25	206.25
12	543.0	832.0	638.0	361.0

PFM

	A	C	G	T
01	0.282	0.257	0.18	0.281
02	0.682	0.007	0.107	0.204
03	0.009	0.948	0.043	0.001
04	0.035	0.965	0.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.98	0.0	0.0	0.02
09	0.249	0.001	0.75	0.0
10	0.001	0.244	0.021	0.734
11	0.294	0.119	0.5	0.087
12	0.229	0.35	0.269	0.152

PWM

	A	C	G	T
01	0.122	0.027	-0.327	0.116
02	1.002	-3.488	-0.847	-0.201
03	-3.256	1.33	-1.755	-5.017
04	-1.947	1.348	-5.725	-5.725
05	-5.725	-5.725	1.384	-5.725
06	-5.725	-5.725	1.384	-5.725
07	1.384	-5.725	-5.725	-5.725
08	1.363	-5.725	-5.725	-2.478
09	-0.004	-5.017	1.097	-5.725
10	-5.017	-0.023	-2.439	1.075
11	0.162	-0.74	0.692	-1.051
12	-0.089	0.337	0.072	-0.495

Standard thresholds

P-value	Threshold
0.001	1.527075
0.0005	3.06824
0.0001	6.349095