ERG.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERG.H12RSNP.0.P.B
Gene (human)	ERG (GeneCards)
Gene synonyms (human)
Gene (mouse)	Erg
Gene synonyms (mouse)	Erg-3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	dCCGGAARYvvv
GC content	60.78%
Information content (bits; total / per base)	12.567 / 1.047
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	42 (221)	0.885	0.957	0.809	0.915	0.86	0.949	3.071	4.519	146.201	466.013
Mouse	11 (64)	0.924	0.972	0.846	0.937	0.912	0.964	3.562	4.564	268.829	471.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.969	0.957	0.879	0.875	0.703	0.736
Overall, 10 experiments	best	0.997	0.996	0.993	0.989	0.985	0.978
Methyl HT-SELEX, 3 experiments	median	0.77	0.746	0.616	0.631	0.541	0.57
Methyl HT-SELEX, 3 experiments	best	0.808	0.765	0.67	0.662	0.585	0.597
Non-Methyl HT-SELEX, 7 experiments	median	0.987	0.979	0.926	0.917	0.752	0.773
Non-Methyl HT-SELEX, 7 experiments	best	0.997	0.996	0.993	0.989	0.985	0.978

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	8.354	16.823	0.224	0.195

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.867	0.611	0.844	0.54
batch 2	0.894	0.701	0.869	0.642

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.7
HGNC	HGNC:3446
MGI	MGI:95415
EntrezGene (human)	GeneID:2078 (SSTAR profile)
EntrezGene (mouse)	GeneID:13876 (SSTAR profile)
UniProt ID (human)	ERG_HUMAN
UniProt ID (mouse)	ERG_MOUSE
UniProt AC (human)	P11308 (TFClass)
UniProt AC (mouse)	P81270 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	42 human, 11 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ERG.H12RSNP.0.P.B.pcm
PWM	ERG.H12RSNP.0.P.B.pwm
PFM	ERG.H12RSNP.0.P.B.pfm
Alignment	ERG.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	ERG.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	ERG.H12RSNP.0.P.B_jaspar_format.txt
MEME format	ERG.H12RSNP.0.P.B_meme_format.meme
Transfac format	ERG.H12RSNP.0.P.B_transfac_format.txt
Homer format	ERG.H12RSNP.0.P.B_homer_format_0.001.txt ERG.H12RSNP.0.P.B_homer_format_0.0005.txt ERG.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	460.0	99.0	325.0	116.0
02	114.0	808.0	74.0	4.0
03	308.0	685.0	2.0	5.0
04	0.0	2.0	990.0	8.0
05	2.0	0.0	998.0	0.0
06	999.0	0.0	1.0	0.0
07	981.0	0.0	1.0	18.0
08	275.0	5.0	695.0	25.0
09	35.0	324.0	52.0	589.0
10	138.0	165.0	599.0	98.0
11	231.0	265.0	413.0	91.0
12	128.0	449.0	342.0	81.0

PFM

	A	C	G	T
01	0.46	0.099	0.325	0.116
02	0.114	0.808	0.074	0.004
03	0.308	0.685	0.002	0.005
04	0.0	0.002	0.99	0.008
05	0.002	0.0	0.998	0.0
06	0.999	0.0	0.001	0.0
07	0.981	0.0	0.001	0.018
08	0.275	0.005	0.695	0.025
09	0.035	0.324	0.052	0.589
10	0.138	0.165	0.599	0.098
11	0.231	0.265	0.413	0.091
12	0.128	0.449	0.342	0.081

PWM

	A	C	G	T
01	0.607	-0.916	0.261	-0.76
02	-0.777	1.168	-1.201	-3.783
03	0.207	1.004	-4.213	-3.622
04	-4.982	-4.213	1.371	-3.253
05	-4.213	-4.982	1.379	-4.982
06	1.38	-4.982	-4.525	-4.982
07	1.362	-4.982	-4.525	-2.546
08	0.095	-3.622	1.018	-2.243
09	-1.925	0.258	-1.544	0.853
10	-0.589	-0.412	0.87	-0.926
11	-0.078	0.058	0.499	-0.999
12	-0.663	0.583	0.312	-1.113

Standard thresholds

P-value	Threshold
0.001	3.581615
0.0005	4.856125
0.0001	7.404295