ERG.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERG.H12INVIVO.1.SM.B
Gene (human)	ERG (GeneCards)
Gene synonyms (human)
Gene (mouse)	Erg
Gene synonyms (mouse)	Erg-3
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	nRCCGGAAGTvn
GC content	56.11%
Information content (bits; total / per base)	14.173 / 1.181
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9619

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	42 (221)	0.886	0.955	0.808	0.932	0.839	0.937	2.721	4.49	138.658	432.347
Mouse	11 (64)	0.925	0.974	0.846	0.941	0.899	0.962	3.394	4.473	256.789	475.26

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.991	0.985	0.888	0.897	0.706	0.745
Overall, 10 experiments	best	0.999	0.998	0.996	0.995	0.99	0.986
Methyl HT-SELEX, 3 experiments	median	0.807	0.767	0.653	0.655	0.568	0.588
Methyl HT-SELEX, 3 experiments	best	0.82	0.78	0.68	0.672	0.59	0.603
Non-Methyl HT-SELEX, 7 experiments	median	0.993	0.989	0.953	0.944	0.765	0.793
Non-Methyl HT-SELEX, 7 experiments	best	0.999	0.998	0.996	0.995	0.99	0.986

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	5.903	12.956	0.236	0.197

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.864	0.702	0.833	0.532
batch 2	0.897	0.768	0.869	0.615

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.7
HGNC	HGNC:3446
MGI	MGI:95415
EntrezGene (human)	GeneID:2078 (SSTAR profile)
EntrezGene (mouse)	GeneID:13876 (SSTAR profile)
UniProt ID (human)	ERG_HUMAN
UniProt ID (mouse)	ERG_MOUSE
UniProt AC (human)	P11308 (TFClass)
UniProt AC (mouse)	P81270 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	42 human, 11 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ERG.H12INVIVO.1.SM.B.pcm
PWM	ERG.H12INVIVO.1.SM.B.pwm
PFM	ERG.H12INVIVO.1.SM.B.pfm
Alignment	ERG.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	ERG.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	ERG.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	ERG.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	ERG.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	ERG.H12INVIVO.1.SM.B_homer_format_0.001.txt ERG.H12INVIVO.1.SM.B_homer_format_0.0005.txt ERG.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2799.25	2631.25	1921.25	2267.25
02	6972.0	79.0	1285.0	1283.0
03	137.0	8956.0	522.0	4.0
04	432.0	9187.0	0.0	0.0
05	0.0	0.0	9619.0	0.0
06	0.0	0.0	9619.0	0.0
07	9619.0	0.0	0.0	0.0
08	8895.0	0.0	0.0	724.0
09	3113.0	1.0	6503.0	2.0
10	24.0	2152.0	293.0	7150.0
11	2759.0	1708.0	4297.0	855.0
12	2296.75	3394.75	2593.75	1333.75

PFM

	A	C	G	T
01	0.291	0.274	0.2	0.236
02	0.725	0.008	0.134	0.133
03	0.014	0.931	0.054	0.0
04	0.045	0.955	0.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	0.925	0.0	0.0	0.075
09	0.324	0.0	0.676	0.0
10	0.002	0.224	0.03	0.743
11	0.287	0.178	0.447	0.089
12	0.239	0.353	0.27	0.139

PWM

	A	C	G	T
01	0.152	0.09	-0.224	-0.059
02	1.064	-3.388	-0.626	-0.627
03	-2.85	1.314	-1.524	-5.947
04	-1.712	1.34	-6.956	-6.956
05	-6.956	-6.956	1.386	-6.956
06	-6.956	-6.956	1.386	-6.956
07	1.386	-6.956	-6.956	-6.956
08	1.307	-6.956	-6.956	-1.198
09	0.258	-6.594	0.994	-6.329
10	-4.517	-0.111	-2.098	1.089
11	0.137	-0.342	0.58	-1.032
12	-0.046	0.345	0.076	-0.589

Standard thresholds

P-value	Threshold
0.001	1.186835
0.0005	3.017635
0.0001	6.77267