ERG.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERG.H12INVITRO.0.P.B
Gene (human)	ERG (GeneCards)
Gene synonyms (human)
Gene (mouse)	Erg
Gene synonyms (mouse)	Erg-3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	vRCCGGAAGYRv
GC content	58.75%
Information content (bits; total / per base)	13.225 / 1.102
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	42 (221)	0.887	0.957	0.809	0.922	0.863	0.95	3.112	4.694	147.538	465.699
Mouse	11 (64)	0.927	0.973	0.847	0.94	0.919	0.967	3.636	4.651	269.899	471.194

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.982	0.974	0.886	0.889	0.709	0.743
Overall, 10 experiments	best	0.998	0.997	0.994	0.991	0.987	0.982
Methyl HT-SELEX, 3 experiments	median	0.808	0.775	0.653	0.658	0.562	0.588
Methyl HT-SELEX, 3 experiments	best	0.818	0.777	0.68	0.67	0.593	0.604
Non-Methyl HT-SELEX, 7 experiments	median	0.99	0.983	0.933	0.921	0.756	0.779
Non-Methyl HT-SELEX, 7 experiments	best	0.998	0.997	0.994	0.991	0.987	0.982

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	7.367	15.808	0.228	0.201

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.864	0.617	0.843	0.532
batch 2	0.877	0.661	0.872	0.645

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.7
HGNC	HGNC:3446
MGI	MGI:95415
EntrezGene (human)	GeneID:2078 (SSTAR profile)
EntrezGene (mouse)	GeneID:13876 (SSTAR profile)
UniProt ID (human)	ERG_HUMAN
UniProt ID (mouse)	ERG_MOUSE
UniProt AC (human)	P11308 (TFClass)
UniProt AC (mouse)	P81270 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	42 human, 11 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ERG.H12INVITRO.0.P.B.pcm
PWM	ERG.H12INVITRO.0.P.B.pwm
PFM	ERG.H12INVITRO.0.P.B.pfm
Alignment	ERG.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	ERG.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	ERG.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	ERG.H12INVITRO.0.P.B_meme_format.meme
Transfac format	ERG.H12INVITRO.0.P.B_transfac_format.txt
Homer format	ERG.H12INVITRO.0.P.B_homer_format_0.001.txt ERG.H12INVITRO.0.P.B_homer_format_0.0005.txt ERG.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	297.0	271.0	323.0	109.0
02	565.0	62.0	291.0	82.0
03	67.0	850.0	80.0	3.0
04	243.0	746.0	3.0	8.0
05	4.0	0.0	995.0	1.0
06	0.0	0.0	1000.0	0.0
07	999.0	0.0	1.0	0.0
08	980.0	0.0	0.0	20.0
09	226.0	6.0	765.0	3.0
10	18.0	254.0	49.0	679.0
11	171.0	139.0	609.0	81.0
12	307.0	250.0	356.0	87.0

PFM

	A	C	G	T
01	0.297	0.271	0.323	0.109
02	0.565	0.062	0.291	0.082
03	0.067	0.85	0.08	0.003
04	0.243	0.746	0.003	0.008
05	0.004	0.0	0.995	0.001
06	0.0	0.0	1.0	0.0
07	0.999	0.0	0.001	0.0
08	0.98	0.0	0.0	0.02
09	0.226	0.006	0.765	0.003
10	0.018	0.254	0.049	0.679
11	0.171	0.139	0.609	0.081
12	0.307	0.25	0.356	0.087

PWM

	A	C	G	T
01	0.171	0.08	0.255	-0.821
02	0.812	-1.374	0.151	-1.101
03	-1.298	1.219	-1.125	-3.975
04	-0.028	1.089	-3.975	-3.253
05	-3.783	-4.982	1.376	-4.525
06	-4.982	-4.982	1.381	-4.982
07	1.38	-4.982	-4.525	-4.982
08	1.361	-4.982	-4.982	-2.45
09	-0.1	-3.484	1.114	-3.975
10	-2.546	0.016	-1.602	0.995
11	-0.377	-0.582	0.886	-1.113
12	0.204	0.0	0.351	-1.043

Standard thresholds

P-value	Threshold
0.001	3.22073
0.0005	4.520465
0.0001	7.23814