ERG.H12CORE.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ERG.H12CORE.0.P.B
Gene (human)	ERG (GeneCards)
Gene synonyms (human)
Gene (mouse)	Erg
Gene synonyms (mouse)	Erg-3
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	RCCGGAAGYRvv
GC content	58.74%
Information content (bits; total / per base)	12.934 / 1.078
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	42 (221)	0.887	0.955	0.808	0.92	0.865	0.949	3.113	4.72	146.432	463.398
Mouse	11 (64)	0.924	0.973	0.847	0.939	0.917	0.966	3.634	4.67	270.048	466.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.98	0.97	0.883	0.884	0.709	0.742
Overall, 10 experiments	best	0.998	0.997	0.994	0.99	0.987	0.981
Methyl HT-SELEX, 3 experiments	median	0.775	0.753	0.62	0.635	0.544	0.573
Methyl HT-SELEX, 3 experiments	best	0.812	0.77	0.674	0.665	0.589	0.6
Non-Methyl HT-SELEX, 7 experiments	median	0.989	0.981	0.929	0.92	0.755	0.777
Non-Methyl HT-SELEX, 7 experiments	best	0.998	0.997	0.994	0.99	0.987	0.981

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	7.79	16.26	0.22	0.197

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.861	0.606	0.841	0.526
batch 2	0.901	0.69	0.87	0.656

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ETS-like {3.5.2.1} (TFClass)
TFClass ID	TFClass: 3.5.2.1.7
HGNC	HGNC:3446
MGI	MGI:95415
EntrezGene (human)	GeneID:2078 (SSTAR profile)
EntrezGene (mouse)	GeneID:13876 (SSTAR profile)
UniProt ID (human)	ERG_HUMAN
UniProt ID (mouse)	ERG_MOUSE
UniProt AC (human)	P11308 (TFClass)
UniProt AC (mouse)	P81270 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	42 human, 11 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	ERG.H12CORE.0.P.B.pcm
PWM	ERG.H12CORE.0.P.B.pwm
PFM	ERG.H12CORE.0.P.B.pfm
Alignment	ERG.H12CORE.0.P.B.words.tsv
Threshold to P-value map	ERG.H12CORE.0.P.B.thr
Motif in other formats
JASPAR format	ERG.H12CORE.0.P.B_jaspar_format.txt
MEME format	ERG.H12CORE.0.P.B_meme_format.meme
Transfac format	ERG.H12CORE.0.P.B_transfac_format.txt
Homer format	ERG.H12CORE.0.P.B_homer_format_0.001.txt ERG.H12CORE.0.P.B_homer_format_0.0005.txt ERG.H12CORE.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	560.0	74.0	277.0	89.0
02	64.0	839.0	93.0	4.0
03	262.0	722.0	2.0	14.0
04	2.0	0.0	996.0	2.0
05	4.0	1.0	995.0	0.0
06	998.0	0.0	2.0	0.0
07	977.0	0.0	0.0	23.0
08	221.0	7.0	759.0	13.0
09	25.0	261.0	44.0	670.0
10	185.0	125.0	599.0	91.0
11	331.0	229.0	355.0	85.0
12	215.0	364.0	305.0	116.0

PFM

	A	C	G	T
01	0.56	0.074	0.277	0.089
02	0.064	0.839	0.093	0.004
03	0.262	0.722	0.002	0.014
04	0.002	0.0	0.996	0.002
05	0.004	0.001	0.995	0.0
06	0.998	0.0	0.002	0.0
07	0.977	0.0	0.0	0.023
08	0.221	0.007	0.759	0.013
09	0.025	0.261	0.044	0.67
10	0.185	0.125	0.599	0.091
11	0.331	0.229	0.355	0.085
12	0.215	0.364	0.305	0.116

PWM

	A	C	G	T
01	0.803	-1.201	0.102	-1.02
02	-1.343	1.206	-0.977	-3.783
03	0.047	1.056	-4.213	-2.773
04	-4.213	-4.982	1.377	-4.213
05	-3.783	-4.525	1.376	-4.982
06	1.379	-4.982	-4.213	-4.982
07	1.358	-4.982	-4.982	-2.32
08	-0.122	-3.362	1.106	-2.839
09	-2.243	0.043	-1.706	0.982
10	-0.299	-0.686	0.87	-0.999
11	0.279	-0.087	0.349	-1.066
12	-0.15	0.374	0.198	-0.76

Standard thresholds

P-value	Threshold
0.001	3.458565
0.0005	4.71017
0.0001	7.260415