EPAS1.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EPAS1.H12RSNP.0.P.B
Gene (human)	EPAS1 (GeneCards)
Gene synonyms (human)	BHLHE73, HIF2A, MOP2, PASD2
Gene (mouse)	Epas1
Gene synonyms (mouse)	Hif2a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	vbdbvKACGTGMMn
GC content	56.47%
Information content (bits; total / per base)	11.499 / 0.821
Data sources	ChIP-Seq
Aligned words	95

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (90)	0.826	0.887	0.75	0.823	0.804	0.874	3.025	3.838	146.549	322.699

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	28.417	8.124	0.489	0.375

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	PAS {1.2.5} (TFClass)
TF subfamily	PAS-AHR {1.2.5.1} (TFClass)
TFClass ID	TFClass: 1.2.5.1.7
HGNC	HGNC:3374
MGI	MGI:109169
EntrezGene (human)	GeneID:2034 (SSTAR profile)
EntrezGene (mouse)	GeneID:13819 (SSTAR profile)
UniProt ID (human)	EPAS1_HUMAN
UniProt ID (mouse)	EPAS1_MOUSE
UniProt AC (human)	Q99814 (TFClass)
UniProt AC (mouse)	P97481 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 0 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	EPAS1.H12RSNP.0.P.B.pcm
PWM	EPAS1.H12RSNP.0.P.B.pwm
PFM	EPAS1.H12RSNP.0.P.B.pfm
Alignment	EPAS1.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	EPAS1.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	EPAS1.H12RSNP.0.P.B_jaspar_format.txt
MEME format	EPAS1.H12RSNP.0.P.B_meme_format.meme
Transfac format	EPAS1.H12RSNP.0.P.B_transfac_format.txt
Homer format	EPAS1.H12RSNP.0.P.B_homer_format_0.001.txt EPAS1.H12RSNP.0.P.B_homer_format_0.0005.txt EPAS1.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	18.0	20.0	46.0	11.0
02	14.0	15.0	36.0	30.0
03	14.0	12.0	46.0	23.0
04	15.0	17.0	42.0	21.0
05	21.0	30.0	39.0	5.0
06	15.0	4.0	18.0	58.0
07	89.0	4.0	2.0	0.0
08	1.0	87.0	3.0	4.0
09	1.0	1.0	93.0	0.0
10	0.0	0.0	1.0	94.0
11	0.0	0.0	95.0	0.0
12	54.0	36.0	1.0	4.0
13	15.0	59.0	9.0	12.0
14	26.0	13.0	22.0	34.0

PFM

	A	C	G	T
01	0.189	0.211	0.484	0.116
02	0.147	0.158	0.379	0.316
03	0.147	0.126	0.484	0.242
04	0.158	0.179	0.442	0.221
05	0.221	0.316	0.411	0.053
06	0.158	0.042	0.189	0.611
07	0.937	0.042	0.021	0.0
08	0.011	0.916	0.032	0.042
09	0.011	0.011	0.979	0.0
10	0.0	0.0	0.011	0.989
11	0.0	0.0	1.0	0.0
12	0.568	0.379	0.011	0.042
13	0.158	0.621	0.095	0.126
14	0.274	0.137	0.232	0.358

PWM

	A	C	G	T
01	-0.263	-0.163	0.639	-0.718
02	-0.497	-0.433	0.4	0.224
03	-0.497	-0.639	0.639	-0.031
04	-0.433	-0.316	0.55	-0.117
05	-0.117	0.224	0.478	-1.4
06	-0.433	-1.578	-0.263	0.865
07	1.287	-1.578	-2.071	-3.085
08	-2.454	1.265	-1.794	-1.578
09	-2.454	-2.454	1.33	-3.085
10	-3.085	-3.085	-2.454	1.341
11	-3.085	-3.085	1.351	-3.085
12	0.795	0.4	-2.454	-1.578
13	-0.433	0.882	-0.898	-0.639
14	0.087	-0.566	-0.073	0.345

Standard thresholds

P-value	Threshold
0.001	4.62356
0.0005	5.50396
0.0001	7.358815