EPAS1.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EPAS1.H12INVIVO.0.P.B
Gene (human)	EPAS1 (GeneCards)
Gene synonyms (human)	BHLHE73, HIF2A, MOP2, PASD2
Gene (mouse)	Epas1
Gene synonyms (mouse)	Hif2a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	9
Consensus	vKRCGTGhh
GC content	58.73%
Information content (bits; total / per base)	9.273 / 1.03
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (90)	0.854	0.92	0.776	0.861	0.822	0.912	3.002	3.674	186.538	417.108

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	28.417	8.124	0.45	0.357

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	PAS {1.2.5} (TFClass)
TF subfamily	PAS-AHR {1.2.5.1} (TFClass)
TFClass ID	TFClass: 1.2.5.1.7
HGNC	HGNC:3374
MGI	MGI:109169
EntrezGene (human)	GeneID:2034 (SSTAR profile)
EntrezGene (mouse)	GeneID:13819 (SSTAR profile)
UniProt ID (human)	EPAS1_HUMAN
UniProt ID (mouse)	EPAS1_MOUSE
UniProt AC (human)	Q99814 (TFClass)
UniProt AC (mouse)	P97481 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 0 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	EPAS1.H12INVIVO.0.P.B.pcm
PWM	EPAS1.H12INVIVO.0.P.B.pwm
PFM	EPAS1.H12INVIVO.0.P.B.pfm
Alignment	EPAS1.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	EPAS1.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	EPAS1.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	EPAS1.H12INVIVO.0.P.B_meme_format.meme
Transfac format	EPAS1.H12INVIVO.0.P.B_transfac_format.txt
Homer format	EPAS1.H12INVIVO.0.P.B_homer_format_0.001.txt EPAS1.H12INVIVO.0.P.B_homer_format_0.0005.txt EPAS1.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	210.0	259.0	454.0	77.0
02	136.0	47.0	261.0	556.0
03	757.0	58.0	142.0	43.0
04	7.0	955.0	2.0	36.0
05	11.0	6.0	971.0	12.0
06	1.0	0.0	1.0	998.0
07	0.0	1.0	990.0	9.0
08	339.0	457.0	78.0	126.0
09	194.0	436.0	168.0	202.0

PFM

	A	C	G	T
01	0.21	0.259	0.454	0.077
02	0.136	0.047	0.261	0.556
03	0.757	0.058	0.142	0.043
04	0.007	0.955	0.002	0.036
05	0.011	0.006	0.971	0.012
06	0.001	0.0	0.001	0.998
07	0.0	0.001	0.99	0.009
08	0.339	0.457	0.078	0.126
09	0.194	0.436	0.168	0.202

PWM

	A	C	G	T
01	-0.173	0.035	0.594	-1.162
02	-0.603	-1.642	0.043	0.796
03	1.103	-1.439	-0.56	-1.728
04	-3.362	1.335	-4.213	-1.898
05	-2.985	-3.484	1.352	-2.909
06	-4.525	-4.982	-4.525	1.379
07	-4.982	-4.525	1.371	-3.156
08	0.303	0.6	-1.15	-0.678
09	-0.252	0.553	-0.394	-0.212

Standard thresholds

P-value	Threshold
0.001	5.09449
0.0005	5.99171
0.0001	7.445355