EPAS1.H12INVITRO.0.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	EPAS1.H12INVITRO.0.P.D
Gene (human)	EPAS1 (GeneCards)
Gene synonyms (human)	BHLHE73, HIF2A, MOP2, PASD2
Gene (mouse)	Epas1
Gene synonyms (mouse)	Hif2a
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	11
Consensus	dvvdACGTGMh
GC content	59.69%
Information content (bits; total / per base)	9.674 / 0.879
Data sources	ChIP-Seq
Aligned words	1013

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	14 (90)	0.857	0.921	0.781	0.855	0.825	0.915	3.074	3.78	189.988	381.292

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	28.417	8.124	0.474	0.384

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	PAS {1.2.5} (TFClass)
TF subfamily	PAS-AHR {1.2.5.1} (TFClass)
TFClass ID	TFClass: 1.2.5.1.7
HGNC	HGNC:3374
MGI	MGI:109169
EntrezGene (human)	GeneID:2034 (SSTAR profile)
EntrezGene (mouse)	GeneID:13819 (SSTAR profile)
UniProt ID (human)	EPAS1_HUMAN
UniProt ID (mouse)	EPAS1_MOUSE
UniProt AC (human)	Q99814 (TFClass)
UniProt AC (mouse)	P97481 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	14 human, 0 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	EPAS1.H12INVITRO.0.P.D.pcm
PWM	EPAS1.H12INVITRO.0.P.D.pwm
PFM	EPAS1.H12INVITRO.0.P.D.pfm
Alignment	EPAS1.H12INVITRO.0.P.D.words.tsv
Threshold to P-value map	EPAS1.H12INVITRO.0.P.D.thr
Motif in other formats
JASPAR format	EPAS1.H12INVITRO.0.P.D_jaspar_format.txt
MEME format	EPAS1.H12INVITRO.0.P.D_meme_format.meme
Transfac format	EPAS1.H12INVITRO.0.P.D_transfac_format.txt
Homer format	EPAS1.H12INVITRO.0.P.D_homer_format_0.001.txt EPAS1.H12INVITRO.0.P.D_homer_format_0.0005.txt EPAS1.H12INVITRO.0.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	160.0	130.0	446.0	277.0
02	207.0	195.0	433.0	178.0
03	230.0	233.0	470.0	80.0
04	164.0	117.0	263.0	469.0
05	798.0	30.0	171.0	14.0
06	7.0	966.0	6.0	34.0
07	47.0	4.0	959.0	3.0
08	1.0	2.0	1.0	1009.0
09	0.0	0.0	1013.0	0.0
10	357.0	511.0	50.0	95.0
11	171.0	490.0	161.0	191.0

PFM

	A	C	G	T
01	0.158	0.128	0.44	0.273
02	0.204	0.192	0.427	0.176
03	0.227	0.23	0.464	0.079
04	0.162	0.115	0.26	0.463
05	0.788	0.03	0.169	0.014
06	0.007	0.954	0.006	0.034
07	0.046	0.004	0.947	0.003
08	0.001	0.002	0.001	0.996
09	0.0	0.0	1.0	0.0
10	0.352	0.504	0.049	0.094
11	0.169	0.484	0.159	0.189

PWM

	A	C	G	T
01	-0.455	-0.66	0.563	0.089
02	-0.2	-0.259	0.534	-0.35
03	-0.096	-0.083	0.615	-1.138
04	-0.431	-0.764	0.038	0.613
05	1.143	-2.084	-0.389	-2.786
06	-3.374	1.334	-3.496	-1.965
07	-1.655	-3.795	1.327	-3.987
08	-4.537	-4.225	-4.537	1.377
09	-4.993	-4.993	1.381	-4.993
10	0.341	0.699	-1.595	-0.969
11	-0.389	0.657	-0.449	-0.28

Standard thresholds

P-value	Threshold
0.001	5.004535
0.0005	5.95634
0.0001	7.470485