ELF2.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ELF2.H12INVITRO.0.PS.A
Gene (human)	ELF2 (GeneCards)
Gene synonyms (human)	NERF
Gene (mouse)	Elf2
Gene synonyms (mouse)	Nerf
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	nhWMCCGGAAGTRn
GC content	54.3%
Information content (bits; total / per base)	18.363 / 1.312
Data sources	ChIP-Seq + HT-SELEX
Aligned words	2497

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (11)	0.873	0.924	0.818	0.867	0.841	0.904	3.357	3.933	30.678	65.523

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 5 experiments	median	0.998	0.998	0.995	0.992	0.983	0.977
Overall, 5 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.998	0.996	0.992	0.989	0.918	0.922
Methyl HT-SELEX, 2 experiments	best	0.998	0.998	0.995	0.992	0.983	0.977
Non-Methyl HT-SELEX, 3 experiments	median	0.999	0.998	0.998	0.997	0.994	0.992
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.985	0.755	0.971	0.629
batch 2	0.866	0.684	0.888	0.653

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ELF1-like {3.5.2.3} (TFClass)
TFClass ID	TFClass: 3.5.2.3.2
HGNC	HGNC:3317
MGI	MGI:1916507
EntrezGene (human)	GeneID:1998 (SSTAR profile)
EntrezGene (mouse)	GeneID:69257 (SSTAR profile)
UniProt ID (human)	ELF2_HUMAN
UniProt ID (mouse)	ELF2_MOUSE
UniProt AC (human)	Q15723 (TFClass)
UniProt AC (mouse)	Q9JHC9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	2

PCM	ELF2.H12INVITRO.0.PS.A.pcm
PWM	ELF2.H12INVITRO.0.PS.A.pwm
PFM	ELF2.H12INVITRO.0.PS.A.pfm
Alignment	ELF2.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	ELF2.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	ELF2.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	ELF2.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	ELF2.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	ELF2.H12INVITRO.0.PS.A_homer_format_0.001.txt ELF2.H12INVITRO.0.PS.A_homer_format_0.0005.txt ELF2.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	727.25	791.25	600.25	378.25
02	1355.5	387.5	212.5	541.5
03	1883.0	77.0	49.0	488.0
04	331.0	1822.0	20.0	324.0
05	16.0	2382.0	98.0	1.0
06	3.0	2492.0	2.0	0.0
07	0.0	0.0	2497.0	0.0
08	0.0	0.0	2497.0	0.0
09	2496.0	0.0	0.0	1.0
10	2497.0	0.0	0.0	0.0
11	7.0	0.0	2490.0	0.0
12	4.0	27.0	1.0	2465.0
13	1205.0	91.0	1089.0	112.0
14	751.75	776.75	578.75	389.75

PFM

	A	C	G	T
01	0.291	0.317	0.24	0.151
02	0.543	0.155	0.085	0.217
03	0.754	0.031	0.02	0.195
04	0.133	0.73	0.008	0.13
05	0.006	0.954	0.039	0.0
06	0.001	0.998	0.001	0.0
07	0.0	0.0	1.0	0.0
08	0.0	0.0	1.0	0.0
09	1.0	0.0	0.0	0.0
10	1.0	0.0	0.0	0.0
11	0.003	0.0	0.997	0.0
12	0.002	0.011	0.0	0.987
13	0.483	0.036	0.436	0.045
14	0.301	0.311	0.232	0.156

PWM

	A	C	G	T
01	0.152	0.236	-0.039	-0.499
02	0.774	-0.475	-1.072	-0.142
03	1.102	-2.071	-2.509	-0.245
04	-0.632	1.069	-3.351	-0.653
05	-3.552	1.337	-1.835	-5.356
06	-4.839	1.382	-5.065	-5.769
07	-5.769	-5.769	1.384	-5.769
08	-5.769	-5.769	1.384	-5.769
09	1.384	-5.769	-5.769	-5.356
10	1.384	-5.769	-5.769	-5.769
11	-4.247	-5.769	1.381	-5.769
12	-4.655	-3.074	-5.356	1.371
13	0.656	-1.908	0.555	-1.704
14	0.185	0.218	-0.075	-0.469

Standard thresholds

P-value	Threshold
0.001	-1.89804
0.0005	-0.08779
0.0001	3.93971