ELF2.H12CORE.1.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ELF2.H12CORE.1.M.B
Gene (human)	ELF2 (GeneCards)
Gene synonyms (human)	NERF
Gene (mouse)	Elf2
Gene synonyms (mouse)	Nerf
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	ddnSMGGAAGTdn
GC content	48.85%
Information content (bits; total / per base)	13.788 / 1.061
Data sources	Methyl-HT-SELEX
Aligned words	9397

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (11)	0.852	0.913	0.766	0.787	0.865	0.94	3.346	4.155	27.854	74.149

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 5 experiments	median	0.998	0.997	0.997	0.994	0.988	0.985
Overall, 5 experiments	best	1.0	0.999	1.0	0.999	0.999	0.998
Methyl HT-SELEX, 2 experiments	median	0.999	0.998	0.995	0.993	0.921	0.929
Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.997	0.995	0.988	0.985
Non-Methyl HT-SELEX, 3 experiments	median	0.998	0.996	0.997	0.994	0.992	0.989
Non-Methyl HT-SELEX, 3 experiments	best	1.0	0.999	1.0	0.999	0.999	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.958	0.575	0.936	0.593
batch 2	0.889	0.698	0.883	0.648

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Tryptophan cluster factors {3.5} (TFClass)
TF family	Ets-related {3.5.2} (TFClass)
TF subfamily	ELF1-like {3.5.2.3} (TFClass)
TFClass ID	TFClass: 3.5.2.3.2
HGNC	HGNC:3317
MGI	MGI:1916507
EntrezGene (human)	GeneID:1998 (SSTAR profile)
EntrezGene (mouse)	GeneID:69257 (SSTAR profile)
UniProt ID (human)	ELF2_HUMAN
UniProt ID (mouse)	ELF2_MOUSE
UniProt AC (human)	Q15723 (TFClass)
UniProt AC (mouse)	Q9JHC9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	2

PCM	ELF2.H12CORE.1.M.B.pcm
PWM	ELF2.H12CORE.1.M.B.pwm
PFM	ELF2.H12CORE.1.M.B.pfm
Alignment	ELF2.H12CORE.1.M.B.words.tsv
Threshold to P-value map	ELF2.H12CORE.1.M.B.thr
Motif in other formats
JASPAR format	ELF2.H12CORE.1.M.B_jaspar_format.txt
MEME format	ELF2.H12CORE.1.M.B_meme_format.meme
Transfac format	ELF2.H12CORE.1.M.B_transfac_format.txt
Homer format	ELF2.H12CORE.1.M.B_homer_format_0.001.txt ELF2.H12CORE.1.M.B_homer_format_0.0005.txt ELF2.H12CORE.1.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3664.75	1317.75	2420.75	1993.75
02	4907.0	640.0	1208.0	2642.0
03	3464.0	2051.0	1571.0	2311.0
04	763.0	6852.0	1451.0	331.0
05	5423.0	3946.0	24.0	4.0
06	0.0	1.0	9396.0	0.0
07	0.0	0.0	9397.0	0.0
08	9397.0	0.0	0.0	0.0
09	9395.0	1.0	0.0	1.0
10	134.0	5.0	9258.0	0.0
11	159.0	923.0	269.0	8046.0
12	4430.0	736.0	3386.0	845.0
13	2946.5	2621.5	2204.5	1624.5

PFM

	A	C	G	T
01	0.39	0.14	0.258	0.212
02	0.522	0.068	0.129	0.281
03	0.369	0.218	0.167	0.246
04	0.081	0.729	0.154	0.035
05	0.577	0.42	0.003	0.0
06	0.0	0.0	1.0	0.0
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	1.0	0.0	0.0	0.0
10	0.014	0.001	0.985	0.0
11	0.017	0.098	0.029	0.856
12	0.471	0.078	0.36	0.09
13	0.314	0.279	0.235	0.173

PWM

	A	C	G	T
01	0.444	-0.577	0.03	-0.164
02	0.736	-1.298	-0.664	0.117
03	0.388	-0.136	-0.402	-0.016
04	-1.123	1.07	-0.481	-1.954
05	0.836	0.518	-4.494	-5.924
06	-6.936	-6.573	1.385	-6.936
07	-6.936	-6.936	1.386	-6.936
08	1.386	-6.936	-6.936	-6.936
09	1.385	-6.573	-6.936	-6.573
10	-2.848	-5.777	1.371	-6.936
11	-2.68	-0.933	-2.16	1.23
12	0.634	-1.158	0.365	-1.021
13	0.226	0.11	-0.064	-0.368

Standard thresholds

P-value	Threshold
0.001	1.33331
0.0005	3.259965
0.0001	7.07211