MotifEGR3.H12INVIVO.0.PSM.A
Gene (human)EGR3
(GeneCards)
Gene synonyms (human)PILOT
Gene (mouse)Egr3
Gene synonyms (mouse)Egr-3
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length13
ConsensusnShGKGGGMGKvd
GC content69.63%
Information content (bits; total / per base)9.985 / 0.768
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words953

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 1 (5) 0.869 0.928 0.708 0.826 0.899 0.9 3.113 3.13 102.237 169.108

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.624 0.609 0.553 0.557 0.526 0.533
best 0.947 0.894 0.948 0.901 0.934 0.89
Methyl HT-SELEX, 1 experiments median 0.907 0.855 0.774 0.755 0.621 0.648
best 0.907 0.855 0.774 0.755 0.621 0.648
Non-Methyl HT-SELEX, 5 experiments median 0.601 0.584 0.543 0.544 0.522 0.525
best 0.947 0.894 0.948 0.901 0.934 0.89

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.656 0.27 0.671 0.438
batch 2 0.669 0.364 0.725 0.435
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classC2H2 zinc finger factors {2.3} (TFClass)
TF familyThree-zinc finger Kruppel-related {2.3.1} (TFClass)
TF subfamilyEGR {2.3.1.3} (TFClass)
TFClass IDTFClass: 2.3.1.3.3
HGNCHGNC:3240
MGIMGI:1306780
EntrezGene (human)GeneID:1960
(SSTAR profile)
EntrezGene (mouse)GeneID:13655
(SSTAR profile)
UniProt ID (human)EGR3_HUMAN
UniProt ID (mouse)EGR3_MOUSE
UniProt AC (human)Q06889
(TFClass)
UniProt AC (mouse)P43300
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 1 human, 0 mouse
HT-SELEX 5
Methyl-HT-SELEX 1
PCM
ACGT
01156.0182.0360.0255.0
02100.0181.0602.070.0
03282.0236.0100.0335.0
0423.028.0891.011.0
0559.045.0419.0430.0
06224.010.0712.07.0
071.02.0928.022.0
088.010.0928.07.0
09372.0312.01.0268.0
1096.09.0786.062.0
1158.062.0675.0158.0
12273.0195.0351.0134.0
13178.0120.0482.0173.0
PFM
ACGT
010.1640.1910.3780.268
020.1050.190.6320.073
030.2960.2480.1050.352
040.0240.0290.9350.012
050.0620.0470.440.451
060.2350.010.7470.007
070.0010.0020.9740.023
080.0080.010.9740.007
090.390.3270.0010.281
100.1010.0090.8250.065
110.0610.0650.7080.166
120.2860.2050.3680.141
130.1870.1260.5060.182
PWM
ACGT
01-0.42-0.2670.410.067
02-0.858-0.2730.923-1.208
030.167-0.009-0.8580.339
04-2.273-2.0891.314-2.938
05-1.374-1.6360.5610.587
06-0.061-3.021.09-3.315
07-4.482-4.1681.354-2.314
08-3.207-3.021.354-3.315
090.4430.268-4.4820.117
10-0.898-3.1091.189-1.326
11-1.391-1.3261.037-0.407
120.135-0.1990.385-0.57
13-0.289-0.6790.701-0.317
Standard thresholds
P-value Threshold
0.001 4.77761
0.0005 5.65061
0.0001 7.36976