E2F8.H12RSNP.1.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F8.H12RSNP.1.SM.D
Gene (human)	E2F8 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f8
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	13
Consensus	dKKRCGGGAAWhn
GC content	51.52%
Information content (bits; total / per base)	14.37 / 1.105
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9422

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.809	0.817	0.761	0.769	0.823	0.83	3.318	3.38	49.585	60.097

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.998	0.998	0.991	0.989	0.933	0.935
Overall, 2 experiments	best	0.999	0.999	0.998	0.997	0.994	0.992
Methyl HT-SELEX, 1 experiments	median	0.998	0.997	0.985	0.981	0.871	0.878
Methyl HT-SELEX, 1 experiments	best	0.998	0.997	0.985	0.981	0.871	0.878
Non-Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.998	0.997	0.994	0.992
Non-Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.998	0.997	0.994	0.992

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.8
HGNC	HGNC:24727
MGI	MGI:1922038
EntrezGene (human)	GeneID:79733 (SSTAR profile)
EntrezGene (mouse)	GeneID:108961 (SSTAR profile)
UniProt ID (human)	E2F8_HUMAN
UniProt ID (mouse)	E2F8_MOUSE
UniProt AC (human)	A0AVK6 (TFClass)
UniProt AC (mouse)	Q58FA4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	E2F8.H12RSNP.1.SM.D.pcm
PWM	E2F8.H12RSNP.1.SM.D.pwm
PFM	E2F8.H12RSNP.1.SM.D.pfm
Alignment	E2F8.H12RSNP.1.SM.D.words.tsv
Threshold to P-value map	E2F8.H12RSNP.1.SM.D.thr
Motif in other formats
JASPAR format	E2F8.H12RSNP.1.SM.D_jaspar_format.txt
MEME format	E2F8.H12RSNP.1.SM.D_meme_format.meme
Transfac format	E2F8.H12RSNP.1.SM.D_transfac_format.txt
Homer format	E2F8.H12RSNP.1.SM.D_homer_format_0.001.txt E2F8.H12RSNP.1.SM.D_homer_format_0.0005.txt E2F8.H12RSNP.1.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3503.0	998.0	1141.0	3780.0
02	1496.5	642.5	1655.5	5627.5
03	846.0	628.0	5285.0	2663.0
04	2594.0	119.0	6529.0	180.0
05	8.0	9409.0	0.0	5.0
06	0.0	0.0	9422.0	0.0
07	1.0	24.0	9397.0	0.0
08	3.0	2.0	9416.0	1.0
09	9325.0	0.0	90.0	7.0
10	8710.0	41.0	557.0	114.0
11	6791.0	601.0	500.0	1530.0
12	3243.5	1464.5	1227.5	3486.5
13	2164.25	1943.25	2009.25	3305.25

PFM

	A	C	G	T
01	0.372	0.106	0.121	0.401
02	0.159	0.068	0.176	0.597
03	0.09	0.067	0.561	0.283
04	0.275	0.013	0.693	0.019
05	0.001	0.999	0.0	0.001
06	0.0	0.0	1.0	0.0
07	0.0	0.003	0.997	0.0
08	0.0	0.0	0.999	0.0
09	0.99	0.0	0.01	0.001
10	0.924	0.004	0.059	0.012
11	0.721	0.064	0.053	0.162
12	0.344	0.155	0.13	0.37
13	0.23	0.206	0.213	0.351

PWM

	A	C	G	T
01	0.397	-0.857	-0.724	0.473
02	-0.453	-1.297	-0.352	0.87
03	-1.022	-1.319	0.808	0.123
04	0.096	-2.967	1.019	-2.56
05	-5.435	1.384	-6.938	-5.779
06	-6.938	-6.938	1.386	-6.938
07	-6.575	-4.496	1.383	-6.938
08	-6.1	-6.31	1.385	-6.575
09	1.375	-6.938	-3.241	-5.537
10	1.307	-3.998	-1.439	-3.009
11	1.058	-1.363	-1.546	-0.431
12	0.32	-0.475	-0.651	0.392
13	-0.085	-0.192	-0.159	0.338

Standard thresholds

P-value	Threshold
0.001	1.57036
0.0005	3.224415
0.0001	6.731965