E2F8.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F8.H12INVITRO.1.SM.B
Gene (human)	E2F8 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f8
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	17
Consensus	nddWTGGCGGGAAWdnn
GC content	48.09%
Information content (bits; total / per base)	18.084 / 1.064
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1714

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.799	0.801	0.751	0.756	0.817	0.825	3.409	3.41	48.229	58.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.999	0.998	0.99	0.988	0.933	0.934
Overall, 2 experiments	best	1.0	0.999	0.999	0.998	0.995	0.993
Methyl HT-SELEX, 1 experiments	median	0.998	0.997	0.982	0.977	0.872	0.876
Methyl HT-SELEX, 1 experiments	best	0.998	0.997	0.982	0.977	0.872	0.876
Non-Methyl HT-SELEX, 1 experiments	median	1.0	0.999	0.999	0.998	0.995	0.993
Non-Methyl HT-SELEX, 1 experiments	best	1.0	0.999	0.999	0.998	0.995	0.993

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.8
HGNC	HGNC:24727
MGI	MGI:1922038
EntrezGene (human)	GeneID:79733 (SSTAR profile)
EntrezGene (mouse)	GeneID:108961 (SSTAR profile)
UniProt ID (human)	E2F8_HUMAN
UniProt ID (mouse)	E2F8_MOUSE
UniProt AC (human)	A0AVK6 (TFClass)
UniProt AC (mouse)	Q58FA4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	E2F8.H12INVITRO.1.SM.B.pcm
PWM	E2F8.H12INVITRO.1.SM.B.pwm
PFM	E2F8.H12INVITRO.1.SM.B.pfm
Alignment	E2F8.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	E2F8.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	E2F8.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	E2F8.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	E2F8.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	E2F8.H12INVITRO.1.SM.B_homer_format_0.001.txt E2F8.H12INVITRO.1.SM.B_homer_format_0.0005.txt E2F8.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	609.75	337.75	459.75	306.75
02	831.75	127.75	251.75	502.75
03	629.0	113.0	173.0	799.0
04	522.0	104.0	150.0	938.0
05	49.0	27.0	49.0	1589.0
06	82.0	17.0	1478.0	137.0
07	81.0	0.0	1633.0	0.0
08	0.0	1714.0	0.0	0.0
09	0.0	0.0	1714.0	0.0
10	0.0	1.0	1713.0	0.0
11	0.0	0.0	1714.0	0.0
12	1714.0	0.0	0.0	0.0
13	1610.0	5.0	79.0	20.0
14	1160.0	123.0	104.0	327.0
15	479.0	263.0	310.0	662.0
16	434.5	278.5	387.5	613.5
17	441.25	298.25	386.25	588.25

PFM

	A	C	G	T
01	0.356	0.197	0.268	0.179
02	0.485	0.075	0.147	0.293
03	0.367	0.066	0.101	0.466
04	0.305	0.061	0.088	0.547
05	0.029	0.016	0.029	0.927
06	0.048	0.01	0.862	0.08
07	0.047	0.0	0.953	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.0	1.0	0.0
10	0.0	0.001	0.999	0.0
11	0.0	0.0	1.0	0.0
12	1.0	0.0	0.0	0.0
13	0.939	0.003	0.046	0.012
14	0.677	0.072	0.061	0.191
15	0.279	0.153	0.181	0.386
16	0.254	0.162	0.226	0.358
17	0.257	0.174	0.225	0.343

PWM

	A	C	G	T
01	0.351	-0.237	0.07	-0.333
02	0.661	-1.2	-0.529	0.159
03	0.382	-1.321	-0.901	0.621
04	0.197	-1.402	-1.042	0.781
05	-2.136	-2.702	-2.136	1.307
06	-1.635	-3.127	1.235	-1.131
07	-1.647	-5.443	1.335	-5.443
08	-5.443	1.383	-5.443	-5.443
09	-5.443	-5.443	1.383	-5.443
10	-5.443	-5.013	1.382	-5.443
11	-5.443	-5.443	1.383	-5.443
12	1.383	-5.443	-5.443	-5.443
13	1.321	-4.139	-1.672	-2.98
14	0.993	-1.237	-1.402	-0.269
15	0.111	-0.485	-0.322	0.433
16	0.014	-0.429	-0.1	0.358
17	0.029	-0.36	-0.103	0.316

Standard thresholds

P-value	Threshold
0.001	-0.49309
0.0005	1.20486
0.0001	4.75161