E2F8.H12CORE.0.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F8.H12CORE.0.P.C
Gene (human)	E2F8 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f8
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	C

Motif length	11
Consensus	dSGCGGGAAMn
GC content	61.92%
Information content (bits; total / per base)	11.979 / 1.089
Data sources	ChIP-Seq
Aligned words	281

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (7)	0.83	0.834	0.788	0.789	0.854	0.859	3.822	3.924	61.42	61.553

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.998	0.997	0.981	0.977	0.922	0.921
Overall, 2 experiments	best	0.999	0.999	0.998	0.997	0.996	0.994
Methyl HT-SELEX, 1 experiments	median	0.996	0.995	0.963	0.956	0.848	0.848
Methyl HT-SELEX, 1 experiments	best	0.996	0.995	0.963	0.956	0.848	0.848
Non-Methyl HT-SELEX, 1 experiments	median	0.999	0.999	0.998	0.997	0.996	0.994
Non-Methyl HT-SELEX, 1 experiments	best	0.999	0.999	0.998	0.997	0.996	0.994

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.8
HGNC	HGNC:24727
MGI	MGI:1922038
EntrezGene (human)	GeneID:79733 (SSTAR profile)
EntrezGene (mouse)	GeneID:108961 (SSTAR profile)
UniProt ID (human)	E2F8_HUMAN
UniProt ID (mouse)	E2F8_MOUSE
UniProt AC (human)	A0AVK6 (TFClass)
UniProt AC (mouse)	Q58FA4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	E2F8.H12CORE.0.P.C.pcm
PWM	E2F8.H12CORE.0.P.C.pwm
PFM	E2F8.H12CORE.0.P.C.pfm
Alignment	E2F8.H12CORE.0.P.C.words.tsv
Threshold to P-value map	E2F8.H12CORE.0.P.C.thr
Motif in other formats
JASPAR format	E2F8.H12CORE.0.P.C_jaspar_format.txt
MEME format	E2F8.H12CORE.0.P.C_meme_format.meme
Transfac format	E2F8.H12CORE.0.P.C_transfac_format.txt
Homer format	E2F8.H12CORE.0.P.C_homer_format_0.001.txt E2F8.H12CORE.0.P.C_homer_format_0.0005.txt E2F8.H12CORE.0.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	45.0	26.0	58.0	152.0
02	9.0	73.0	195.0	4.0
03	2.0	8.0	264.0	7.0
04	17.0	251.0	3.0	10.0
05	2.0	3.0	252.0	24.0
06	3.0	17.0	259.0	2.0
07	12.0	16.0	251.0	2.0
08	274.0	1.0	3.0	3.0
09	227.0	7.0	42.0	5.0
10	187.0	36.0	32.0	26.0
11	99.0	64.0	53.0	65.0

PFM

	A	C	G	T
01	0.16	0.093	0.206	0.541
02	0.032	0.26	0.694	0.014
03	0.007	0.028	0.94	0.025
04	0.06	0.893	0.011	0.036
05	0.007	0.011	0.897	0.085
06	0.011	0.06	0.922	0.007
07	0.043	0.057	0.893	0.007
08	0.975	0.004	0.011	0.011
09	0.808	0.025	0.149	0.018
10	0.665	0.128	0.114	0.093
11	0.352	0.228	0.189	0.231

PWM

	A	C	G	T
01	-0.434	-0.961	-0.187	0.761
02	-1.929	0.038	1.008	-2.584
03	-3.045	-2.03	1.309	-2.143
04	-1.359	1.259	-2.788	-1.837
05	-3.045	-2.788	1.263	-1.037
06	-2.788	-1.359	1.29	-3.045
07	-1.676	-1.415	1.259	-3.045
08	1.346	-3.392	-2.788	-2.788
09	1.159	-2.143	-0.501	-2.414
10	0.967	-0.65	-0.763	-0.961
11	0.337	-0.091	-0.275	-0.076

Standard thresholds

P-value	Threshold
0.001	4.30837
0.0005	5.259115
0.0001	7.19405