E2F4.H12INVITRO.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F4.H12INVITRO.2.S.B
Gene (human)	E2F4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	16
Consensus	nndWdTGGCGCShhhn
GC content	57.33%
Information content (bits; total / per base)	14.174 / 0.886
Data sources	HT-SELEX
Aligned words	9628

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (56)	0.718	0.765	0.507	0.554	0.547	0.623	1.22	1.444	23.149	38.854
Mouse	12 (81)	0.757	0.8	0.573	0.642	0.55	0.612	1.299	1.505	19.276	58.137

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.756	0.758	0.752	0.751	0.742	0.74
Non-Methyl HT-SELEX, 2 experiments	best	0.999	0.998	0.996	0.994	0.979	0.975

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.57	0.105	0.352	0.215

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.4
HGNC	HGNC:3118
MGI	MGI:103012
EntrezGene (human)	GeneID:1874 (SSTAR profile)
EntrezGene (mouse)	GeneID:104394 (SSTAR profile)
UniProt ID (human)	E2F4_HUMAN
UniProt ID (mouse)	E2F4_MOUSE
UniProt AC (human)	Q16254 (TFClass)
UniProt AC (mouse)	Q8R0K9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 12 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	E2F4.H12INVITRO.2.S.B.pcm
PWM	E2F4.H12INVITRO.2.S.B.pwm
PFM	E2F4.H12INVITRO.2.S.B.pfm
Alignment	E2F4.H12INVITRO.2.S.B.words.tsv
Threshold to P-value map	E2F4.H12INVITRO.2.S.B.thr
Motif in other formats
JASPAR format	E2F4.H12INVITRO.2.S.B_jaspar_format.txt
MEME format	E2F4.H12INVITRO.2.S.B_meme_format.meme
Transfac format	E2F4.H12INVITRO.2.S.B_transfac_format.txt
Homer format	E2F4.H12INVITRO.2.S.B_homer_format_0.001.txt E2F4.H12INVITRO.2.S.B_homer_format_0.0005.txt E2F4.H12INVITRO.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2689.0	2271.0	2524.0	2144.0
02	2856.75	1735.75	2898.75	2136.75
03	3036.0	1088.0	1788.0	3716.0
04	3844.0	548.0	818.0	4418.0
05	3111.0	222.0	2225.0	4070.0
06	45.0	0.0	44.0	9539.0
07	6.0	1.0	9621.0	0.0
08	1.0	0.0	9627.0	0.0
09	2.0	9626.0	0.0	0.0
10	1.0	0.0	9627.0	0.0
11	3.0	9566.0	56.0	3.0
12	5.0	5320.0	3831.0	472.0
13	4226.0	3345.0	507.0	1550.0
14	1688.0	2092.0	1269.0	4579.0
15	2324.25	1747.25	1421.25	4135.25
16	2158.0	2120.0	2378.0	2972.0

PFM

	A	C	G	T
01	0.279	0.236	0.262	0.223
02	0.297	0.18	0.301	0.222
03	0.315	0.113	0.186	0.386
04	0.399	0.057	0.085	0.459
05	0.323	0.023	0.231	0.423
06	0.005	0.0	0.005	0.991
07	0.001	0.0	0.999	0.0
08	0.0	0.0	1.0	0.0
09	0.0	1.0	0.0	0.0
10	0.0	0.0	1.0	0.0
11	0.0	0.994	0.006	0.0
12	0.001	0.553	0.398	0.049
13	0.439	0.347	0.053	0.161
14	0.175	0.217	0.132	0.476
15	0.241	0.181	0.148	0.43
16	0.224	0.22	0.247	0.309

PWM

	A	C	G	T
01	0.111	-0.058	0.047	-0.116
02	0.171	-0.327	0.186	-0.119
03	0.232	-0.793	-0.297	0.434
04	0.468	-1.477	-1.077	0.607
05	0.256	-2.374	-0.079	0.525
06	-3.931	-6.957	-3.952	1.376
07	-5.672	-6.595	1.385	-6.957
08	-6.595	-6.957	1.385	-6.957
09	-6.33	1.385	-6.957	-6.957
10	-6.595	-6.957	1.385	-6.957
11	-6.121	1.379	-3.722	-6.121
12	-5.8	0.793	0.464	-1.625
13	0.562	0.329	-1.554	-0.44
14	-0.354	-0.14	-0.639	0.643
15	-0.035	-0.32	-0.526	0.541
16	-0.109	-0.127	-0.012	0.211

Standard thresholds

P-value	Threshold
0.001	0.96991
0.0005	2.37976
0.0001	6.63901