E2F4.H12INVITRO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F4.H12INVITRO.1.P.B
Gene (human)	E2F4 (GeneCards)
Gene synonyms (human)
Gene (mouse)	E2f4
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	13
Consensus	nndSGCGGGARvn
GC content	64.7%
Information content (bits; total / per base)	10.533 / 0.81
Data sources	ChIP-Seq
Aligned words	1001

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (56)	0.794	0.858	0.657	0.761	0.778	0.846	2.474	3.041	111.673	217.538
Mouse	12 (81)	0.811	0.91	0.676	0.796	0.745	0.915	2.239	3.816	73.367	217.328

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.712	0.681	0.708	0.679	0.691	0.666
Non-Methyl HT-SELEX, 2 experiments	best	0.915	0.85	0.915	0.854	0.885	0.83

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.603	0.085	0.368	0.195

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.4
HGNC	HGNC:3118
MGI	MGI:103012
EntrezGene (human)	GeneID:1874 (SSTAR profile)
EntrezGene (mouse)	GeneID:104394 (SSTAR profile)
UniProt ID (human)	E2F4_HUMAN
UniProt ID (mouse)	E2F4_MOUSE
UniProt AC (human)	Q16254 (TFClass)
UniProt AC (mouse)	Q8R0K9 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 12 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	E2F4.H12INVITRO.1.P.B.pcm
PWM	E2F4.H12INVITRO.1.P.B.pwm
PFM	E2F4.H12INVITRO.1.P.B.pfm
Alignment	E2F4.H12INVITRO.1.P.B.words.tsv
Threshold to P-value map	E2F4.H12INVITRO.1.P.B.thr
Motif in other formats
JASPAR format	E2F4.H12INVITRO.1.P.B_jaspar_format.txt
MEME format	E2F4.H12INVITRO.1.P.B_meme_format.meme
Transfac format	E2F4.H12INVITRO.1.P.B_transfac_format.txt
Homer format	E2F4.H12INVITRO.1.P.B_homer_format_0.001.txt E2F4.H12INVITRO.1.P.B_homer_format_0.0005.txt E2F4.H12INVITRO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	203.0	244.0	372.0	182.0
02	320.0	152.0	269.0	260.0
03	208.0	78.0	373.0	342.0
04	88.0	205.0	700.0	8.0
05	9.0	35.0	952.0	5.0
06	50.0	920.0	3.0	28.0
07	12.0	10.0	953.0	26.0
08	5.0	230.0	760.0	6.0
09	19.0	108.0	855.0	19.0
10	860.0	88.0	37.0	16.0
11	716.0	48.0	209.0	28.0
12	455.0	157.0	238.0	151.0
13	304.0	169.0	254.0	274.0

PFM

	A	C	G	T
01	0.203	0.244	0.372	0.182
02	0.32	0.152	0.269	0.26
03	0.208	0.078	0.373	0.342
04	0.088	0.205	0.699	0.008
05	0.009	0.035	0.951	0.005
06	0.05	0.919	0.003	0.028
07	0.012	0.01	0.952	0.026
08	0.005	0.23	0.759	0.006
09	0.019	0.108	0.854	0.019
10	0.859	0.088	0.037	0.016
11	0.715	0.048	0.209	0.028
12	0.455	0.157	0.238	0.151
13	0.304	0.169	0.254	0.274

PWM

	A	C	G	T
01	-0.208	-0.025	0.394	-0.316
02	0.244	-0.494	0.072	0.038
03	-0.184	-1.151	0.397	0.311
04	-1.033	-0.198	1.024	-3.254
05	-3.157	-1.926	1.331	-3.623
06	-1.583	1.297	-3.976	-2.137
07	-2.91	-3.067	1.332	-2.207
08	-3.623	-0.084	1.106	-3.485
09	-2.498	-0.831	1.224	-2.498
10	1.23	-1.033	-1.873	-2.654
11	1.047	-1.623	-0.179	-2.137
12	0.595	-0.462	-0.05	-0.501
13	0.193	-0.389	0.015	0.09

Standard thresholds

P-value	Threshold
0.001	4.60151
0.0005	5.49141
0.0001	7.31546