E2F3.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F3.H12INVIVO.1.SM.B
Gene (human)	E2F3 (GeneCards)
Gene synonyms (human)	KIAA0075
Gene (mouse)	E2f3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	15
Consensus	hWKGGCGCCAAAAhn
GC content	49.54%
Information content (bits; total / per base)	17.081 / 1.139
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	276

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	7 (37)	0.572	0.8	0.456	0.618	0.393	0.516	0.856	1.225	15.721	59.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.791	0.796	0.659	0.672	0.582	0.603
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	0.997	0.996
Methyl HT-SELEX, 1 experiments	median	0.914	0.907	0.744	0.751	0.631	0.653
Methyl HT-SELEX, 1 experiments	best	0.914	0.907	0.744	0.751	0.631	0.653
Non-Methyl HT-SELEX, 3 experiments	median	0.667	0.685	0.573	0.593	0.534	0.552
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.997	0.996

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.3
HGNC	HGNC:3115
MGI	MGI:1096340
EntrezGene (human)	GeneID:1871 (SSTAR profile)
EntrezGene (mouse)	GeneID:13557 (SSTAR profile)
UniProt ID (human)	E2F3_HUMAN
UniProt ID (mouse)	E2F3_MOUSE
UniProt AC (human)	O00716 (TFClass)
UniProt AC (mouse)	O35261 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 7 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	E2F3.H12INVIVO.1.SM.B.pcm
PWM	E2F3.H12INVIVO.1.SM.B.pwm
PFM	E2F3.H12INVIVO.1.SM.B.pfm
Alignment	E2F3.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	E2F3.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	E2F3.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	E2F3.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	E2F3.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	E2F3.H12INVIVO.1.SM.B_homer_format_0.001.txt E2F3.H12INVIVO.1.SM.B_homer_format_0.0005.txt E2F3.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	132.5	24.5	18.5	100.5
02	139.0	4.0	14.0	119.0
03	54.0	0.0	71.0	151.0
04	0.0	80.0	196.0	0.0
05	0.0	0.0	276.0	0.0
06	0.0	276.0	0.0	0.0
07	0.0	0.0	276.0	0.0
08	0.0	276.0	0.0	0.0
09	0.0	240.0	36.0	0.0
10	238.0	25.0	1.0	12.0
11	220.0	0.0	3.0	53.0
12	232.0	5.0	11.0	28.0
13	224.0	6.0	7.0	39.0
14	97.25	57.25	31.25	90.25
15	77.75	58.75	57.75	81.75

PFM

	A	C	G	T
01	0.48	0.089	0.067	0.364
02	0.504	0.014	0.051	0.431
03	0.196	0.0	0.257	0.547
04	0.0	0.29	0.71	0.0
05	0.0	0.0	1.0	0.0
06	0.0	1.0	0.0	0.0
07	0.0	0.0	1.0	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.87	0.13	0.0
10	0.862	0.091	0.004	0.043
11	0.797	0.0	0.011	0.192
12	0.841	0.018	0.04	0.101
13	0.812	0.022	0.025	0.141
14	0.352	0.207	0.113	0.327
15	0.282	0.213	0.209	0.296

PWM

	A	C	G	T
01	0.643	-1.0	-1.263	0.37
02	0.69	-2.567	-1.52	0.537
03	-0.24	-3.914	0.028	0.772
04	-3.914	0.145	1.031	-3.914
05	-3.914	-3.914	1.371	-3.914
06	-3.914	1.371	-3.914	-3.914
07	-3.914	-3.914	1.371	-3.914
08	-3.914	1.371	-3.914	-3.914
09	-3.914	1.232	-0.632	-3.914
10	1.224	-0.981	-3.377	-1.659
11	1.146	-3.914	-2.772	-0.258
12	1.199	-2.397	-1.736	-0.873
13	1.164	-2.252	-2.125	-0.555
14	0.337	-0.183	-0.768	0.264
15	0.117	-0.157	-0.174	0.166

Standard thresholds

P-value	Threshold
0.001	1.81371
0.0005	3.17926
0.0001	6.02166