E2F3.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F3.H12INVITRO.1.SM.B
Gene (human)	E2F3 (GeneCards)
Gene synonyms (human)	KIAA0075
Gene (mouse)	E2f3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	nddWWWKSGCGCCAWW
GC content	47.6%
Information content (bits; total / per base)	15.947 / 0.997
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1421

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	7 (37)	0.596	0.783	0.458	0.601	0.368	0.512	0.829	1.158	10.921	39.229

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.805	0.81	0.672	0.684	0.591	0.611
Overall, 4 experiments	best	1.0	1.0	1.0	1.0	0.998	0.998
Methyl HT-SELEX, 1 experiments	median	0.927	0.922	0.761	0.767	0.642	0.664
Methyl HT-SELEX, 1 experiments	best	0.927	0.922	0.761	0.767	0.642	0.664
Non-Methyl HT-SELEX, 3 experiments	median	0.683	0.698	0.582	0.601	0.539	0.557
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	1.0	0.998	0.998

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.3
HGNC	HGNC:3115
MGI	MGI:1096340
EntrezGene (human)	GeneID:1871 (SSTAR profile)
EntrezGene (mouse)	GeneID:13557 (SSTAR profile)
UniProt ID (human)	E2F3_HUMAN
UniProt ID (mouse)	E2F3_MOUSE
UniProt AC (human)	O00716 (TFClass)
UniProt AC (mouse)	O35261 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 7 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	E2F3.H12INVITRO.1.SM.B.pcm
PWM	E2F3.H12INVITRO.1.SM.B.pwm
PFM	E2F3.H12INVITRO.1.SM.B.pfm
Alignment	E2F3.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	E2F3.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	E2F3.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	E2F3.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	E2F3.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	E2F3.H12INVITRO.1.SM.B_homer_format_0.001.txt E2F3.H12INVITRO.1.SM.B_homer_format_0.0005.txt E2F3.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	413.25	283.25	274.25	450.25
02	584.0	207.0	268.0	362.0
03	808.0	91.0	242.0	280.0
04	768.0	33.0	50.0	570.0
05	776.0	28.0	37.0	580.0
06	748.0	22.0	64.0	587.0
07	306.0	19.0	312.0	784.0
08	45.0	256.0	1032.0	88.0
09	0.0	0.0	1421.0	0.0
10	0.0	1421.0	0.0	0.0
11	0.0	0.0	1421.0	0.0
12	0.0	1421.0	0.0	0.0
13	4.0	1263.0	145.0	9.0
14	1178.0	107.0	18.0	118.0
15	1043.5	79.5	94.5	203.5
16	977.25	97.25	115.25	231.25

PFM

	A	C	G	T
01	0.291	0.199	0.193	0.317
02	0.411	0.146	0.189	0.255
03	0.569	0.064	0.17	0.197
04	0.54	0.023	0.035	0.401
05	0.546	0.02	0.026	0.408
06	0.526	0.015	0.045	0.413
07	0.215	0.013	0.22	0.552
08	0.032	0.18	0.726	0.062
09	0.0	0.0	1.0	0.0
10	0.0	1.0	0.0	0.0
11	0.0	0.0	1.0	0.0
12	0.0	1.0	0.0	0.0
13	0.003	0.889	0.102	0.006
14	0.829	0.075	0.013	0.083
15	0.734	0.056	0.067	0.143
16	0.688	0.068	0.081	0.163

PWM

	A	C	G	T
01	0.151	-0.225	-0.257	0.236
02	0.495	-0.536	-0.28	0.019
03	0.819	-1.347	-0.382	-0.237
04	0.768	-2.328	-1.93	0.471
05	0.779	-2.483	-2.219	0.488
06	0.742	-2.708	-1.691	0.5
07	-0.148	-2.842	-0.129	0.789
08	-2.032	-0.326	1.063	-1.38
09	-5.282	-5.282	1.382	-5.282
10	-5.282	1.382	-5.282	-5.282
11	-5.282	-5.282	1.382	-5.282
12	-5.282	1.382	-5.282	-5.282
13	-4.118	1.265	-0.889	-3.497
14	1.195	-1.188	-2.891	-1.092
15	1.074	-1.48	-1.31	-0.553
16	1.009	-1.282	-1.115	-0.427

Standard thresholds

P-value	Threshold
0.001	1.70146
0.0005	3.18136
0.0001	6.21606