E2F1.H12RSNP.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F1.H12RSNP.1.S.B
Gene (human)	E2F1 (GeneCards)
Gene synonyms (human)	RBBP3
Gene (mouse)	E2f1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	ndWWKGGCGCShdn
GC content	56.39%
Information content (bits; total / per base)	11.314 / 0.808
Data sources	HT-SELEX
Aligned words	9511

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	29 (176)	0.763	0.801	0.572	0.632	0.506	0.569	1.145	1.397	31.428	92.032
Mouse	2 (12)	0.788	0.816	0.618	0.667	0.488	0.506	1.072	1.164	18.469	64.602

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 3 experiments	median	0.852	0.847	0.648	0.685	0.56	0.601
Non-Methyl HT-SELEX, 3 experiments	best	0.856	0.858	0.707	0.709	0.62	0.631

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.633	2.935	0.091	0.072

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.1
HGNC	HGNC:3113
MGI	MGI:101941
EntrezGene (human)	GeneID:1869 (SSTAR profile)
EntrezGene (mouse)	GeneID:13555 (SSTAR profile)
UniProt ID (human)	E2F1_HUMAN
UniProt ID (mouse)	E2F1_MOUSE
UniProt AC (human)	Q01094 (TFClass)
UniProt AC (mouse)	Q61501 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	29 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	0

PCM	E2F1.H12RSNP.1.S.B.pcm
PWM	E2F1.H12RSNP.1.S.B.pwm
PFM	E2F1.H12RSNP.1.S.B.pfm
Alignment	E2F1.H12RSNP.1.S.B.words.tsv
Threshold to P-value map	E2F1.H12RSNP.1.S.B.thr
Motif in other formats
JASPAR format	E2F1.H12RSNP.1.S.B_jaspar_format.txt
MEME format	E2F1.H12RSNP.1.S.B_meme_format.meme
Transfac format	E2F1.H12RSNP.1.S.B_transfac_format.txt
Homer format	E2F1.H12RSNP.1.S.B_homer_format_0.001.txt E2F1.H12RSNP.1.S.B_homer_format_0.0005.txt E2F1.H12RSNP.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2864.0	1689.0	2364.0	2594.0
02	2986.75	1079.75	1519.75	3924.75
03	2575.0	633.0	1011.0	5292.0
04	2896.0	308.0	824.0	5483.0
05	1435.0	250.0	2027.0	5799.0
06	628.0	717.0	8113.0	53.0
07	1.0	46.0	9456.0	8.0
08	0.0	9505.0	6.0	0.0
09	1.0	0.0	9510.0	0.0
10	121.0	8369.0	896.0	125.0
11	299.0	5695.0	2023.0	1494.0
12	4291.75	2194.75	669.75	2354.75
13	5255.75	1182.75	1250.75	1821.75
14	3532.5	1921.5	1819.5	2237.5

PFM

	A	C	G	T
01	0.301	0.178	0.249	0.273
02	0.314	0.114	0.16	0.413
03	0.271	0.067	0.106	0.556
04	0.304	0.032	0.087	0.576
05	0.151	0.026	0.213	0.61
06	0.066	0.075	0.853	0.006
07	0.0	0.005	0.994	0.001
08	0.0	0.999	0.001	0.0
09	0.0	0.0	1.0	0.0
10	0.013	0.88	0.094	0.013
11	0.031	0.599	0.213	0.157
12	0.451	0.231	0.07	0.248
13	0.553	0.124	0.132	0.192
14	0.371	0.202	0.191	0.235

PWM

	A	C	G	T
01	0.186	-0.342	-0.006	0.087
02	0.228	-0.788	-0.447	0.501
03	0.08	-1.321	-0.854	0.8
04	0.197	-2.037	-1.058	0.835
05	-0.504	-2.244	-0.159	0.891
06	-1.329	-1.197	1.227	-3.762
07	-6.584	-3.898	1.38	-5.444
08	-6.946	1.385	-5.66	-6.946
09	-6.584	-6.946	1.385	-6.946
10	-2.96	1.258	-0.974	-2.928
11	-2.067	0.873	-0.161	-0.464
12	0.59	-0.08	-1.265	-0.01
13	0.793	-0.697	-0.642	-0.266
14	0.396	-0.213	-0.267	-0.061

Standard thresholds

P-value	Threshold
0.001	4.39246
0.0005	5.46631
0.0001	7.44486