E2F1.H12INVIVO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F1.H12INVIVO.1.S.B
Gene (human)	E2F1 (GeneCards)
Gene synonyms (human)	RBBP3
Gene (mouse)	E2f1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	16
Consensus	ndddKGGCGCShdddn
GC content	63.08%
Information content (bits; total / per base)	11.339 / 0.709
Data sources	HT-SELEX
Aligned words	2109

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	29 (176)	0.768	0.814	0.566	0.627	0.625	0.687	1.464	1.697	50.452	97.081
Mouse	2 (12)	0.788	0.826	0.626	0.658	0.543	0.606	1.255	1.407	41.153	79.721

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 3 experiments	median	0.801	0.81	0.619	0.655	0.546	0.584
Non-Methyl HT-SELEX, 3 experiments	best	0.862	0.825	0.728	0.712	0.635	0.637

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.877	1.564	0.089	0.05

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.1
HGNC	HGNC:3113
MGI	MGI:101941
EntrezGene (human)	GeneID:1869 (SSTAR profile)
EntrezGene (mouse)	GeneID:13555 (SSTAR profile)
UniProt ID (human)	E2F1_HUMAN
UniProt ID (mouse)	E2F1_MOUSE
UniProt AC (human)	Q01094 (TFClass)
UniProt AC (mouse)	Q61501 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	29 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	0

PCM	E2F1.H12INVIVO.1.S.B.pcm
PWM	E2F1.H12INVIVO.1.S.B.pwm
PFM	E2F1.H12INVIVO.1.S.B.pfm
Alignment	E2F1.H12INVIVO.1.S.B.words.tsv
Threshold to P-value map	E2F1.H12INVIVO.1.S.B.thr
Motif in other formats
JASPAR format	E2F1.H12INVIVO.1.S.B_jaspar_format.txt
MEME format	E2F1.H12INVIVO.1.S.B_meme_format.meme
Transfac format	E2F1.H12INVIVO.1.S.B_transfac_format.txt
Homer format	E2F1.H12INVIVO.1.S.B_homer_format_0.001.txt E2F1.H12INVIVO.1.S.B_homer_format_0.0005.txt E2F1.H12INVIVO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	510.0	398.0	786.0	415.0
02	483.25	240.25	679.25	706.25
03	458.0	172.0	733.0	746.0
04	600.0	58.0	452.0	999.0
05	305.0	3.0	691.0	1110.0
06	31.0	404.0	1660.0	14.0
07	4.0	0.0	2102.0	3.0
08	44.0	2041.0	0.0	24.0
09	0.0	0.0	2108.0	1.0
10	7.0	2026.0	74.0	2.0
11	25.0	561.0	1450.0	73.0
12	536.0	824.0	199.0	550.0
13	601.0	131.0	753.0	624.0
14	546.0	231.0	577.0	755.0
15	463.75	203.75	664.75	776.75
16	386.25	387.25	676.25	659.25

PFM

	A	C	G	T
01	0.242	0.189	0.373	0.197
02	0.229	0.114	0.322	0.335
03	0.217	0.082	0.348	0.354
04	0.284	0.028	0.214	0.474
05	0.145	0.001	0.328	0.526
06	0.015	0.192	0.787	0.007
07	0.002	0.0	0.997	0.001
08	0.021	0.968	0.0	0.011
09	0.0	0.0	1.0	0.0
10	0.003	0.961	0.035	0.001
11	0.012	0.266	0.688	0.035
12	0.254	0.391	0.094	0.261
13	0.285	0.062	0.357	0.296
14	0.259	0.11	0.274	0.358
15	0.22	0.097	0.315	0.368
16	0.183	0.184	0.321	0.313

PWM

	A	C	G	T
01	-0.033	-0.28	0.398	-0.238
02	-0.087	-0.782	0.253	0.291
03	-0.14	-1.113	0.328	0.346
04	0.129	-2.178	-0.153	0.637
05	-0.545	-4.679	0.27	0.743
06	-2.777	-0.265	1.144	-3.504
07	-4.494	-5.622	1.38	-4.679
08	-2.445	1.351	-5.622	-3.017
09	-5.622	-5.622	1.383	-5.202
10	-4.084	1.343	-1.942	-4.907
11	-2.979	0.062	1.009	-1.955
12	0.016	0.445	-0.968	0.042
13	0.13	-1.382	0.355	0.168
14	0.035	-0.821	0.09	0.358
15	-0.128	-0.945	0.231	0.386
16	-0.31	-0.307	0.248	0.223

Standard thresholds

P-value	Threshold
0.001	4.18256
0.0005	5.35966
0.0001	7.62266