E2F1.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F1.H12INVITRO.1.S.B
Gene (human)	E2F1 (GeneCards)
Gene synonyms (human)	RBBP3
Gene (mouse)	E2f1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	nddWKGGCGCShdn
GC content	56.48%
Information content (bits; total / per base)	11.156 / 0.797
Data sources	HT-SELEX
Aligned words	9639

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	29 (176)	0.763	0.801	0.573	0.632	0.504	0.566	1.141	1.39	31.056	92.357
Mouse	2 (12)	0.788	0.816	0.618	0.666	0.486	0.504	1.068	1.159	19.13	63.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 3 experiments	median	0.854	0.847	0.653	0.687	0.565	0.604
Non-Methyl HT-SELEX, 3 experiments	best	0.857	0.859	0.707	0.709	0.618	0.63

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.475	2.675	0.093	0.071

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.1
HGNC	HGNC:3113
MGI	MGI:101941
EntrezGene (human)	GeneID:1869 (SSTAR profile)
EntrezGene (mouse)	GeneID:13555 (SSTAR profile)
UniProt ID (human)	E2F1_HUMAN
UniProt ID (mouse)	E2F1_MOUSE
UniProt AC (human)	Q01094 (TFClass)
UniProt AC (mouse)	Q61501 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	29 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	0

PCM	E2F1.H12INVITRO.1.S.B.pcm
PWM	E2F1.H12INVITRO.1.S.B.pwm
PFM	E2F1.H12INVITRO.1.S.B.pfm
Alignment	E2F1.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	E2F1.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	E2F1.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	E2F1.H12INVITRO.1.S.B_meme_format.meme
Transfac format	E2F1.H12INVITRO.1.S.B_transfac_format.txt
Homer format	E2F1.H12INVITRO.1.S.B_homer_format_0.001.txt E2F1.H12INVITRO.1.S.B_homer_format_0.0005.txt E2F1.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2897.5	1729.5	2391.5	2620.5
02	3020.5	1116.5	1548.5	3953.5
03	2615.0	661.0	1040.0	5323.0
04	2938.0	336.0	848.0	5517.0
05	1472.0	265.0	2059.0	5843.0
06	659.0	760.0	8155.0	65.0
07	6.0	66.0	9556.0	11.0
08	0.0	9614.0	25.0	0.0
09	9.0	0.0	9628.0	2.0
10	136.0	8470.0	903.0	130.0
11	321.0	5736.0	2062.0	1520.0
12	4330.5	2235.5	692.5	2380.5
13	5287.75	1205.75	1298.75	1846.75
14	3560.75	1949.75	1861.75	2266.75

PFM

	A	C	G	T
01	0.301	0.179	0.248	0.272
02	0.313	0.116	0.161	0.41
03	0.271	0.069	0.108	0.552
04	0.305	0.035	0.088	0.572
05	0.153	0.027	0.214	0.606
06	0.068	0.079	0.846	0.007
07	0.001	0.007	0.991	0.001
08	0.0	0.997	0.003	0.0
09	0.001	0.0	0.999	0.0
10	0.014	0.879	0.094	0.013
11	0.033	0.595	0.214	0.158
12	0.449	0.232	0.072	0.247
13	0.549	0.125	0.135	0.192
14	0.369	0.202	0.193	0.235

PWM

	A	C	G	T
01	0.184	-0.331	-0.008	0.084
02	0.226	-0.768	-0.442	0.495
03	0.082	-1.291	-0.839	0.792
04	0.198	-1.964	-1.043	0.828
05	-0.492	-2.2	-0.157	0.885
06	-1.294	-1.152	1.218	-3.579
07	-5.673	-3.564	1.377	-5.201
08	-6.958	1.383	-4.482	-6.958
09	-5.364	-6.958	1.384	-6.331
10	-2.859	1.256	-0.98	-2.903
11	-2.01	0.867	-0.156	-0.46
12	0.586	-0.075	-1.245	-0.012
13	0.785	-0.691	-0.617	-0.266
14	0.39	-0.212	-0.258	-0.061

Standard thresholds

P-value	Threshold
0.001	4.44876
0.0005	5.49756
0.0001	7.44226