E2F1.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	E2F1.H12INVITRO.0.P.B
Gene (human)	E2F1 (GeneCards)
Gene synonyms (human)	RBBP3
Gene (mouse)	E2f1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	ndSGCGGGARvnn
GC content	64.9%
Information content (bits; total / per base)	11.577 / 0.891
Data sources	ChIP-Seq
Aligned words	978

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	29 (176)	0.822	0.876	0.688	0.762	0.806	0.871	2.636	3.045	106.831	275.699
Mouse	2 (12)	0.783	0.823	0.658	0.692	0.681	0.745	2.102	2.29	38.979	81.252

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 3 experiments	median	0.659	0.595	0.616	0.576	0.546	0.555
Non-Methyl HT-SELEX, 3 experiments	best	0.748	0.691	0.62	0.61	0.575	0.561

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.489	2.678	0.099	0.058

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Fork head/winged helix factors {3.3} (TFClass)
TF family	E2F {3.3.2} (TFClass)
TF subfamily	E2F {3.3.2.1} (TFClass)
TFClass ID	TFClass: 3.3.2.1.1
HGNC	HGNC:3113
MGI	MGI:101941
EntrezGene (human)	GeneID:1869 (SSTAR profile)
EntrezGene (mouse)	GeneID:13555 (SSTAR profile)
UniProt ID (human)	E2F1_HUMAN
UniProt ID (mouse)	E2F1_MOUSE
UniProt AC (human)	Q01094 (TFClass)
UniProt AC (mouse)	Q61501 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	29 human, 2 mouse
HT-SELEX	3
Methyl-HT-SELEX	0

PCM	E2F1.H12INVITRO.0.P.B.pcm
PWM	E2F1.H12INVITRO.0.P.B.pwm
PFM	E2F1.H12INVITRO.0.P.B.pfm
Alignment	E2F1.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	E2F1.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	E2F1.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	E2F1.H12INVITRO.0.P.B_meme_format.meme
Transfac format	E2F1.H12INVITRO.0.P.B_transfac_format.txt
Homer format	E2F1.H12INVITRO.0.P.B_homer_format_0.001.txt E2F1.H12INVITRO.0.P.B_homer_format_0.0005.txt E2F1.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	288.0	204.0	241.0	245.0
02	192.0	96.0	442.0	248.0
03	87.0	193.0	693.0	5.0
04	17.0	8.0	950.0	3.0
05	24.0	949.0	1.0	4.0
06	10.0	9.0	931.0	28.0
07	14.0	129.0	832.0	3.0
08	41.0	73.0	855.0	9.0
09	902.0	19.0	45.0	12.0
10	722.0	40.0	201.0	15.0
11	489.0	175.0	206.0	108.0
12	360.0	209.0	214.0	195.0
13	224.0	224.0	312.0	218.0

PFM

	A	C	G	T
01	0.294	0.209	0.246	0.251
02	0.196	0.098	0.452	0.254
03	0.089	0.197	0.709	0.005
04	0.017	0.008	0.971	0.003
05	0.025	0.97	0.001	0.004
06	0.01	0.009	0.952	0.029
07	0.014	0.132	0.851	0.003
08	0.042	0.075	0.874	0.009
09	0.922	0.019	0.046	0.012
10	0.738	0.041	0.206	0.015
11	0.5	0.179	0.211	0.11
12	0.368	0.214	0.219	0.199
13	0.229	0.229	0.319	0.223

PWM

	A	C	G	T
01	0.163	-0.18	-0.014	0.002
02	-0.24	-0.924	0.589	0.014
03	-1.021	-0.235	1.037	-3.601
04	-2.577	-3.232	1.352	-3.954
05	-2.259	1.351	-4.505	-3.762
06	-3.045	-3.134	1.332	-2.114
07	-2.751	-0.633	1.22	-3.954
08	-1.752	-1.192	1.247	-3.134
09	1.3	-2.475	-1.662	-2.887
10	1.078	-1.775	-0.194	-2.69
11	0.69	-0.332	-0.17	-0.808
12	0.385	-0.156	-0.132	-0.224
13	-0.087	-0.087	0.242	-0.114

Standard thresholds

P-value	Threshold
0.001	4.272265
0.0005	5.250775
0.0001	7.263465