DMBX1.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DMBX1.H12CORE.0.SM.B
Gene (human)	DMBX1 (GeneCards)
Gene synonyms (human)	MBX, OTX3, PAXB
Gene (mouse)	Dmbx1
Gene synonyms (mouse)	Cdmx, Mbx, Otx3, PaxB
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	9
Consensus	nbSATTAvn
GC content	40.65%
Information content (bits; total / per base)	7.59 / 0.843
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8418

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.907	0.857	0.864	0.812	0.787	0.749
Overall, 6 experiments	best	0.984	0.973	0.973	0.958	0.934	0.915
Methyl HT-SELEX, 2 experiments	median	0.95	0.923	0.92	0.889	0.858	0.832
Methyl HT-SELEX, 2 experiments	best	0.984	0.973	0.973	0.958	0.934	0.915
Non-Methyl HT-SELEX, 4 experiments	median	0.811	0.765	0.742	0.708	0.676	0.657
Non-Methyl HT-SELEX, 4 experiments	best	0.937	0.897	0.908	0.864	0.845	0.806

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.58	0.128	0.488	0.297

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	DMBX {3.1.3.4} (TFClass)
TFClass ID	TFClass: 3.1.3.4.1
HGNC	HGNC:19026
MGI	MGI:2153518
EntrezGene (human)	GeneID:127343 (SSTAR profile)
EntrezGene (mouse)	GeneID:140477 (SSTAR profile)
UniProt ID (human)	DMBX1_HUMAN
UniProt ID (mouse)	DMBX1_MOUSE
UniProt AC (human)	Q8NFW5 (TFClass)
UniProt AC (mouse)	Q91ZK4 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	DMBX1.H12CORE.0.SM.B.pcm
PWM	DMBX1.H12CORE.0.SM.B.pwm
PFM	DMBX1.H12CORE.0.SM.B.pfm
Alignment	DMBX1.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	DMBX1.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	DMBX1.H12CORE.0.SM.B_jaspar_format.txt
MEME format	DMBX1.H12CORE.0.SM.B_meme_format.meme
Transfac format	DMBX1.H12CORE.0.SM.B_transfac_format.txt
Homer format	DMBX1.H12CORE.0.SM.B_homer_format_0.001.txt DMBX1.H12CORE.0.SM.B_homer_format_0.0005.txt DMBX1.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1943.25	2495.25	2418.25	1561.25
02	1216.75	1970.75	3784.75	1445.75
03	328.0	1461.0	6474.0	155.0
04	6721.0	1428.0	268.0	1.0
05	0.0	1.0	0.0	8417.0
06	10.0	463.0	0.0	7945.0
07	7633.0	511.0	60.0	214.0
08	3188.5	1677.5	2503.5	1048.5
09	1341.25	2872.25	2407.25	1797.25

PFM

	A	C	G	T
01	0.231	0.296	0.287	0.185
02	0.145	0.234	0.45	0.172
03	0.039	0.174	0.769	0.018
04	0.798	0.17	0.032	0.0
05	0.0	0.0	0.0	1.0
06	0.001	0.055	0.0	0.944
07	0.907	0.061	0.007	0.025
08	0.379	0.199	0.297	0.125
09	0.159	0.341	0.286	0.214

PWM

	A	C	G	T
01	-0.08	0.17	0.139	-0.298
02	-0.547	-0.066	0.586	-0.375
03	-1.853	-0.364	1.123	-2.595
04	1.16	-0.387	-2.054	-6.471
05	-6.838	-6.471	-6.838	1.385
06	-5.147	-1.51	-6.838	1.328
07	1.288	-1.412	-3.522	-2.276
08	0.415	-0.227	0.173	-0.696
09	-0.45	0.311	0.134	-0.158

Standard thresholds

P-value	Threshold
0.001	5.41093
0.0005	6.05508
0.0001	6.94548