DLX6.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX6.H12RSNP.0.SM.B
Gene (human)	DLX6 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx6
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	11
Consensus	nvnTAATTRbn
GC content	32.16%
Information content (bits; total / per base)	11.373 / 1.034
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9810

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.963	0.94	0.903	0.883	0.806	0.804
Overall, 4 experiments	best	0.979	0.963	0.973	0.954	0.952	0.93
Methyl HT-SELEX, 1 experiments	median	0.979	0.963	0.973	0.954	0.952	0.93
Methyl HT-SELEX, 1 experiments	best	0.979	0.963	0.973	0.954	0.952	0.93
Non-Methyl HT-SELEX, 3 experiments	median	0.95	0.922	0.84	0.822	0.682	0.702
Non-Methyl HT-SELEX, 3 experiments	best	0.976	0.958	0.967	0.945	0.93	0.907

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.6	0.149	0.493	0.287

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.6
HGNC	HGNC:2919
MGI	MGI:101927
EntrezGene (human)	GeneID:1750 (SSTAR profile)
EntrezGene (mouse)	GeneID:13396 (SSTAR profile)
UniProt ID (human)	DLX6_HUMAN
UniProt ID (mouse)	DLX6_MOUSE
UniProt AC (human)	P56179 (TFClass)
UniProt AC (mouse)	P70397 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	DLX6.H12RSNP.0.SM.B.pcm
PWM	DLX6.H12RSNP.0.SM.B.pwm
PFM	DLX6.H12RSNP.0.SM.B.pfm
Alignment	DLX6.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	DLX6.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	DLX6.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	DLX6.H12RSNP.0.SM.B_meme_format.meme
Transfac format	DLX6.H12RSNP.0.SM.B_transfac_format.txt
Homer format	DLX6.H12RSNP.0.SM.B_homer_format_0.001.txt DLX6.H12RSNP.0.SM.B_homer_format_0.0005.txt DLX6.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2454.5	3001.5	2495.5	1858.5
02	2132.0	2745.0	4148.0	785.0
03	2075.0	2772.0	2130.0	2833.0
04	0.0	74.0	14.0	9722.0
05	9810.0	0.0	0.0	0.0
06	9810.0	0.0	0.0	0.0
07	0.0	0.0	0.0	9810.0
08	0.0	8.0	9.0	9793.0
09	5449.0	0.0	4218.0	143.0
10	958.75	5142.75	2631.75	1076.75
11	2096.0	2658.0	2657.0	2399.0

PFM

	A	C	G	T
01	0.25	0.306	0.254	0.189
02	0.217	0.28	0.423	0.08
03	0.212	0.283	0.217	0.289
04	0.0	0.008	0.001	0.991
05	1.0	0.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.001	0.001	0.998
09	0.555	0.0	0.43	0.015
10	0.098	0.524	0.268	0.11
11	0.214	0.271	0.271	0.245

PWM

	A	C	G	T
01	0.001	0.202	0.017	-0.277
02	-0.14	0.113	0.525	-1.137
03	-0.167	0.122	-0.141	0.144
04	-6.974	-3.471	-5.015	1.377
05	1.386	-6.974	-6.974	-6.974
06	1.386	-6.974	-6.974	-6.974
07	-6.974	-6.974	-6.974	1.386
08	-6.974	-5.474	-5.381	1.384
09	0.798	-6.974	0.542	-2.827
10	-0.938	0.74	0.07	-0.822
11	-0.157	0.08	0.08	-0.022

Standard thresholds

P-value	Threshold
0.001	2.260625
0.0005	5.09912
0.0001	8.043545