DLX5.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX5.H12INVIVO.0.PSM.A
Gene (human)	DLX5 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	12
Consensus	bhTAATTRMWdn
GC content	32.64%
Information content (bits; total / per base)	10.094 / 0.841
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	999

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	3 (21)	0.858	0.894	0.774	0.85	0.825	0.851	2.765	3.176	129.959	240.337

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.967	0.944	0.957	0.929	0.933	0.902
Overall, 8 experiments	best	0.984	0.973	0.979	0.965	0.969	0.951
Methyl HT-SELEX, 3 experiments	median	0.976	0.957	0.969	0.947	0.948	0.923
Methyl HT-SELEX, 3 experiments	best	0.984	0.973	0.979	0.965	0.969	0.951
Non-Methyl HT-SELEX, 5 experiments	median	0.956	0.925	0.945	0.909	0.917	0.88
Non-Methyl HT-SELEX, 5 experiments	best	0.98	0.964	0.973	0.955	0.956	0.934

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.968	0.594	0.963	0.681
batch 2	0.907	0.803	0.858	0.668

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.5
HGNC	HGNC:2918
MGI	MGI:101926
EntrezGene (human)	GeneID:1749 (SSTAR profile)
EntrezGene (mouse)	GeneID:13395 (SSTAR profile)
UniProt ID (human)	DLX5_HUMAN
UniProt ID (mouse)	DLX5_MOUSE
UniProt AC (human)	P56178 (TFClass)
UniProt AC (mouse)	P70396 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 3 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	DLX5.H12INVIVO.0.PSM.A.pcm
PWM	DLX5.H12INVIVO.0.PSM.A.pwm
PFM	DLX5.H12INVIVO.0.PSM.A.pfm
Alignment	DLX5.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	DLX5.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	DLX5.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	DLX5.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	DLX5.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	DLX5.H12INVIVO.0.PSM.A_homer_format_0.001.txt DLX5.H12INVIVO.0.PSM.A_homer_format_0.0005.txt DLX5.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	78.0	313.0	443.0	165.0
02	292.0	357.0	114.0	236.0
03	92.0	75.0	11.0	821.0
04	934.0	26.0	30.0	9.0
05	967.0	14.0	8.0	10.0
06	8.0	9.0	14.0	968.0
07	8.0	18.0	107.0	866.0
08	654.0	12.0	312.0	21.0
09	141.0	627.0	111.0	120.0
10	530.0	69.0	31.0	369.0
11	139.0	105.0	537.0	218.0
12	124.0	314.0	256.0	305.0

PFM

	A	C	G	T
01	0.078	0.313	0.443	0.165
02	0.292	0.357	0.114	0.236
03	0.092	0.075	0.011	0.822
04	0.935	0.026	0.03	0.009
05	0.968	0.014	0.008	0.01
06	0.008	0.009	0.014	0.969
07	0.008	0.018	0.107	0.867
08	0.655	0.012	0.312	0.021
09	0.141	0.628	0.111	0.12
10	0.531	0.069	0.031	0.369
11	0.139	0.105	0.538	0.218
12	0.124	0.314	0.256	0.305

PWM

	A	C	G	T
01	-1.149	0.224	0.57	-0.411
02	0.155	0.355	-0.776	-0.056
03	-0.987	-1.187	-2.984	1.185
04	1.314	-2.205	-2.07	-3.155
05	1.349	-2.772	-3.252	-3.065
06	-3.252	-3.155	-2.772	1.35
07	-3.252	-2.545	-0.839	1.239
08	0.958	-2.908	0.221	-2.404
09	-0.566	0.916	-0.802	-0.726
10	0.749	-1.269	-2.039	0.388
11	-0.581	-0.857	0.762	-0.135
12	-0.693	0.228	0.025	0.199

Standard thresholds

P-value	Threshold
0.001	4.698115
0.0005	5.577565
0.0001	7.3679