DLX4.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX4.H12RSNP.0.SM.B
Gene (human)	DLX4 (GeneCards)
Gene synonyms (human)	BP1, DLX7, DLX8, DLX9
Gene (mouse)	Dlx4
Gene synonyms (mouse)	Dlx7
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	nvhTAATTRSnnn
GC content	35.75%
Information content (bits; total / per base)	11.57 / 0.89
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9488

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.983	0.971	0.977	0.96	0.962	0.943
Overall, 8 experiments	best	0.995	0.991	0.993	0.987	0.99	0.984
Methyl HT-SELEX, 3 experiments	median	0.983	0.971	0.975	0.958	0.96	0.939
Methyl HT-SELEX, 3 experiments	best	0.995	0.991	0.993	0.987	0.989	0.983
Non-Methyl HT-SELEX, 5 experiments	median	0.983	0.97	0.978	0.963	0.965	0.946
Non-Methyl HT-SELEX, 5 experiments	best	0.994	0.991	0.993	0.987	0.99	0.984

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.992	0.757	0.952	0.607
batch 2	0.945	0.839	0.853	0.631

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.4
HGNC	HGNC:2917
MGI	MGI:94904
EntrezGene (human)	GeneID:1748 (SSTAR profile)
EntrezGene (mouse)	GeneID:13394 (SSTAR profile)
UniProt ID (human)	DLX4_HUMAN
UniProt ID (mouse)	DLX4_MOUSE
UniProt AC (human)	Q92988 (TFClass)
UniProt AC (mouse)	P70436 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	DLX4.H12RSNP.0.SM.B.pcm
PWM	DLX4.H12RSNP.0.SM.B.pwm
PFM	DLX4.H12RSNP.0.SM.B.pfm
Alignment	DLX4.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	DLX4.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	DLX4.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	DLX4.H12RSNP.0.SM.B_meme_format.meme
Transfac format	DLX4.H12RSNP.0.SM.B_transfac_format.txt
Homer format	DLX4.H12RSNP.0.SM.B_homer_format_0.001.txt DLX4.H12RSNP.0.SM.B_homer_format_0.0005.txt DLX4.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2609.25	2644.25	2163.25	2071.25
02	2140.0	2466.0	3906.0	976.0
03	1694.0	3398.0	1470.0	2926.0
04	0.0	40.0	0.0	9448.0
05	9488.0	0.0	0.0	0.0
06	9488.0	0.0	0.0	0.0
07	0.0	0.0	0.0	9488.0
08	0.0	18.0	62.0	9408.0
09	4972.0	11.0	4484.0	21.0
10	836.0	5110.0	2861.0	681.0
11	1822.0	2702.0	2554.0	2410.0
12	1602.75	3143.75	2588.75	2152.75
13	2404.5	2353.5	2122.5	2607.5

PFM

	A	C	G	T
01	0.275	0.279	0.228	0.218
02	0.226	0.26	0.412	0.103
03	0.179	0.358	0.155	0.308
04	0.0	0.004	0.0	0.996
05	1.0	0.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.002	0.007	0.992
09	0.524	0.001	0.473	0.002
10	0.088	0.539	0.302	0.072
11	0.192	0.285	0.269	0.254
12	0.169	0.331	0.273	0.227
13	0.253	0.248	0.224	0.275

PWM

	A	C	G	T
01	0.095	0.109	-0.092	-0.135
02	-0.103	0.039	0.498	-0.887
03	-0.336	0.359	-0.478	0.21
04	-6.944	-4.028	-6.944	1.381
05	1.386	-6.944	-6.944	-6.944
06	1.386	-6.944	-6.944	-6.944
07	-6.944	-6.944	-6.944	1.386
08	-6.944	-4.762	-3.609	1.377
09	0.74	-5.185	0.636	-4.624
10	-1.041	0.767	0.187	-1.246
11	-0.264	0.13	0.074	0.016
12	-0.392	0.281	0.087	-0.097
13	0.014	-0.008	-0.111	0.095

Standard thresholds

P-value	Threshold
0.001	2.33691
0.0005	4.11643
0.0001	8.063265