DLX4.H12CORE.1.S.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX4.H12CORE.1.S.C
Gene (human)	DLX4 (GeneCards)
Gene synonyms (human)	BP1, DLX7, DLX8, DLX9
Gene (mouse)	Dlx4
Gene synonyms (mouse)	Dlx7
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	C

Motif length	18
Consensus	hWWWKdnvbTAATTAvnn
GC content	27.78%
Information content (bits; total / per base)	14.58 / 0.81
Data sources	HT-SELEX
Aligned words	341

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.967	0.946	0.961	0.933	0.945	0.915
Overall, 8 experiments	best	0.987	0.977	0.982	0.969	0.976	0.961
Methyl HT-SELEX, 3 experiments	median	0.973	0.953	0.963	0.939	0.947	0.919
Methyl HT-SELEX, 3 experiments	best	0.987	0.977	0.982	0.969	0.976	0.961
Non-Methyl HT-SELEX, 5 experiments	median	0.961	0.938	0.96	0.927	0.943	0.911
Non-Methyl HT-SELEX, 5 experiments	best	0.98	0.965	0.976	0.958	0.973	0.953

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.952	0.329	0.929	0.53
batch 2	0.88	0.707	0.833	0.598

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.4
HGNC	HGNC:2917
MGI	MGI:94904
EntrezGene (human)	GeneID:1748 (SSTAR profile)
EntrezGene (mouse)	GeneID:13394 (SSTAR profile)
UniProt ID (human)	DLX4_HUMAN
UniProt ID (mouse)	DLX4_MOUSE
UniProt AC (human)	Q92988 (TFClass)
UniProt AC (mouse)	P70436 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	DLX4.H12CORE.1.S.C.pcm
PWM	DLX4.H12CORE.1.S.C.pwm
PFM	DLX4.H12CORE.1.S.C.pfm
Alignment	DLX4.H12CORE.1.S.C.words.tsv
Threshold to P-value map	DLX4.H12CORE.1.S.C.thr
Motif in other formats
JASPAR format	DLX4.H12CORE.1.S.C_jaspar_format.txt
MEME format	DLX4.H12CORE.1.S.C_meme_format.meme
Transfac format	DLX4.H12CORE.1.S.C_transfac_format.txt
Homer format	DLX4.H12CORE.1.S.C_homer_format_0.001.txt DLX4.H12CORE.1.S.C_homer_format_0.0005.txt DLX4.H12CORE.1.S.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	135.75	44.75	31.75	128.75
02	180.75	37.75	4.75	117.75
03	199.0	5.0	5.0	132.0
04	139.0	6.0	19.0	177.0
05	65.0	9.0	72.0	195.0
06	57.0	41.0	91.0	152.0
07	137.0	47.0	110.0	47.0
08	100.0	70.0	129.0	42.0
09	23.0	94.0	160.0	64.0
10	0.0	13.0	0.0	328.0
11	341.0	0.0	0.0	0.0
12	341.0	0.0	0.0	0.0
13	0.0	0.0	0.0	341.0
14	0.0	0.0	0.0	341.0
15	249.0	0.0	92.0	0.0
16	54.0	129.0	117.0	41.0
17	89.75	92.75	100.75	57.75
18	100.25	80.25	103.25	57.25

PFM

	A	C	G	T
01	0.398	0.131	0.093	0.378
02	0.53	0.111	0.014	0.345
03	0.584	0.015	0.015	0.387
04	0.408	0.018	0.056	0.519
05	0.191	0.026	0.211	0.572
06	0.167	0.12	0.267	0.446
07	0.402	0.138	0.323	0.138
08	0.293	0.205	0.378	0.123
09	0.067	0.276	0.469	0.188
10	0.0	0.038	0.0	0.962
11	1.0	0.0	0.0	0.0
12	1.0	0.0	0.0	0.0
13	0.0	0.0	0.0	1.0
14	0.0	0.0	0.0	1.0
15	0.73	0.0	0.27	0.0
16	0.158	0.378	0.343	0.12
17	0.263	0.272	0.295	0.169
18	0.294	0.235	0.303	0.168

PWM

	A	C	G	T
01	0.459	-0.629	-0.96	0.407
02	0.743	-0.794	-2.637	0.318
03	0.838	-2.597	-2.597	0.431
04	0.482	-2.453	-1.444	0.722
05	-0.266	-2.115	-0.166	0.818
06	-0.394	-0.714	0.064	0.571
07	0.468	-0.582	0.251	-0.582
08	0.157	-0.193	0.409	-0.691
09	-1.266	0.096	0.622	-0.281
10	-4.086	-1.791	-4.086	1.335
11	1.374	-4.086	-4.086	-4.086
12	1.374	-4.086	-4.086	-4.086
13	-4.086	-4.086	-4.086	1.374
14	-4.086	-4.086	-4.086	1.374
15	1.061	-4.086	0.075	-4.086
16	-0.447	0.409	0.312	-0.714
17	0.051	0.083	0.164	-0.381
18	0.16	-0.059	0.189	-0.39

Standard thresholds

P-value	Threshold
0.001	2.87476
0.0005	4.13081
0.0001	6.78331