DLX2.H12INVITRO.1.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX2.H12INVITRO.1.S.B
Gene (human)	DLX2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx2
Gene synonyms (mouse)	Tes-1, Tes1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	18
Consensus	hWWWWdvvvTAATTAvbn
GC content	28.52%
Information content (bits; total / per base)	15.499 / 0.861
Data sources	HT-SELEX
Aligned words	2249

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	3 (21)	0.821	0.841	0.706	0.735	0.8	0.824	2.654	2.809	103.036	149.456

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.973	0.953	0.966	0.941	0.949	0.922
Overall, 8 experiments	best	0.993	0.987	0.989	0.982	0.978	0.968
Methyl HT-SELEX, 2 experiments	median	0.977	0.961	0.97	0.95	0.96	0.936
Methyl HT-SELEX, 2 experiments	best	0.983	0.97	0.978	0.962	0.971	0.952
Non-Methyl HT-SELEX, 6 experiments	median	0.973	0.952	0.953	0.932	0.89	0.866
Non-Methyl HT-SELEX, 6 experiments	best	0.993	0.987	0.989	0.982	0.978	0.968

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.786	0.71	0.794	0.634

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.2
HGNC	HGNC:2915
MGI	MGI:94902
EntrezGene (human)	GeneID:1746 (SSTAR profile)
EntrezGene (mouse)	GeneID:13392 (SSTAR profile)
UniProt ID (human)	DLX2_HUMAN
UniProt ID (mouse)	DLX2_MOUSE
UniProt AC (human)	Q07687 (TFClass)
UniProt AC (mouse)	P40764 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 3 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	DLX2.H12INVITRO.1.S.B.pcm
PWM	DLX2.H12INVITRO.1.S.B.pwm
PFM	DLX2.H12INVITRO.1.S.B.pfm
Alignment	DLX2.H12INVITRO.1.S.B.words.tsv
Threshold to P-value map	DLX2.H12INVITRO.1.S.B.thr
Motif in other formats
JASPAR format	DLX2.H12INVITRO.1.S.B_jaspar_format.txt
MEME format	DLX2.H12INVITRO.1.S.B_meme_format.meme
Transfac format	DLX2.H12INVITRO.1.S.B_transfac_format.txt
Homer format	DLX2.H12INVITRO.1.S.B_homer_format_0.001.txt DLX2.H12INVITRO.1.S.B_homer_format_0.0005.txt DLX2.H12INVITRO.1.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1027.0	238.0	141.0	843.0
02	1255.5	67.5	15.5	910.5
03	1311.0	12.0	24.0	902.0
04	836.0	32.0	134.0	1247.0
05	589.0	130.0	261.0	1269.0
06	646.0	237.0	634.0	732.0
07	677.0	631.0	790.0	151.0
08	697.0	580.0	744.0	228.0
09	163.0	885.0	1040.0	161.0
10	0.0	191.0	0.0	2058.0
11	2249.0	0.0	0.0	0.0
12	2249.0	0.0	0.0	0.0
13	0.0	0.0	0.0	2249.0
14	0.0	0.0	0.0	2249.0
15	1855.0	0.0	394.0	0.0
16	260.0	1021.0	881.0	87.0
17	266.75	908.75	351.75	721.75
18	369.75	757.75	444.75	676.75

PFM

	A	C	G	T
01	0.457	0.106	0.063	0.375
02	0.558	0.03	0.007	0.405
03	0.583	0.005	0.011	0.401
04	0.372	0.014	0.06	0.554
05	0.262	0.058	0.116	0.564
06	0.287	0.105	0.282	0.325
07	0.301	0.281	0.351	0.067
08	0.31	0.258	0.331	0.101
09	0.072	0.394	0.462	0.072
10	0.0	0.085	0.0	0.915
11	1.0	0.0	0.0	0.0
12	1.0	0.0	0.0	0.0
13	0.0	0.0	0.0	1.0
14	0.0	0.0	0.0	1.0
15	0.825	0.0	0.175	0.0
16	0.116	0.454	0.392	0.039
17	0.119	0.404	0.156	0.321
18	0.164	0.337	0.198	0.301

PWM

	A	C	G	T
01	0.601	-0.855	-1.373	0.404
02	0.801	-2.095	-3.477	0.481
03	0.845	-3.701	-3.08	0.471
04	0.396	-2.811	-1.423	0.795
05	0.046	-1.453	-0.763	0.812
06	0.138	-0.859	0.12	0.263
07	0.185	0.115	0.339	-1.305
08	0.214	0.031	0.279	-0.898
09	-1.23	0.452	0.613	-1.242
10	-5.678	-1.073	-5.678	1.295
11	1.384	-5.678	-5.678	-5.678
12	1.384	-5.678	-5.678	-5.678
13	-5.678	-5.678	-5.678	1.384
14	-5.678	-5.678	-5.678	1.384
15	1.191	-5.678	-0.354	-5.678
16	-0.767	0.595	0.448	-1.848
17	-0.742	0.479	-0.467	0.249
18	-0.417	0.298	-0.234	0.185

Standard thresholds

P-value	Threshold
0.001	1.05481
0.0005	2.63871
0.0001	6.12826