DLX2.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX2.H12INVITRO.0.PSM.A
Gene (human)	DLX2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx2
Gene synonyms (mouse)	Tes-1, Tes1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	14
Consensus	nvShTAATTACbbn
GC content	39.16%
Information content (bits; total / per base)	14.112 / 1.008
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	6055

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	3 (21)	0.832	0.849	0.721	0.76	0.827	0.843	2.653	2.753	119.569	147.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.989	0.981	0.983	0.972	0.97	0.956
Overall, 8 experiments	best	0.993	0.988	0.989	0.982	0.984	0.975
Methyl HT-SELEX, 2 experiments	median	0.991	0.984	0.986	0.977	0.977	0.965
Methyl HT-SELEX, 2 experiments	best	0.993	0.988	0.989	0.982	0.984	0.975
Non-Methyl HT-SELEX, 6 experiments	median	0.977	0.961	0.962	0.943	0.915	0.897
Non-Methyl HT-SELEX, 6 experiments	best	0.991	0.985	0.986	0.977	0.976	0.962

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.806	0.765	0.812	0.654

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.2
HGNC	HGNC:2915
MGI	MGI:94902
EntrezGene (human)	GeneID:1746 (SSTAR profile)
EntrezGene (mouse)	GeneID:13392 (SSTAR profile)
UniProt ID (human)	DLX2_HUMAN
UniProt ID (mouse)	DLX2_MOUSE
UniProt AC (human)	Q07687 (TFClass)
UniProt AC (mouse)	P40764 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 3 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	DLX2.H12INVITRO.0.PSM.A.pcm
PWM	DLX2.H12INVITRO.0.PSM.A.pwm
PFM	DLX2.H12INVITRO.0.PSM.A.pfm
Alignment	DLX2.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	DLX2.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	DLX2.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	DLX2.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	DLX2.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	DLX2.H12INVITRO.0.PSM.A_homer_format_0.001.txt DLX2.H12INVITRO.0.PSM.A_homer_format_0.0005.txt DLX2.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1618.25	1374.25	1868.25	1194.25
02	1544.5	2864.5	962.5	683.5
03	847.0	1156.0	3990.0	62.0
04	2481.0	2016.0	747.0	811.0
05	0.0	0.0	0.0	6055.0
06	6055.0	0.0	0.0	0.0
07	6055.0	0.0	0.0	0.0
08	0.0	0.0	0.0	6055.0
09	0.0	0.0	0.0	6055.0
10	5479.0	0.0	576.0	0.0
11	12.0	4712.0	1233.0	98.0
12	903.0	2132.0	1980.0	1040.0
13	613.75	2821.75	1666.75	952.75
14	1314.25	1816.25	1277.25	1647.25

PFM

	A	C	G	T
01	0.267	0.227	0.309	0.197
02	0.255	0.473	0.159	0.113
03	0.14	0.191	0.659	0.01
04	0.41	0.333	0.123	0.134
05	0.0	0.0	0.0	1.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.0	0.0	1.0
10	0.905	0.0	0.095	0.0
11	0.002	0.778	0.204	0.016
12	0.149	0.352	0.327	0.172
13	0.101	0.466	0.275	0.157
14	0.217	0.3	0.211	0.272

PWM

	A	C	G	T
01	0.067	-0.097	0.21	-0.237
02	0.02	0.637	-0.452	-0.793
03	-0.58	-0.269	0.968	-3.162
04	0.494	0.286	-0.705	-0.623
05	-6.546	-6.546	-6.546	1.385
06	1.385	-6.546	-6.546	-6.546
07	1.385	-6.546	-6.546	-6.546
08	-6.546	-6.546	-6.546	1.385
09	-6.546	-6.546	-6.546	1.385
10	1.285	-6.546	-0.964	-6.546
11	-4.672	1.135	-0.205	-2.717
12	-0.516	0.342	0.268	-0.375
13	-0.901	0.622	0.096	-0.462
14	-0.141	0.182	-0.17	0.084

Standard thresholds

P-value	Threshold
0.001	0.798265
0.0005	2.17121
0.0001	6.946865