DLX1.H12RSNP.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX1.H12RSNP.1.PSM.A
Gene (human)	DLX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	11
Consensus	nvnTAATTRbn
GC content	29.69%
Information content (bits; total / per base)	11.088 / 1.008
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	6442

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.685	0.701	0.63	0.639	0.635	0.654	2.011	2.085	35.056	73.444

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.979	0.963	0.975	0.956	0.952	0.935
Overall, 10 experiments	best	0.991	0.987	0.984	0.973	0.975	0.961
Methyl HT-SELEX, 3 experiments	median	0.978	0.963	0.973	0.954	0.951	0.93
Methyl HT-SELEX, 3 experiments	best	0.982	0.969	0.978	0.961	0.972	0.953
Non-Methyl HT-SELEX, 7 experiments	median	0.98	0.963	0.976	0.959	0.953	0.941
Non-Methyl HT-SELEX, 7 experiments	best	0.991	0.987	0.984	0.973	0.975	0.961

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.995	0.769	0.967	0.542
batch 2	0.928	0.78	0.852	0.596

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.1
HGNC	HGNC:2914
MGI	MGI:94901
EntrezGene (human)	GeneID:1745 (SSTAR profile)
EntrezGene (mouse)	GeneID:13390 (SSTAR profile)
UniProt ID (human)	DLX1_HUMAN
UniProt ID (mouse)	DLX1_MOUSE
UniProt AC (human)	P56177 (TFClass)
UniProt AC (mouse)	Q64317 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	DLX1.H12RSNP.1.PSM.A.pcm
PWM	DLX1.H12RSNP.1.PSM.A.pwm
PFM	DLX1.H12RSNP.1.PSM.A.pfm
Alignment	DLX1.H12RSNP.1.PSM.A.words.tsv
Threshold to P-value map	DLX1.H12RSNP.1.PSM.A.thr
Motif in other formats
JASPAR format	DLX1.H12RSNP.1.PSM.A_jaspar_format.txt
MEME format	DLX1.H12RSNP.1.PSM.A_meme_format.meme
Transfac format	DLX1.H12RSNP.1.PSM.A_transfac_format.txt
Homer format	DLX1.H12RSNP.1.PSM.A_homer_format_0.001.txt DLX1.H12RSNP.1.PSM.A_homer_format_0.0005.txt DLX1.H12RSNP.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1776.0	1455.0	1764.0	1447.0
02	1313.0	1916.0	2526.0	687.0
03	1418.0	1690.0	1173.0	2161.0
04	0.0	0.0	0.0	6442.0
05	6442.0	0.0	0.0	0.0
06	6442.0	0.0	0.0	0.0
07	0.0	0.0	0.0	6442.0
08	0.0	0.0	16.0	6426.0
09	3071.0	34.0	2899.0	438.0
10	396.75	2175.75	2610.75	1258.75
11	1506.25	1325.25	1451.25	2159.25

PFM

	A	C	G	T
01	0.276	0.226	0.274	0.225
02	0.204	0.297	0.392	0.107
03	0.22	0.262	0.182	0.335
04	0.0	0.0	0.0	1.0
05	1.0	0.0	0.0	0.0
06	1.0	0.0	0.0	0.0
07	0.0	0.0	0.0	1.0
08	0.0	0.0	0.002	0.998
09	0.477	0.005	0.45	0.068
10	0.062	0.338	0.405	0.195
11	0.234	0.206	0.225	0.335

PWM

	A	C	G	T
01	0.098	-0.101	0.091	-0.107
02	-0.204	0.173	0.45	-0.85
03	-0.127	0.048	-0.316	0.294
04	-6.601	-6.601	-6.601	1.385
05	1.385	-6.601	-6.601	-6.601
06	1.385	-6.601	-6.601	-6.601
07	-6.601	-6.601	-6.601	1.385
08	-6.601	-6.601	-4.485	1.383
09	0.645	-3.797	0.587	-1.298
10	-1.397	0.3	0.483	-0.246
11	-0.067	-0.195	-0.104	0.293

Standard thresholds

P-value	Threshold
0.001	2.20605
0.0005	5.94136
0.0001	8.011125