DLX1.H12INVIVO.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX1.H12INVIVO.1.PSM.A
Gene (human)	DLX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	14
Consensus	nvvbTAATTACnbn
GC content	39.02%
Information content (bits; total / per base)	13.587 / 0.971
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	7008

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.704	0.714	0.627	0.657	0.637	0.644	2.093	2.148	48.444	80.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.984	0.972	0.979	0.964	0.954	0.938
Overall, 10 experiments	best	0.99	0.981	0.986	0.975	0.975	0.962
Methyl HT-SELEX, 3 experiments	median	0.983	0.969	0.976	0.96	0.951	0.933
Methyl HT-SELEX, 3 experiments	best	0.986	0.974	0.981	0.968	0.974	0.957
Non-Methyl HT-SELEX, 7 experiments	median	0.986	0.975	0.981	0.968	0.957	0.944
Non-Methyl HT-SELEX, 7 experiments	best	0.99	0.981	0.986	0.975	0.975	0.962

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.991	0.687	0.959	0.457
batch 2	0.895	0.75	0.846	0.618

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.1
HGNC	HGNC:2914
MGI	MGI:94901
EntrezGene (human)	GeneID:1745 (SSTAR profile)
EntrezGene (mouse)	GeneID:13390 (SSTAR profile)
UniProt ID (human)	DLX1_HUMAN
UniProt ID (mouse)	DLX1_MOUSE
UniProt AC (human)	P56177 (TFClass)
UniProt AC (mouse)	Q64317 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	DLX1.H12INVIVO.1.PSM.A.pcm
PWM	DLX1.H12INVIVO.1.PSM.A.pwm
PFM	DLX1.H12INVIVO.1.PSM.A.pfm
Alignment	DLX1.H12INVIVO.1.PSM.A.words.tsv
Threshold to P-value map	DLX1.H12INVIVO.1.PSM.A.thr
Motif in other formats
JASPAR format	DLX1.H12INVIVO.1.PSM.A_jaspar_format.txt
MEME format	DLX1.H12INVIVO.1.PSM.A_meme_format.meme
Transfac format	DLX1.H12INVIVO.1.PSM.A_transfac_format.txt
Homer format	DLX1.H12INVIVO.1.PSM.A_homer_format_0.001.txt DLX1.H12INVIVO.1.PSM.A_homer_format_0.0005.txt DLX1.H12INVIVO.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1848.75	1780.75	1688.75	1689.75
02	1860.75	2811.75	1176.75	1158.75
03	1285.0	2441.0	2806.0	476.0
04	896.0	3863.0	1037.0	1212.0
05	0.0	0.0	0.0	7008.0
06	7008.0	0.0	0.0	0.0
07	7008.0	0.0	0.0	0.0
08	0.0	0.0	0.0	7008.0
09	0.0	0.0	0.0	7008.0
10	5529.0	0.0	1479.0	0.0
11	47.0	6176.0	776.0	9.0
12	1200.0	2616.0	1717.0	1475.0
13	759.25	3195.25	1390.25	1663.25
14	1656.5	2078.5	1252.5	2020.5

PFM

	A	C	G	T
01	0.264	0.254	0.241	0.241
02	0.266	0.401	0.168	0.165
03	0.183	0.348	0.4	0.068
04	0.128	0.551	0.148	0.173
05	0.0	0.0	0.0	1.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.0	0.0	1.0
10	0.789	0.0	0.211	0.0
11	0.007	0.881	0.111	0.001
12	0.171	0.373	0.245	0.21
13	0.108	0.456	0.198	0.237
14	0.236	0.297	0.179	0.288

PWM

	A	C	G	T
01	0.054	0.016	-0.037	-0.036
02	0.06	0.473	-0.397	-0.413
03	-0.31	0.331	0.471	-1.3
04	-0.669	0.79	-0.524	-0.368
05	-6.675	-6.675	-6.675	1.385
06	1.385	-6.675	-6.675	-6.675
07	1.385	-6.675	-6.675	-6.675
08	-6.675	-6.675	-6.675	1.385
09	-6.675	-6.675	-6.675	1.385
10	1.148	-6.675	-0.169	-6.675
11	-3.574	1.259	-0.813	-5.053
12	-0.378	0.4	-0.02	-0.172
13	-0.835	0.6	-0.231	-0.052
14	-0.056	0.171	-0.335	0.142

Standard thresholds

P-value	Threshold
0.001	0.87561
0.0005	2.117765
0.0001	7.390765