DLX1.H12INVITRO.1.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	DLX1.H12INVITRO.1.PSM.A
Gene (human)	DLX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Dlx1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	11
Consensus	nvhTAATTRSn
GC content	32.28%
Information content (bits; total / per base)	11.781 / 1.071
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	8993

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.68	0.697	0.63	0.643	0.633	0.643	2.082	2.122	42.678	72.585

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.985	0.974	0.98	0.966	0.957	0.942
Overall, 10 experiments	best	0.992	0.986	0.988	0.98	0.977	0.966
Methyl HT-SELEX, 3 experiments	median	0.984	0.971	0.977	0.962	0.956	0.938
Methyl HT-SELEX, 3 experiments	best	0.988	0.979	0.984	0.973	0.975	0.961
Non-Methyl HT-SELEX, 7 experiments	median	0.986	0.976	0.982	0.969	0.959	0.946
Non-Methyl HT-SELEX, 7 experiments	best	0.992	0.986	0.988	0.98	0.977	0.966

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.978	0.546	0.946	0.528
batch 2	0.912	0.703	0.853	0.624

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	DLX {3.1.2.5} (TFClass)
TFClass ID	TFClass: 3.1.2.5.1
HGNC	HGNC:2914
MGI	MGI:94901
EntrezGene (human)	GeneID:1745 (SSTAR profile)
EntrezGene (mouse)	GeneID:13390 (SSTAR profile)
UniProt ID (human)	DLX1_HUMAN
UniProt ID (mouse)	DLX1_MOUSE
UniProt AC (human)	P56177 (TFClass)
UniProt AC (mouse)	Q64317 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	DLX1.H12INVITRO.1.PSM.A.pcm
PWM	DLX1.H12INVITRO.1.PSM.A.pwm
PFM	DLX1.H12INVITRO.1.PSM.A.pfm
Alignment	DLX1.H12INVITRO.1.PSM.A.words.tsv
Threshold to P-value map	DLX1.H12INVITRO.1.PSM.A.thr
Motif in other formats
JASPAR format	DLX1.H12INVITRO.1.PSM.A_jaspar_format.txt
MEME format	DLX1.H12INVITRO.1.PSM.A_meme_format.meme
Transfac format	DLX1.H12INVITRO.1.PSM.A_transfac_format.txt
Homer format	DLX1.H12INVITRO.1.PSM.A_homer_format_0.001.txt DLX1.H12INVITRO.1.PSM.A_homer_format_0.0005.txt DLX1.H12INVITRO.1.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2473.5	2568.5	2123.5	1827.5
02	1333.5	3333.5	3571.5	754.5
03	2566.0	3067.0	1077.0	2283.0
04	16.0	23.0	0.0	8954.0
05	8963.0	30.0	0.0	0.0
06	8988.0	5.0	0.0	0.0
07	0.0	5.0	0.0	8988.0
08	1.0	10.0	9.0	8973.0
09	5254.0	50.0	3689.0	0.0
10	729.5	5579.5	2297.5	386.5
11	2019.25	2477.25	2011.25	2485.25

PFM

	A	C	G	T
01	0.275	0.286	0.236	0.203
02	0.148	0.371	0.397	0.084
03	0.285	0.341	0.12	0.254
04	0.002	0.003	0.0	0.996
05	0.997	0.003	0.0	0.0
06	0.999	0.001	0.0	0.0
07	0.0	0.001	0.0	0.999
08	0.0	0.001	0.001	0.998
09	0.584	0.006	0.41	0.0
10	0.081	0.62	0.255	0.043
11	0.225	0.275	0.224	0.276

PWM

	A	C	G	T
01	0.095	0.133	-0.057	-0.207
02	-0.522	0.394	0.462	-1.09
03	0.132	0.31	-0.735	0.015
04	-4.813	-4.489	-6.896	1.381
05	1.382	-4.245	-6.896	-6.896
06	1.385	-5.734	-6.896	-6.896
07	-6.896	-5.734	-6.896	1.385
08	-6.532	-5.211	-5.296	1.383
09	0.848	-3.762	0.495	-6.896
10	-1.123	0.908	0.022	-1.756
11	-0.107	0.097	-0.111	0.1

Standard thresholds

P-value	Threshold
0.001	2.19835
0.0005	4.282195
0.0001	8.05699