CREM.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREM.H12INVIVO.0.PSM.A
Gene (human)	CREM (GeneCards)
Gene synonyms (human)
Gene (mouse)	Crem
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	ndRTGACGYvv
GC content	51.88%
Information content (bits; total / per base)	10.692 / 0.972
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.876	0.913	0.812	0.869	0.86	0.895	3.743	4.099	339.62	458.319

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.948	0.919	0.906	0.873	0.807	0.786
Overall, 2 experiments	best	0.951	0.926	0.924	0.891	0.836	0.811
Methyl HT-SELEX, 1 experiments	median	0.951	0.926	0.924	0.891	0.836	0.811
Methyl HT-SELEX, 1 experiments	best	0.951	0.926	0.924	0.891	0.836	0.811
Non-Methyl HT-SELEX, 1 experiments	median	0.945	0.912	0.889	0.855	0.777	0.761
Non-Methyl HT-SELEX, 1 experiments	best	0.945	0.912	0.889	0.855	0.777	0.761

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB-like {1.1.7.1} (TFClass)
TFClass ID	TFClass: 1.1.7.1.3
HGNC	HGNC:2352
MGI	MGI:88495
EntrezGene (human)	GeneID:1390 (SSTAR profile)
EntrezGene (mouse)	GeneID:12916 (SSTAR profile)
UniProt ID (human)	CREM_HUMAN
UniProt ID (mouse)	CREM_MOUSE
UniProt AC (human)	Q03060 (TFClass)
UniProt AC (mouse)	P27699 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	CREM.H12INVIVO.0.PSM.A.pcm
PWM	CREM.H12INVIVO.0.PSM.A.pwm
PFM	CREM.H12INVIVO.0.PSM.A.pfm
Alignment	CREM.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	CREM.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	CREM.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	CREM.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	CREM.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	CREM.H12INVIVO.0.PSM.A_homer_format_0.001.txt CREM.H12INVIVO.0.PSM.A_homer_format_0.0005.txt CREM.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	297.0	289.0	145.0	269.0
02	318.0	133.0	383.0	166.0
03	390.0	44.0	560.0	6.0
04	7.0	15.0	11.0	967.0
05	18.0	5.0	960.0	17.0
06	973.0	5.0	16.0	6.0
07	12.0	930.0	22.0	36.0
08	30.0	12.0	946.0	12.0
09	69.0	289.0	31.0	611.0
10	319.0	502.0	118.0	61.0
11	595.0	139.0	152.0	114.0

PFM

	A	C	G	T
01	0.297	0.289	0.145	0.269
02	0.318	0.133	0.383	0.166
03	0.39	0.044	0.56	0.006
04	0.007	0.015	0.011	0.967
05	0.018	0.005	0.96	0.017
06	0.973	0.005	0.016	0.006
07	0.012	0.93	0.022	0.036
08	0.03	0.012	0.946	0.012
09	0.069	0.289	0.031	0.611
10	0.319	0.502	0.118	0.061
11	0.595	0.139	0.152	0.114

PWM

	A	C	G	T
01	0.171	0.144	-0.54	0.073
02	0.239	-0.625	0.424	-0.406
03	0.442	-1.706	0.803	-3.484
04	-3.362	-2.711	-2.985	1.348
05	-2.546	-3.622	1.34	-2.598
06	1.354	-3.622	-2.653	-3.484
07	-2.909	1.309	-2.362	-1.898
08	-2.071	-2.909	1.326	-2.909
09	-1.27	0.144	-2.04	0.89
10	0.242	0.694	-0.743	-1.39
11	0.863	-0.582	-0.493	-0.777

Standard thresholds

P-value	Threshold
0.001	4.476245
0.0005	5.38622
0.0001	7.530065