CREM.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREM.H12INVITRO.0.PSM.A
Gene (human)	CREM (GeneCards)
Gene synonyms (human)
Gene (mouse)	Crem
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nRTGACGYvdn
GC content	52.33%
Information content (bits; total / per base)	10.677 / 0.971
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	9544

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.858	0.895	0.791	0.85	0.853	0.886	3.65	3.979	335.444	437.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.956	0.929	0.912	0.882	0.809	0.793
Overall, 2 experiments	best	0.959	0.936	0.934	0.904	0.851	0.827
Methyl HT-SELEX, 1 experiments	median	0.959	0.936	0.934	0.904	0.851	0.827
Methyl HT-SELEX, 1 experiments	best	0.959	0.936	0.934	0.904	0.851	0.827
Non-Methyl HT-SELEX, 1 experiments	median	0.952	0.923	0.89	0.86	0.768	0.758
Non-Methyl HT-SELEX, 1 experiments	best	0.952	0.923	0.89	0.86	0.768	0.758

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB-like {1.1.7.1} (TFClass)
TFClass ID	TFClass: 1.1.7.1.3
HGNC	HGNC:2352
MGI	MGI:88495
EntrezGene (human)	GeneID:1390 (SSTAR profile)
EntrezGene (mouse)	GeneID:12916 (SSTAR profile)
UniProt ID (human)	CREM_HUMAN
UniProt ID (mouse)	CREM_MOUSE
UniProt AC (human)	Q03060 (TFClass)
UniProt AC (mouse)	P27699 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	CREM.H12INVITRO.0.PSM.A.pcm
PWM	CREM.H12INVITRO.0.PSM.A.pwm
PFM	CREM.H12INVITRO.0.PSM.A.pfm
Alignment	CREM.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	CREM.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	CREM.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	CREM.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	CREM.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	CREM.H12INVITRO.0.PSM.A_homer_format_0.001.txt CREM.H12INVITRO.0.PSM.A_homer_format_0.0005.txt CREM.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1599.75	2631.75	3566.75	1745.75
02	4112.75	372.75	4858.75	199.75
03	3.0	24.0	72.0	9445.0
04	0.0	0.0	9485.0	59.0
05	9543.0	0.0	1.0	0.0
06	1.0	7585.0	288.0	1670.0
07	367.0	57.0	9115.0	5.0
08	373.0	2635.0	174.0	6362.0
09	2600.0	3427.0	2723.0	794.0
10	4628.75	1094.75	1952.75	1867.75
11	1391.5	2339.5	2538.5	3274.5

PFM

	A	C	G	T
01	0.168	0.276	0.374	0.183
02	0.431	0.039	0.509	0.021
03	0.0	0.003	0.008	0.99
04	0.0	0.0	0.994	0.006
05	1.0	0.0	0.0	0.0
06	0.0	0.795	0.03	0.175
07	0.038	0.006	0.955	0.001
08	0.039	0.276	0.018	0.667
09	0.272	0.359	0.285	0.083
10	0.485	0.115	0.205	0.196
11	0.146	0.245	0.266	0.343

PWM

	A	C	G	T
01	-0.399	0.098	0.402	-0.312
02	0.544	-1.851	0.711	-2.47
03	-6.112	-4.509	-3.47	1.375
04	-6.949	-6.949	1.379	-3.663
05	1.385	-6.949	-6.587	-6.949
06	-6.587	1.156	-2.107	-0.356
07	-1.867	-3.696	1.34	-5.792
08	-1.851	0.099	-2.606	0.98
09	0.086	0.362	0.132	-1.098
10	0.662	-0.778	-0.2	-0.245
11	-0.539	-0.02	0.062	0.316

Standard thresholds

P-value	Threshold
0.001	4.518975
0.0005	5.65228
0.0001	7.775775