CREM.H12CORE.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREM.H12CORE.0.PSM.A
Gene (human)	CREM (GeneCards)
Gene synonyms (human)
Gene (mouse)	Crem
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	10
Consensus	nRTGACGYvn
GC content	52.96%
Information content (bits; total / per base)	11.285 / 1.129
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	8983

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.874	0.913	0.813	0.861	0.832	0.88	3.232	3.533	325.046	468.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.957	0.933	0.904	0.876	0.804	0.785
Overall, 2 experiments	best	0.961	0.937	0.904	0.878	0.822	0.795
Methyl HT-SELEX, 1 experiments	median	0.954	0.929	0.903	0.874	0.822	0.795
Methyl HT-SELEX, 1 experiments	best	0.954	0.929	0.903	0.874	0.822	0.795
Non-Methyl HT-SELEX, 1 experiments	median	0.961	0.937	0.904	0.878	0.786	0.776
Non-Methyl HT-SELEX, 1 experiments	best	0.961	0.937	0.904	0.878	0.786	0.776

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB-like {1.1.7.1} (TFClass)
TFClass ID	TFClass: 1.1.7.1.3
HGNC	HGNC:2352
MGI	MGI:88495
EntrezGene (human)	GeneID:1390 (SSTAR profile)
EntrezGene (mouse)	GeneID:12916 (SSTAR profile)
UniProt ID (human)	CREM_HUMAN
UniProt ID (mouse)	CREM_MOUSE
UniProt AC (human)	Q03060 (TFClass)
UniProt AC (mouse)	P27699 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	CREM.H12CORE.0.PSM.A.pcm
PWM	CREM.H12CORE.0.PSM.A.pwm
PFM	CREM.H12CORE.0.PSM.A.pfm
Alignment	CREM.H12CORE.0.PSM.A.words.tsv
Threshold to P-value map	CREM.H12CORE.0.PSM.A.thr
Motif in other formats
JASPAR format	CREM.H12CORE.0.PSM.A_jaspar_format.txt
MEME format	CREM.H12CORE.0.PSM.A_meme_format.meme
Transfac format	CREM.H12CORE.0.PSM.A_transfac_format.txt
Homer format	CREM.H12CORE.0.PSM.A_homer_format_0.001.txt CREM.H12CORE.0.PSM.A_homer_format_0.0005.txt CREM.H12CORE.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1743.5	2742.5	2647.5	1849.5
02	3831.75	673.75	4059.75	417.75
03	2.0	35.0	82.0	8864.0
04	0.0	2.0	8881.0	100.0
05	8983.0	0.0	0.0	0.0
06	0.0	8976.0	6.0	1.0
07	21.0	35.0	8925.0	2.0
08	251.0	1930.0	218.0	6584.0
09	3555.75	1900.75	2365.75	1160.75
10	2975.0	1687.0	2407.0	1914.0

PFM

	A	C	G	T
01	0.194	0.305	0.295	0.206
02	0.427	0.075	0.452	0.047
03	0.0	0.004	0.009	0.987
04	0.0	0.0	0.989	0.011
05	1.0	0.0	0.0	0.0
06	0.0	0.999	0.001	0.0
07	0.002	0.004	0.994	0.0
08	0.028	0.215	0.024	0.733
09	0.396	0.212	0.263	0.129
10	0.331	0.188	0.268	0.213

PWM

	A	C	G	T
01	-0.253	0.2	0.164	-0.194
02	0.534	-1.202	0.592	-1.677
03	-6.265	-4.099	-3.284	1.372
04	-6.895	-6.265	1.374	-3.09
05	1.386	-6.895	-6.895	-6.895
06	-6.895	1.385	-5.604	-6.531
07	-4.57	-4.099	1.379	-6.265
08	-2.183	-0.151	-2.323	1.075
09	0.459	-0.167	0.052	-0.659
10	0.281	-0.286	0.069	-0.16

Standard thresholds

P-value	Threshold
0.001	3.5454
0.0005	5.2876
0.0001	7.9889