CREB5.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB5.H12RSNP.1.SM.B
Gene (human)	CREB5 (GeneCards)
Gene synonyms (human)	CREBPA
Gene (mouse)	Creb5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	18
Consensus	nvRTGACGTCATnvvbhn
GC content	47.38%
Information content (bits; total / per base)	18.642 / 1.036
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	379

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.512	0.52	0.366	0.385	0.676	0.748	2.136	2.533	104.368	157.244

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.984	0.975	0.962	0.947	0.894	0.882
Overall, 6 experiments	best	1.0	0.999	0.999	0.999	0.998	0.998
Methyl HT-SELEX, 2 experiments	median	0.997	0.996	0.993	0.99	0.975	0.969
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	0.999	0.999	0.997	0.995
Non-Methyl HT-SELEX, 4 experiments	median	0.88	0.882	0.775	0.783	0.69	0.702
Non-Methyl HT-SELEX, 4 experiments	best	1.0	0.999	0.999	0.999	0.998	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.99	0.86	0.959	0.576
batch 2	0.985	0.973	0.925	0.65

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.3
HGNC	HGNC:16844
MGI	MGI:2443973
EntrezGene (human)	GeneID:9586 (SSTAR profile)
EntrezGene (mouse)	GeneID:231991 (SSTAR profile)
UniProt ID (human)	CREB5_HUMAN
UniProt ID (mouse)	CREB5_MOUSE
UniProt AC (human)	Q02930 (TFClass)
UniProt AC (mouse)	Q8K1L0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	CREB5.H12RSNP.1.SM.B.pcm
PWM	CREB5.H12RSNP.1.SM.B.pwm
PFM	CREB5.H12RSNP.1.SM.B.pfm
Alignment	CREB5.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	CREB5.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	CREB5.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	CREB5.H12RSNP.1.SM.B_meme_format.meme
Transfac format	CREB5.H12RSNP.1.SM.B_transfac_format.txt
Homer format	CREB5.H12RSNP.1.SM.B_homer_format_0.001.txt CREB5.H12RSNP.1.SM.B_homer_format_0.0005.txt CREB5.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	121.75	80.75	92.75	83.75
02	106.0	71.0	148.0	54.0
03	254.0	16.0	101.0	8.0
04	0.0	1.0	0.0	378.0
05	0.0	0.0	361.0	18.0
06	379.0	0.0	0.0	0.0
07	0.0	379.0	0.0	0.0
08	0.0	0.0	379.0	0.0
09	0.0	0.0	0.0	379.0
10	30.0	349.0	0.0	0.0
11	379.0	0.0	0.0	0.0
12	2.0	13.0	10.0	354.0
13	58.0	91.0	99.0	131.0
14	182.0	93.0	63.0	41.0
15	49.0	207.0	75.0	48.0
16	37.0	106.0	165.0	71.0
17	76.75	86.75	61.75	153.75
18	85.5	103.5	79.5	110.5

PFM

	A	C	G	T
01	0.321	0.213	0.245	0.221
02	0.28	0.187	0.391	0.142
03	0.67	0.042	0.266	0.021
04	0.0	0.003	0.0	0.997
05	0.0	0.0	0.953	0.047
06	1.0	0.0	0.0	0.0
07	0.0	1.0	0.0	0.0
08	0.0	0.0	1.0	0.0
09	0.0	0.0	0.0	1.0
10	0.079	0.921	0.0	0.0
11	1.0	0.0	0.0	0.0
12	0.005	0.034	0.026	0.934
13	0.153	0.24	0.261	0.346
14	0.48	0.245	0.166	0.108
15	0.129	0.546	0.198	0.127
16	0.098	0.28	0.435	0.187
17	0.203	0.229	0.163	0.406
18	0.226	0.273	0.21	0.292

PWM

	A	C	G	T
01	0.247	-0.157	-0.021	-0.121
02	0.111	-0.283	0.44	-0.551
03	0.976	-1.705	0.063	-2.317
04	-4.172	-3.657	-4.172	1.372
05	-4.172	-4.172	1.326	-1.597
06	1.375	-4.172	-4.172	-4.172
07	-4.172	1.375	-4.172	-4.172
08	-4.172	-4.172	1.375	-4.172
09	-4.172	-4.172	-4.172	1.375
10	-1.117	1.293	-4.172	-4.172
11	1.375	-4.172	-4.172	-4.172
12	-3.318	-1.894	-2.126	1.307
13	-0.481	-0.04	0.043	0.32
14	0.645	-0.018	-0.4	-0.818
15	-0.645	0.773	-0.23	-0.665
16	-0.917	0.111	0.548	-0.283
17	-0.207	-0.087	-0.42	0.478
18	-0.101	0.087	-0.173	0.152

Standard thresholds

P-value	Threshold
0.001	0.22746
0.0005	1.75201
0.0001	4.97551