CREB5.H12INVIVO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB5.H12INVIVO.1.SM.B
Gene (human)	CREB5 (GeneCards)
Gene synonyms (human)	CREBPA
Gene (mouse)	Creb5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	12
Consensus	nvATGAYGTMAb
GC content	44.51%
Information content (bits; total / per base)	13.97 / 1.164
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9471

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.764	0.822	0.689	0.752	0.716	0.782	2.409	2.786	150.695	234.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.984	0.974	0.964	0.951	0.904	0.893
Overall, 6 experiments	best	1.0	0.999	1.0	0.999	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.998	0.997	0.997	0.995	0.983	0.98
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	1.0	0.999	0.999	0.999
Non-Methyl HT-SELEX, 4 experiments	median	0.887	0.887	0.778	0.785	0.692	0.705
Non-Methyl HT-SELEX, 4 experiments	best	1.0	0.999	0.999	0.999	0.998	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.873	0.529	0.835	0.515
batch 2	0.927	0.847	0.863	0.565

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.3
HGNC	HGNC:16844
MGI	MGI:2443973
EntrezGene (human)	GeneID:9586 (SSTAR profile)
EntrezGene (mouse)	GeneID:231991 (SSTAR profile)
UniProt ID (human)	CREB5_HUMAN
UniProt ID (mouse)	CREB5_MOUSE
UniProt AC (human)	Q02930 (TFClass)
UniProt AC (mouse)	Q8K1L0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	CREB5.H12INVIVO.1.SM.B.pcm
PWM	CREB5.H12INVIVO.1.SM.B.pwm
PFM	CREB5.H12INVIVO.1.SM.B.pfm
Alignment	CREB5.H12INVIVO.1.SM.B.words.tsv
Threshold to P-value map	CREB5.H12INVIVO.1.SM.B.thr
Motif in other formats
JASPAR format	CREB5.H12INVIVO.1.SM.B_jaspar_format.txt
MEME format	CREB5.H12INVIVO.1.SM.B_meme_format.meme
Transfac format	CREB5.H12INVIVO.1.SM.B_transfac_format.txt
Homer format	CREB5.H12INVIVO.1.SM.B_homer_format_0.001.txt CREB5.H12INVIVO.1.SM.B_homer_format_0.0005.txt CREB5.H12INVIVO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1397.75	2554.75	2584.75	2933.75
02	2093.75	1381.75	4843.75	1151.75
03	6896.0	29.0	2526.0	20.0
04	0.0	36.0	1.0	9434.0
05	0.0	0.0	9013.0	458.0
06	9462.0	0.0	1.0	8.0
07	4.0	6643.0	263.0	2561.0
08	431.0	31.0	9009.0	0.0
09	45.0	76.0	6.0	9344.0
10	3310.0	5988.0	118.0	55.0
11	7687.0	329.0	1132.0	323.0
12	588.25	2636.25	1384.25	4862.25

PFM

	A	C	G	T
01	0.148	0.27	0.273	0.31
02	0.221	0.146	0.511	0.122
03	0.728	0.003	0.267	0.002
04	0.0	0.004	0.0	0.996
05	0.0	0.0	0.952	0.048
06	0.999	0.0	0.0	0.001
07	0.0	0.701	0.028	0.27
08	0.046	0.003	0.951	0.0
09	0.005	0.008	0.001	0.987
10	0.349	0.632	0.012	0.006
11	0.812	0.035	0.12	0.034
12	0.062	0.278	0.146	0.513

PWM

	A	C	G	T
01	-0.526	0.076	0.088	0.214
02	-0.123	-0.538	0.715	-0.72
03	1.068	-4.327	0.065	-4.667
04	-6.943	-4.125	-6.58	1.382
05	-6.943	-6.943	1.336	-1.639
06	1.385	-6.943	-6.58	-5.44
07	-5.932	1.031	-2.19	0.078
08	-1.699	-4.265	1.336	-6.943
09	-3.914	-3.41	-5.656	1.372
10	0.335	0.927	-2.981	-3.723
11	1.177	-1.968	-0.737	-1.986
12	-1.39	0.107	-0.536	0.719

Standard thresholds

P-value	Threshold
0.001	2.278585
0.0005	3.760525
0.0001	6.838265