CREB5.H12INVITRO.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB5.H12INVITRO.1.SM.B
Gene (human)	CREB5 (GeneCards)
Gene synonyms (human)	CREBPA
Gene (mouse)	Creb5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	14
Consensus	nbdATGACGTCAYn
GC content	44.61%
Information content (bits; total / per base)	16.653 / 1.189
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9903

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.742	0.793	0.672	0.735	0.691	0.757	2.328	2.682	148.97	223.409

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.985	0.976	0.966	0.953	0.904	0.893
Overall, 6 experiments	best	1.0	0.999	1.0	0.999	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.998	0.997	0.997	0.995	0.983	0.98
Methyl HT-SELEX, 2 experiments	best	1.0	0.999	1.0	0.999	0.999	0.999
Non-Methyl HT-SELEX, 4 experiments	median	0.888	0.889	0.78	0.788	0.693	0.706
Non-Methyl HT-SELEX, 4 experiments	best	1.0	0.999	0.999	0.999	0.998	0.998

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.931	0.589	0.875	0.521
batch 2	0.945	0.865	0.853	0.549

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	ATF2 {1.1.1.3} (TFClass)
TFClass ID	TFClass: 1.1.1.3.3
HGNC	HGNC:16844
MGI	MGI:2443973
EntrezGene (human)	GeneID:9586 (SSTAR profile)
EntrezGene (mouse)	GeneID:231991 (SSTAR profile)
UniProt ID (human)	CREB5_HUMAN
UniProt ID (mouse)	CREB5_MOUSE
UniProt AC (human)	Q02930 (TFClass)
UniProt AC (mouse)	Q8K1L0 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 0 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	CREB5.H12INVITRO.1.SM.B.pcm
PWM	CREB5.H12INVITRO.1.SM.B.pwm
PFM	CREB5.H12INVITRO.1.SM.B.pfm
Alignment	CREB5.H12INVITRO.1.SM.B.words.tsv
Threshold to P-value map	CREB5.H12INVITRO.1.SM.B.thr
Motif in other formats
JASPAR format	CREB5.H12INVITRO.1.SM.B_jaspar_format.txt
MEME format	CREB5.H12INVITRO.1.SM.B_meme_format.meme
Transfac format	CREB5.H12INVITRO.1.SM.B_transfac_format.txt
Homer format	CREB5.H12INVITRO.1.SM.B_homer_format_0.001.txt CREB5.H12INVITRO.1.SM.B_homer_format_0.0005.txt CREB5.H12INVITRO.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2804.0	1797.0	3577.0	1725.0
02	1049.5	2771.5	2401.5	3680.5
03	2332.0	804.0	5336.0	1431.0
04	9171.0	30.0	696.0	6.0
05	0.0	0.0	2.0	9901.0
06	0.0	0.0	9505.0	398.0
07	9890.0	0.0	0.0	13.0
08	0.0	8985.0	0.0	918.0
09	636.0	11.0	9256.0	0.0
10	1.0	6.0	0.0	9896.0
11	2895.0	6981.0	19.0	8.0
12	9566.0	26.0	271.0	40.0
13	161.0	3100.0	506.0	6136.0
14	1835.5	2681.5	3085.5	2300.5

PFM

	A	C	G	T
01	0.283	0.181	0.361	0.174
02	0.106	0.28	0.243	0.372
03	0.235	0.081	0.539	0.145
04	0.926	0.003	0.07	0.001
05	0.0	0.0	0.0	1.0
06	0.0	0.0	0.96	0.04
07	0.999	0.0	0.0	0.001
08	0.0	0.907	0.0	0.093
09	0.064	0.001	0.935	0.0
10	0.0	0.001	0.0	0.999
11	0.292	0.705	0.002	0.001
12	0.966	0.003	0.027	0.004
13	0.016	0.313	0.051	0.62
14	0.185	0.271	0.312	0.232

PWM

	A	C	G	T
01	0.124	-0.32	0.368	-0.361
02	-0.857	0.113	-0.03	0.396
03	-0.06	-1.123	0.767	-0.547
04	1.309	-4.34	-1.267	-5.699
05	-6.982	-6.982	-6.357	1.385
06	-6.982	-6.982	1.345	-1.823
07	1.384	-6.982	-6.982	-5.087
08	-6.982	1.288	-6.982	-0.991
09	-1.356	-5.227	1.318	-6.982
10	-6.621	-5.699	-6.982	1.385
11	0.156	1.036	-4.757	-5.483
12	1.351	-4.472	-2.205	-4.07
13	-2.72	0.225	-1.584	0.907
14	-0.299	0.08	0.22	-0.073

Standard thresholds

P-value	Threshold
0.001	-0.67734
0.0005	1.20241
0.0001	4.99351