CREB3.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB3.H12RSNP.0.SM.B
Gene (human)	CREB3 (GeneCards)
Gene synonyms (human)	LZIP
Gene (mouse)	Creb3
Gene synonyms (mouse)	Lzip
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	ndSRTGACGTGRMn
GC content	57.01%
Information content (bits; total / per base)	15.735 / 1.124
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	410

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.886	0.88	0.778	0.777	0.677	0.687
Overall, 4 experiments	best	0.994	0.99	0.981	0.974	0.925	0.913
Methyl HT-SELEX, 1 experiments	median	0.984	0.977	0.911	0.897	0.782	0.782
Methyl HT-SELEX, 1 experiments	best	0.984	0.977	0.911	0.897	0.782	0.782
Non-Methyl HT-SELEX, 3 experiments	median	0.788	0.783	0.646	0.657	0.572	0.592
Non-Methyl HT-SELEX, 3 experiments	best	0.994	0.99	0.981	0.974	0.925	0.913

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.825	0.739	0.843	0.66

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB3-like {1.1.7.2} (TFClass)
TFClass ID	TFClass: 1.1.7.2.1
HGNC	HGNC:2347
MGI	MGI:99946
EntrezGene (human)	GeneID:10488 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	CREB3_HUMAN
UniProt ID (mouse)	CREB3_MOUSE
UniProt AC (human)	O43889 (TFClass)
UniProt AC (mouse)	Q61817 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	CREB3.H12RSNP.0.SM.B.pcm
PWM	CREB3.H12RSNP.0.SM.B.pwm
PFM	CREB3.H12RSNP.0.SM.B.pfm
Alignment	CREB3.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	CREB3.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	CREB3.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	CREB3.H12RSNP.0.SM.B_meme_format.meme
Transfac format	CREB3.H12RSNP.0.SM.B_transfac_format.txt
Homer format	CREB3.H12RSNP.0.SM.B_homer_format_0.001.txt CREB3.H12RSNP.0.SM.B_homer_format_0.0005.txt CREB3.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	79.5	75.5	153.5	101.5
02	105.75	30.75	94.75	178.75
03	57.0	68.0	250.0	35.0
04	188.0	14.0	207.0	1.0
05	0.0	5.0	1.0	404.0
06	0.0	5.0	404.0	1.0
07	410.0	0.0	0.0	0.0
08	0.0	410.0	0.0	0.0
09	0.0	0.0	410.0	0.0
10	0.0	1.0	0.0	409.0
11	2.0	131.0	277.0	0.0
12	143.0	0.0	246.0	21.0
13	68.25	266.25	15.25	60.25
14	134.75	84.75	122.75	67.75

PFM

	A	C	G	T
01	0.194	0.184	0.374	0.248
02	0.258	0.075	0.231	0.436
03	0.139	0.166	0.61	0.085
04	0.459	0.034	0.505	0.002
05	0.0	0.012	0.002	0.985
06	0.0	0.012	0.985	0.002
07	1.0	0.0	0.0	0.0
08	0.0	1.0	0.0	0.0
09	0.0	0.0	1.0	0.0
10	0.0	0.002	0.0	0.998
11	0.005	0.32	0.676	0.0
12	0.349	0.0	0.6	0.051
13	0.166	0.649	0.037	0.147
14	0.329	0.207	0.299	0.165

PWM

	A	C	G	T
01	-0.25	-0.301	0.399	-0.01
02	0.031	-1.171	-0.077	0.55
03	-0.575	-0.403	0.883	-1.047
04	0.6	-1.903	0.696	-3.727
05	-4.236	-2.772	-3.727	1.361
06	-4.236	-2.772	1.361	-3.727
07	1.375	-4.236	-4.236	-4.236
08	-4.236	1.375	-4.236	-4.236
09	-4.236	-4.236	1.375	-4.236
10	-4.236	-3.727	-4.236	1.373
11	-3.391	0.242	0.985	-4.236
12	0.329	-4.236	0.867	-1.531
13	-0.399	0.946	-1.826	-0.521
14	0.27	-0.187	0.178	-0.407

Standard thresholds

P-value	Threshold
0.001	1.84571
0.0005	3.43951
0.0001	6.11506