CREB3.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB3.H12INVITRO.0.SM.B
Gene (human)	CREB3 (GeneCards)
Gene synonyms (human)	LZIP
Gene (mouse)	Creb3
Gene synonyms (mouse)	Lzip
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	vRTGACGTSRMn
GC content	57.81%
Information content (bits; total / per base)	14.59 / 1.216
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	6991

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.901	0.896	0.781	0.783	0.681	0.692
Overall, 4 experiments	best	0.995	0.992	0.985	0.979	0.937	0.927
Methyl HT-SELEX, 1 experiments	median	0.986	0.98	0.906	0.893	0.786	0.784
Methyl HT-SELEX, 1 experiments	best	0.986	0.98	0.906	0.893	0.786	0.784
Non-Methyl HT-SELEX, 3 experiments	median	0.816	0.812	0.657	0.673	0.576	0.6
Non-Methyl HT-SELEX, 3 experiments	best	0.995	0.992	0.985	0.979	0.937	0.927

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.819	0.718	0.809	0.641

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB3-like {1.1.7.2} (TFClass)
TFClass ID	TFClass: 1.1.7.2.1
HGNC	HGNC:2347
MGI	MGI:99946
EntrezGene (human)	GeneID:10488 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	CREB3_HUMAN
UniProt ID (mouse)	CREB3_MOUSE
UniProt AC (human)	O43889 (TFClass)
UniProt AC (mouse)	Q61817 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	CREB3.H12INVITRO.0.SM.B.pcm
PWM	CREB3.H12INVITRO.0.SM.B.pwm
PFM	CREB3.H12INVITRO.0.SM.B.pfm
Alignment	CREB3.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	CREB3.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	CREB3.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	CREB3.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	CREB3.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	CREB3.H12INVITRO.0.SM.B_homer_format_0.001.txt CREB3.H12INVITRO.0.SM.B_homer_format_0.0005.txt CREB3.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1100.0	1148.0	3708.0	1035.0
02	3072.25	364.25	3400.25	154.25
03	13.0	89.0	52.0	6837.0
04	5.0	71.0	6877.0	38.0
05	6991.0	0.0	0.0	0.0
06	0.0	6991.0	0.0	0.0
07	0.0	0.0	6991.0	0.0
08	0.0	2.0	0.0	6989.0
09	159.0	1688.0	5094.0	50.0
10	1809.0	84.0	4038.0	1060.0
11	1577.0	4062.0	486.0	866.0
12	2511.0	1520.0	1830.0	1130.0

PFM

	A	C	G	T
01	0.157	0.164	0.53	0.148
02	0.439	0.052	0.486	0.022
03	0.002	0.013	0.007	0.978
04	0.001	0.01	0.984	0.005
05	1.0	0.0	0.0	0.0
06	0.0	1.0	0.0	0.0
07	0.0	0.0	1.0	0.0
08	0.0	0.0	0.0	1.0
09	0.023	0.241	0.729	0.007
10	0.259	0.012	0.578	0.152
11	0.226	0.581	0.07	0.124
12	0.359	0.217	0.262	0.162

PWM

	A	C	G	T
01	-0.462	-0.42	0.751	-0.523
02	0.564	-1.563	0.665	-2.415
03	-4.745	-2.954	-3.474	1.363
04	-5.491	-3.174	1.369	-3.773
05	1.385	-6.673	-6.673	-6.673
06	-6.673	1.385	-6.673	-6.673
07	-6.673	-6.673	1.385	-6.673
08	-6.673	-6.029	-6.673	1.385
09	-2.385	-0.035	1.069	-3.512
10	0.034	-3.011	0.837	-0.499
11	-0.103	0.843	-1.277	-0.701
12	0.362	-0.139	0.046	-0.435

Standard thresholds

P-value	Threshold
0.001	1.208315
0.0005	2.791405
0.0001	6.31814