CREB1.H12INVITRO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CREB1.H12INVITRO.0.PSM.A
Gene (human)	CREB1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Creb1
Gene synonyms (mouse)	Creb-1
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	11
Consensus	nRTGACGTvRb
GC content	51.3%
Information content (bits; total / per base)	12.857 / 1.169
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	6654

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	26 (166)	0.888	0.973	0.836	0.953	0.866	0.956	3.861	6.402	340.883	779.056
Mouse	25 (157)	0.892	0.965	0.834	0.944	0.874	0.95	3.928	4.96	206.658	532.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.983	0.972	0.967	0.952	0.906	0.891
Overall, 4 experiments	best	0.996	0.994	0.988	0.983	0.959	0.95
Methyl HT-SELEX, 2 experiments	median	0.972	0.959	0.925	0.906	0.817	0.809
Methyl HT-SELEX, 2 experiments	best	0.977	0.965	0.956	0.937	0.868	0.854
Non-Methyl HT-SELEX, 2 experiments	median	0.992	0.986	0.984	0.975	0.952	0.94
Non-Methyl HT-SELEX, 2 experiments	best	0.996	0.994	0.988	0.983	0.959	0.95

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	11.403	64.817	0.417	0.311

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.949	0.614	0.894	0.531
batch 2	0.794	0.62	0.805	0.607

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	CREB-related {1.1.7} (TFClass)
TF subfamily	CREB-like {1.1.7.1} (TFClass)
TFClass ID	TFClass: 1.1.7.1.1
HGNC	HGNC:2345
MGI	MGI:88494
EntrezGene (human)	GeneID:1385 (SSTAR profile)
EntrezGene (mouse)	GeneID:12912 (SSTAR profile)
UniProt ID (human)	CREB1_HUMAN
UniProt ID (mouse)	CREB1_MOUSE
UniProt AC (human)	P16220 (TFClass)
UniProt AC (mouse)	Q01147 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	26 human, 25 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	CREB1.H12INVITRO.0.PSM.A.pcm
PWM	CREB1.H12INVITRO.0.PSM.A.pwm
PFM	CREB1.H12INVITRO.0.PSM.A.pfm
Alignment	CREB1.H12INVITRO.0.PSM.A.words.tsv
Threshold to P-value map	CREB1.H12INVITRO.0.PSM.A.thr
Motif in other formats
JASPAR format	CREB1.H12INVITRO.0.PSM.A_jaspar_format.txt
MEME format	CREB1.H12INVITRO.0.PSM.A_meme_format.meme
Transfac format	CREB1.H12INVITRO.0.PSM.A_transfac_format.txt
Homer format	CREB1.H12INVITRO.0.PSM.A_homer_format_0.001.txt CREB1.H12INVITRO.0.PSM.A_homer_format_0.0005.txt CREB1.H12INVITRO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1240.75	1529.75	2571.75	1311.75
02	3964.25	85.25	2542.25	62.25
03	0.0	0.0	106.0	6548.0
04	0.0	0.0	6654.0	0.0
05	6654.0	0.0	0.0	0.0
06	0.0	6197.0	49.0	408.0
07	20.0	0.0	6633.0	1.0
08	51.0	735.0	123.0	5745.0
09	1830.0	3463.0	1029.0	332.0
10	4597.0	444.0	1024.0	589.0
11	747.75	2754.75	1608.75	1542.75

PFM

	A	C	G	T
01	0.186	0.23	0.386	0.197
02	0.596	0.013	0.382	0.009
03	0.0	0.0	0.016	0.984
04	0.0	0.0	1.0	0.0
05	1.0	0.0	0.0	0.0
06	0.0	0.931	0.007	0.061
07	0.003	0.0	0.997	0.0
08	0.008	0.11	0.018	0.863
09	0.275	0.52	0.155	0.05
10	0.691	0.067	0.154	0.089
11	0.112	0.414	0.242	0.232

PWM

	A	C	G	T
01	-0.293	-0.084	0.435	-0.237
02	0.868	-2.947	0.424	-3.252
03	-6.629	-6.629	-2.734	1.369
04	-6.629	-6.629	1.385	-6.629
05	1.385	-6.629	-6.629	-6.629
06	-6.629	1.314	-3.482	-1.401
07	-4.318	-6.629	1.382	-6.255
08	-3.444	-0.815	-2.588	1.238
09	0.095	0.733	-0.48	-1.606
10	1.016	-1.317	-0.484	-1.036
11	-0.798	0.504	-0.033	-0.075

Standard thresholds

P-value	Threshold
0.001	2.94699
0.0005	4.46635
0.0001	7.35284