MotifCREB1.H12CORE.0.PSM.A
Gene (human)CREB1
(GeneCards)
Gene synonyms (human)
Gene (mouse)Creb1
Gene synonyms (mouse)Creb-1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length11
ConsensusnRTGACGTMRb
GC content50.79%
Information content (bits; total / per base)14.179 / 1.289
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words5716

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 26 (166) 0.848 0.897 0.809 0.899 0.86 0.908 3.8 5.717 306.011 796.824
Mouse 25 (157) 0.843 0.929 0.811 0.91 0.869 0.949 3.88 4.82 199.409 521.959

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.98 0.97 0.966 0.948 0.905 0.889
best 0.996 0.994 0.99 0.985 0.963 0.955
Methyl HT-SELEX, 2 experiments median 0.965 0.952 0.92 0.898 0.816 0.804
best 0.972 0.96 0.95 0.927 0.861 0.844
Non-Methyl HT-SELEX, 2 experiments median 0.992 0.987 0.986 0.977 0.956 0.945
best 0.996 0.994 0.99 0.985 0.963 0.955

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 12.64 67.988 0.462 0.34

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.984 0.872 0.956 0.604
batch 2 0.805 0.687 0.818 0.584
TF superclassBasic domains {1} (TFClass)
TF classBasic leucine zipper factors (bZIP) {1.1} (TFClass)
TF familyCREB-related {1.1.7} (TFClass)
TF subfamilyCREB-like {1.1.7.1} (TFClass)
TFClass IDTFClass: 1.1.7.1.1
HGNCHGNC:2345
MGIMGI:88494
EntrezGene (human)GeneID:1385
(SSTAR profile)
EntrezGene (mouse)GeneID:12912
(SSTAR profile)
UniProt ID (human)CREB1_HUMAN
UniProt ID (mouse)CREB1_MOUSE
UniProt AC (human)P16220
(TFClass)
UniProt AC (mouse)Q01147
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 26 human, 25 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
011179.01876.01706.0955.0
022980.060.02676.00.0
030.00.00.05716.0
040.00.05716.00.0
055716.00.00.00.0
060.05716.00.00.0
070.00.05716.00.0
080.032.00.05684.0
092635.02463.0516.0102.0
103730.25325.251145.25515.25
11807.252135.251852.25921.25
PFM
ACGT
010.2060.3280.2980.167
020.5210.010.4680.0
030.00.00.01.0
040.00.01.00.0
051.00.00.00.0
060.01.00.00.0
070.00.01.00.0
080.00.0060.00.994
090.4610.4310.090.018
100.6530.0570.20.09
110.1410.3740.3240.161
PWM
ACGT
01-0.1920.2720.177-0.402
020.734-3.1360.627-6.495
03-6.495-6.495-6.4951.385
04-6.495-6.4951.385-6.495
051.385-6.495-6.495-6.495
06-6.4951.385-6.495-6.495
07-6.495-6.4951.385-6.495
08-6.495-3.735-6.4951.38
090.6110.544-1.016-2.62
100.959-1.475-0.221-1.017
11-0.570.4010.259-0.438
Standard thresholds
P-value Threshold
0.001 0.74402
0.0005 2.026735
0.0001 6.392685