MotifCOT1.H12INVITRO.1.PSM.A
Gene (human)NR2F1
(GeneCards)
Gene synonyms (human)EAR3, ERBAL3, TFCOUP1
Gene (mouse)Nr2f1
Gene synonyms (mouse)Erbal3, Tfcoup1
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
A
Motif length16
ConsensusdRGKYCAAAGGTCAnn
GC content49.79%
Information content (bits; total / per base)18.652 / 1.166
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words1551

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 5 (34) 0.858 0.895 0.767 0.836 0.821 0.86 2.929 3.683 139.58 214.215

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.999 0.998 0.974 0.971 0.93 0.92
best 1.0 1.0 1.0 1.0 0.989 0.987
Methyl HT-SELEX, 2 experiments median 1.0 1.0 0.998 0.997 0.977 0.974
best 1.0 1.0 0.999 0.999 0.979 0.975
Non-Methyl HT-SELEX, 6 experiments median 0.995 0.994 0.952 0.944 0.886 0.861
best 1.0 1.0 1.0 1.0 0.989 0.987

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.769 6.801 0.152 0.097
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyRXR-related receptors {2.1.3} (TFClass)
TF subfamilyCOUP (NR2F) {2.1.3.5} (TFClass)
TFClass IDTFClass: 2.1.3.5.1
HGNCHGNC:7975
MGIMGI:1352451
EntrezGene (human)GeneID:7025
(SSTAR profile)
EntrezGene (mouse)GeneID:13865
(SSTAR profile)
UniProt ID (human)COT1_HUMAN
UniProt ID (mouse)COT1_MOUSE
UniProt AC (human)P10589
(TFClass)
UniProt AC (mouse)Q60632
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 5 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
01532.0190.0614.0215.0
02612.2563.25812.2563.25
0345.059.01359.088.0
0444.073.01109.0325.0
0549.0343.050.01109.0
06310.01175.025.041.0
071450.035.018.048.0
081318.012.0144.077.0
091477.00.073.01.0
100.00.01549.02.0
110.00.01551.00.0
120.01.04.01546.0
130.01501.017.033.0
141437.07.0100.07.0
15571.75369.75212.75396.75
16387.75310.75578.75273.75
PFM
ACGT
010.3430.1230.3960.139
020.3950.0410.5240.041
030.0290.0380.8760.057
040.0280.0470.7150.21
050.0320.2210.0320.715
060.20.7580.0160.026
070.9350.0230.0120.031
080.850.0080.0930.05
090.9520.00.0470.001
100.00.00.9990.001
110.00.01.00.0
120.00.0010.0030.997
130.00.9680.0110.021
140.9260.0050.0640.005
150.3690.2380.1370.256
160.250.20.3730.176
PWM
ACGT
010.315-0.7080.458-0.586
020.455-1.7890.737-1.789
03-2.118-1.8571.251-1.467
04-2.14-1.651.048-0.176
05-2.036-0.122-2.0171.048
06-0.2231.105-2.675-2.208
071.315-2.359-2.978-2.056
081.22-3.338-0.983-1.598
091.334-5.357-1.65-4.922
10-5.357-5.3571.381-4.62
11-5.357-5.3571.383-5.357
12-5.357-4.922-4.2011.38
13-5.3571.35-3.029-2.414
141.307-3.786-1.342-3.786
150.387-0.047-0.5960.023
160.0-0.220.399-0.346
Standard thresholds
P-value Threshold
0.001 0.22731
0.0005 1.76991
0.0001 4.97871