MotifCOT1.H12CORE.0.PSM.A
Gene (human)NR2F1
(GeneCards)
Gene synonyms (human)EAR3, ERBAL3, TFCOUP1
Gene (mouse)Nr2f1
Gene synonyms (mouse)Erbal3, Tfcoup1
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length10
ConsensusndRGGTCAnn
GC content52.95%
Information content (bits; total / per base)9.29 / 0.929
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9822

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 5 (34) 0.873 0.915 0.763 0.84 0.837 0.893 2.624 3.115 177.361 321.102

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 8 experiments median 0.997 0.995 0.987 0.983 0.959 0.95
best 1.0 1.0 0.998 0.998 0.991 0.988
Methyl HT-SELEX, 2 experiments median 0.997 0.996 0.993 0.99 0.98 0.974
best 0.999 0.998 0.995 0.993 0.982 0.974
Non-Methyl HT-SELEX, 6 experiments median 0.997 0.995 0.976 0.971 0.934 0.915
best 1.0 1.0 0.998 0.998 0.991 0.988

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 2.506 5.744 0.185 0.103
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyRXR-related receptors {2.1.3} (TFClass)
TF subfamilyCOUP (NR2F) {2.1.3.5} (TFClass)
TFClass IDTFClass: 2.1.3.5.1
HGNCHGNC:7975
MGIMGI:1352451
EntrezGene (human)GeneID:7025
(SSTAR profile)
EntrezGene (mouse)GeneID:13865
(SSTAR profile)
UniProt ID (human)COT1_HUMAN
UniProt ID (mouse)COT1_MOUSE
UniProt AC (human)P10589
(TFClass)
UniProt AC (mouse)Q60632
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 5 human, 0 mouse
HT-SELEX 6
Methyl-HT-SELEX 2
PCM
ACGT
013255.51973.52112.52480.5
023663.01028.03731.01400.0
035771.0316.03264.0471.0
045.089.09618.0110.0
050.014.09776.032.0
0617.010.087.09708.0
07158.08995.0371.0298.0
088306.0324.0956.0236.0
093365.752386.751828.752240.75
102976.251777.253351.251717.25
PFM
ACGT
010.3310.2010.2150.253
020.3730.1050.380.143
030.5880.0320.3320.048
040.0010.0090.9790.011
050.00.0010.9950.003
060.0020.0010.0090.988
070.0160.9160.0380.03
080.8460.0330.0970.024
090.3430.2430.1860.228
100.3030.1810.3410.175
PWM
ACGT
010.282-0.218-0.150.01
020.4-0.8690.418-0.561
030.854-2.0440.284-1.647
04-5.819-3.2931.365-3.086
05-6.975-5.0161.381-4.272
06-4.847-5.298-3.3151.374
07-2.731.298-1.885-2.102
081.218-2.019-0.942-2.333
090.315-0.028-0.294-0.091
100.192-0.3230.311-0.357
Standard thresholds
P-value Threshold
0.001 4.8738
0.0005 5.871465
0.0001 7.67062