MotifCLOCK.H12RSNP.0.M.C
Gene (human)CLOCK
(GeneCards)
Gene synonyms (human)BHLHE8, KIAA0334
Gene (mouse)Clock
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
C
Motif length13
ConsensusnnRCACATGTbhn
GC content45.24%
Information content (bits; total / per base)13.025 / 1.002
Data sourcesMethyl-HT-SELEX
Aligned words2434

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (17) 0.736 0.774 0.533 0.574 0.587 0.666 1.318 1.738 4.824 38.699
Mouse 10 (66) 0.754 0.816 0.554 0.61 0.662 0.689 1.62 1.767 33.427 57.854

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.853 0.826 0.808 0.79 0.781 0.768
best 0.994 0.99 0.99 0.984 0.977 0.967
Methyl HT-SELEX, 1 experiments median 0.994 0.99 0.99 0.984 0.977 0.967
best 0.994 0.99 0.99 0.984 0.977 0.967
Non-Methyl HT-SELEX, 3 experiments median 0.725 0.688 0.636 0.618 0.585 0.578
best 0.981 0.965 0.98 0.962 0.977 0.958

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 0.865 0.078 0.017 0.004

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 1 0.855 0.528 0.477 0.286
batch 2 0.818 0.61 0.376 0.259
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyPAS {1.2.5} (TFClass)
TF subfamilyPAS-ARNT {1.2.5.2} (TFClass)
TFClass IDTFClass: 1.2.5.2.5
HGNCHGNC:2082
MGIMGI:99698
EntrezGene (human)GeneID:9575
(SSTAR profile)
EntrezGene (mouse)GeneID:12753
(SSTAR profile)
UniProt ID (human)CLOCK_HUMAN
UniProt ID (mouse)CLOCK_MOUSE
UniProt AC (human)O15516
(TFClass)
UniProt AC (mouse)O08785
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 10 mouse
HT-SELEX 3
Methyl-HT-SELEX 1
PCM
ACGT
01835.5391.5549.5657.5
02847.75435.75630.75519.75
031637.0309.0454.034.0
0445.02379.04.06.0
051570.02.0862.00.0
060.02421.00.013.0
072305.00.0129.00.0
080.00.00.02434.0
091.00.02433.00.0
105.0297.073.02059.0
11217.0462.0384.01371.0
12563.25629.25310.25931.25
13621.5609.5550.5652.5
PFM
ACGT
010.3430.1610.2260.27
020.3480.1790.2590.214
030.6730.1270.1870.014
040.0180.9770.0020.002
050.6450.0010.3540.0
060.00.9950.00.005
070.9470.00.0530.0
080.00.00.01.0
090.00.01.00.0
100.0020.1220.030.846
110.0890.190.1580.563
120.2310.2590.1270.383
130.2550.250.2260.268
PWM
ACGT
010.316-0.439-0.1020.077
020.331-0.3330.036-0.157
030.988-0.675-0.292-2.832
04-2.5651.361-4.631-4.341
050.946-5.0410.347-5.747
06-5.7471.379-5.747-3.71
071.329-5.747-1.539-5.747
08-5.747-5.747-5.7471.384
09-5.333-5.7471.383-5.747
10-4.476-0.714-2.0971.217
11-1.025-0.274-0.4580.811
12-0.0770.033-0.6710.424
130.0210.002-0.10.07
Standard thresholds
P-value Threshold
0.001 2.77816
0.0005 4.23016
0.0001 7.358275