CEBPB.H12RSNP.1.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CEBPB.H12RSNP.1.SM.B
Gene (human)	CEBPB (GeneCards)
Gene synonyms (human)	TCF5
Gene (mouse)	Cebpb
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	15
Consensus	nvTTGCGCAATMnnn
GC content	43.03%
Information content (bits; total / per base)	17.099 / 1.14
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9969

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	74 (475)	0.932	0.974	0.873	0.969	0.88	0.955	3.322	6.086	407.678	823.387
Mouse	112 (694)	0.946	0.979	0.902	0.971	0.861	0.943	3.182	4.932	390.682	825.319

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.998	0.996	0.995	0.992	0.967	0.962
Overall, 10 experiments	best	1.0	1.0	1.0	0.999	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.996	0.994	0.992	0.987	0.971	0.963
Methyl HT-SELEX, 2 experiments	best	0.997	0.994	0.992	0.989	0.977	0.968
Non-Methyl HT-SELEX, 8 experiments	median	0.999	0.998	0.997	0.995	0.967	0.961
Non-Methyl HT-SELEX, 8 experiments	best	1.0	1.0	1.0	0.999	0.999	0.999

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	19.983	205.284	0.462	0.437

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.951	0.861	0.937	0.637
batch 2	0.729	0.236	0.709	0.456

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	C/EBP-related {1.1.8} (TFClass)
TF subfamily	CEBP {1.1.8.1} (TFClass)
TFClass ID	TFClass: 1.1.8.1.2
HGNC	HGNC:1834
MGI	MGI:88373
EntrezGene (human)	GeneID:1051 (SSTAR profile)
EntrezGene (mouse)	GeneID:12608 (SSTAR profile)
UniProt ID (human)	CEBPB_HUMAN
UniProt ID (mouse)	CEBPB_MOUSE
UniProt AC (human)	P17676 (TFClass)
UniProt AC (mouse)	P28033 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	74 human, 112 mouse
HT-SELEX	8
Methyl-HT-SELEX	2

PCM	CEBPB.H12RSNP.1.SM.B.pcm
PWM	CEBPB.H12RSNP.1.SM.B.pwm
PFM	CEBPB.H12RSNP.1.SM.B.pfm
Alignment	CEBPB.H12RSNP.1.SM.B.words.tsv
Threshold to P-value map	CEBPB.H12RSNP.1.SM.B.thr
Motif in other formats
JASPAR format	CEBPB.H12RSNP.1.SM.B_jaspar_format.txt
MEME format	CEBPB.H12RSNP.1.SM.B_meme_format.meme
Transfac format	CEBPB.H12RSNP.1.SM.B_transfac_format.txt
Homer format	CEBPB.H12RSNP.1.SM.B_homer_format_0.001.txt CEBPB.H12RSNP.1.SM.B_homer_format_0.0005.txt CEBPB.H12RSNP.1.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2483.75	1746.75	1949.75	3788.75
02	5100.75	1209.75	3069.75	588.75
03	15.0	8.0	1.0	9945.0
04	5.0	2.0	55.0	9907.0
05	2063.0	9.0	7709.0	188.0
06	6.0	9925.0	4.0	34.0
07	16.0	6.0	9946.0	1.0
08	9.0	9283.0	0.0	677.0
09	9966.0	1.0	2.0	0.0
10	9964.0	3.0	2.0	0.0
11	3.0	1069.0	152.0	8745.0
12	4628.0	4472.0	228.0	641.0
13	2640.0	2584.0	2331.0	2414.0
14	1959.5	2583.5	1870.5	3555.5
15	2416.5	2162.5	1960.5	3429.5

PFM

	A	C	G	T
01	0.249	0.175	0.196	0.38
02	0.512	0.121	0.308	0.059
03	0.002	0.001	0.0	0.998
04	0.001	0.0	0.006	0.994
05	0.207	0.001	0.773	0.019
06	0.001	0.996	0.0	0.003
07	0.002	0.001	0.998	0.0
08	0.001	0.931	0.0	0.068
09	1.0	0.0	0.0	0.0
10	0.999	0.0	0.0	0.0
11	0.0	0.107	0.015	0.877
12	0.464	0.449	0.023	0.064
13	0.265	0.259	0.234	0.242
14	0.197	0.259	0.188	0.357
15	0.242	0.217	0.197	0.344

PWM

	A	C	G	T
01	-0.003	-0.355	-0.245	0.419
02	0.716	-0.722	0.208	-1.44
03	-4.971	-5.49	-6.627	1.383
04	-5.834	-6.363	-3.774	1.379
05	-0.189	-5.397	1.129	-2.573
06	-5.705	1.381	-5.981	-4.23
07	-4.915	-5.705	1.383	-6.627
08	-5.397	1.314	-6.988	-1.301
09	1.385	-6.627	-6.363	-6.988
10	1.385	-6.154	-6.363	-6.988
11	-6.154	-0.845	-2.783	1.255
12	0.619	0.584	-2.382	-1.355
13	0.058	0.036	-0.067	-0.032
14	-0.24	0.036	-0.287	0.355
15	-0.031	-0.142	-0.24	0.319

Standard thresholds

P-value	Threshold
0.001	-1.56789
0.0005	0.46206
0.0001	4.34056