CEBPB.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	CEBPB.H12RSNP.0.P.B
Gene (human)	CEBPB (GeneCards)
Gene synonyms (human)	TCF5
Gene (mouse)	Cebpb
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	dRTTRYGCAAYv
GC content	40.4%
Information content (bits; total / per base)	12.655 / 1.055
Data sources	ChIP-Seq
Aligned words	970

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	74 (475)	0.949	0.987	0.892	0.962	0.929	0.982	3.782	5.355	505.854	1058.495
Mouse	112 (694)	0.963	0.99	0.922	0.979	0.918	0.964	3.578	5.314	502.057	994.26

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.997	0.995	0.995	0.991	0.974	0.965
Overall, 10 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999
Methyl HT-SELEX, 2 experiments	median	0.995	0.992	0.991	0.986	0.973	0.965
Methyl HT-SELEX, 2 experiments	best	0.996	0.993	0.993	0.988	0.977	0.967
Non-Methyl HT-SELEX, 8 experiments	median	0.998	0.997	0.997	0.995	0.975	0.97
Non-Methyl HT-SELEX, 8 experiments	best	1.0	1.0	1.0	1.0	0.999	0.999

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	23.67	219.174	0.385	0.407

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.918	0.818	0.941	0.674
batch 2	0.763	0.244	0.736	0.473

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	C/EBP-related {1.1.8} (TFClass)
TF subfamily	CEBP {1.1.8.1} (TFClass)
TFClass ID	TFClass: 1.1.8.1.2
HGNC	HGNC:1834
MGI	MGI:88373
EntrezGene (human)	GeneID:1051 (SSTAR profile)
EntrezGene (mouse)	GeneID:12608 (SSTAR profile)
UniProt ID (human)	CEBPB_HUMAN
UniProt ID (mouse)	CEBPB_MOUSE
UniProt AC (human)	P17676 (TFClass)
UniProt AC (mouse)	P28033 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	74 human, 112 mouse
HT-SELEX	8
Methyl-HT-SELEX	2

PCM	CEBPB.H12RSNP.0.P.B.pcm
PWM	CEBPB.H12RSNP.0.P.B.pwm
PFM	CEBPB.H12RSNP.0.P.B.pfm
Alignment	CEBPB.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	CEBPB.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	CEBPB.H12RSNP.0.P.B_jaspar_format.txt
MEME format	CEBPB.H12RSNP.0.P.B_meme_format.meme
Transfac format	CEBPB.H12RSNP.0.P.B_transfac_format.txt
Homer format	CEBPB.H12RSNP.0.P.B_homer_format_0.001.txt CEBPB.H12RSNP.0.P.B_homer_format_0.0005.txt CEBPB.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	182.0	96.0	287.0	405.0
02	505.0	114.0	336.0	15.0
03	7.0	15.0	13.0	935.0
04	6.0	9.0	264.0	691.0
05	379.0	7.0	464.0	120.0
06	16.0	577.0	23.0	354.0
07	31.0	10.0	916.0	13.0
08	45.0	862.0	6.0	57.0
09	949.0	17.0	2.0	2.0
10	931.0	11.0	24.0	4.0
11	14.0	127.0	70.0	759.0
12	490.0	273.0	179.0	28.0

PFM

	A	C	G	T
01	0.188	0.099	0.296	0.418
02	0.521	0.118	0.346	0.015
03	0.007	0.015	0.013	0.964
04	0.006	0.009	0.272	0.712
05	0.391	0.007	0.478	0.124
06	0.016	0.595	0.024	0.365
07	0.032	0.01	0.944	0.013
08	0.046	0.889	0.006	0.059
09	0.978	0.018	0.002	0.002
10	0.96	0.011	0.025	0.004
11	0.014	0.131	0.072	0.782
12	0.505	0.281	0.185	0.029

PWM

	A	C	G	T
01	-0.285	-0.916	0.167	0.51
02	0.73	-0.747	0.324	-2.682
03	-3.333	-2.682	-2.809	1.344
04	-3.454	-3.126	0.084	1.043
05	0.444	-3.333	0.646	-0.696
06	-2.623	0.863	-2.29	0.376
07	-2.01	-3.037	1.324	-2.809
08	-1.654	1.263	-3.454	-1.425
09	1.359	-2.569	-4.185	-4.185
10	1.34	-2.955	-2.251	-3.754
11	-2.743	-0.64	-1.225	1.136
12	0.7	0.118	-0.301	-2.106

Standard thresholds

P-value	Threshold
0.001	3.82621
0.0005	4.908315
0.0001	7.099365