BHE41.H12INVIVO.0.PSM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	BHE41.H12INVIVO.0.PSM.A
Gene (human)	BHLHE41 (GeneCards)
Gene synonyms (human)	BHLHB3, DEC2, SHARP1
Gene (mouse)	Bhlhe41
Gene synonyms (mouse)	Bhlhb3, Dec2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	19
Consensus	bnbvvvvdCRCGTGCvvvv
GC content	68.14%
Information content (bits; total / per base)	12.95 / 0.682
Data sources	ChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words	991

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	2 (14)	0.949	0.965	0.909	0.928	0.9	0.918	3.738	3.82	472.929	561.77

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.994	0.99	0.894	0.902	0.705	0.748
Overall, 6 experiments	best	0.998	0.996	0.998	0.996	0.997	0.995
Methyl HT-SELEX, 1 experiments	median	0.997	0.993	0.995	0.992	0.98	0.975
Methyl HT-SELEX, 1 experiments	best	0.997	0.993	0.995	0.992	0.98	0.975
Non-Methyl HT-SELEX, 5 experiments	median	0.991	0.987	0.833	0.847	0.664	0.707
Non-Methyl HT-SELEX, 5 experiments	best	0.998	0.996	0.998	0.996	0.997	0.995

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Hairy-related {1.2.4} (TFClass)
TF subfamily	HAIRY {1.2.4.1} (TFClass)
TFClass ID	TFClass: 1.2.4.1.13
HGNC	HGNC:16617
MGI	MGI:1930704
EntrezGene (human)	GeneID:79365 (SSTAR profile)
EntrezGene (mouse)	GeneID:79362 (SSTAR profile)
UniProt ID (human)	BHE41_HUMAN
UniProt ID (mouse)	BHE41_MOUSE
UniProt AC (human)	Q9C0J9 (TFClass)
UniProt AC (mouse)	Q99PV5 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	1

PCM	BHE41.H12INVIVO.0.PSM.A.pcm
PWM	BHE41.H12INVIVO.0.PSM.A.pwm
PFM	BHE41.H12INVIVO.0.PSM.A.pfm
Alignment	BHE41.H12INVIVO.0.PSM.A.words.tsv
Threshold to P-value map	BHE41.H12INVIVO.0.PSM.A.thr
Motif in other formats
JASPAR format	BHE41.H12INVIVO.0.PSM.A_jaspar_format.txt
MEME format	BHE41.H12INVIVO.0.PSM.A_meme_format.meme
Transfac format	BHE41.H12INVIVO.0.PSM.A_transfac_format.txt
Homer format	BHE41.H12INVIVO.0.PSM.A_homer_format_0.001.txt BHE41.H12INVIVO.0.PSM.A_homer_format_0.0005.txt BHE41.H12INVIVO.0.PSM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	140.0	342.0	367.0	142.0
02	210.0	283.0	329.0	169.0
03	108.0	413.0	328.0	142.0
04	205.0	325.0	328.0	133.0
05	160.0	390.0	340.0	101.0
06	235.0	225.0	389.0	142.0
07	190.0	268.0	486.0	47.0
08	162.0	21.0	379.0	429.0
09	103.0	881.0	6.0	1.0
10	669.0	88.0	160.0	74.0
11	0.0	979.0	4.0	8.0
12	2.0	7.0	982.0	0.0
13	5.0	0.0	0.0	986.0
14	0.0	2.0	981.0	8.0
15	245.0	737.0	4.0	5.0
16	228.0	331.0	321.0	111.0
17	144.0	362.0	409.0	76.0
18	238.0	325.0	331.0	97.0
19	183.0	306.0	401.0	101.0

PFM

	A	C	G	T
01	0.141	0.345	0.37	0.143
02	0.212	0.286	0.332	0.171
03	0.109	0.417	0.331	0.143
04	0.207	0.328	0.331	0.134
05	0.161	0.394	0.343	0.102
06	0.237	0.227	0.393	0.143
07	0.192	0.27	0.49	0.047
08	0.163	0.021	0.382	0.433
09	0.104	0.889	0.006	0.001
10	0.675	0.089	0.161	0.075
11	0.0	0.988	0.004	0.008
12	0.002	0.007	0.991	0.0
13	0.005	0.0	0.0	0.995
14	0.0	0.002	0.99	0.008
15	0.247	0.744	0.004	0.005
16	0.23	0.334	0.324	0.112
17	0.145	0.365	0.413	0.077
18	0.24	0.328	0.334	0.098
19	0.185	0.309	0.405	0.102

PWM

	A	C	G	T
01	-0.565	0.32	0.391	-0.551
02	-0.164	0.132	0.282	-0.379
03	-0.821	0.508	0.279	-0.551
04	-0.188	0.27	0.279	-0.616
05	-0.433	0.451	0.315	-0.887
06	-0.052	-0.096	0.449	-0.551
07	-0.263	0.078	0.67	-1.633
08	-0.421	-2.396	0.423	0.546
09	-0.868	1.264	-3.475	-4.517
10	0.989	-1.023	-0.433	-1.192
11	-4.974	1.369	-3.775	-3.245
12	-4.204	-3.353	1.372	-4.974
13	-3.614	-4.974	-4.974	1.376
14	-4.974	-4.204	1.371	-3.245
15	-0.011	1.086	-3.775	-3.614
16	-0.082	0.288	0.257	-0.794
17	-0.538	0.377	0.499	-1.166
18	-0.04	0.27	0.288	-0.927
19	-0.3	0.21	0.479	-0.887

Standard thresholds

P-value	Threshold
0.001	3.47316
0.0005	4.70776
0.0001	7.27426