MotifBHE40.H12INVITRO.1.S.C
Gene (human)BHLHE40
(GeneCards)
Gene synonyms (human)BHLHB2, DEC1, SHARP2, STRA13
Gene (mouse)Bhlhe40
Gene synonyms (mouse)Bhlhb2, Clast5, Dec1, Stra13
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
C
Motif length22
ConsensusnnSMMSKKnnnvKCACGTGMnn
GC content58.72%
Information content (bits; total / per base)17.51 / 0.796
Data sourcesHT-SELEX
Aligned words1866

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 5 (35) 0.768 0.833 0.742 0.815 0.838 0.893 3.216 3.697 278.495 402.921
Mouse 7 (43) 0.768 0.877 0.732 0.866 0.822 0.919 3.13 4.088 239.77 423.721

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 10 experiments median 0.997 0.995 0.977 0.973 0.851 0.862
best 1.0 0.999 0.999 0.998 0.998 0.997
Methyl HT-SELEX, 2 experiments median 0.99 0.983 0.949 0.94 0.814 0.82
best 0.993 0.988 0.957 0.951 0.824 0.83
Non-Methyl HT-SELEX, 8 experiments median 0.998 0.997 0.997 0.995 0.878 0.895
best 1.0 0.999 0.999 0.998 0.998 0.997

rSNP benchmarking, ADASTRA odds-ratio -log-Fisher's P Pearson r Kendall tau
# 15.603 25.022 0.352 0.28
TF superclassBasic domains {1} (TFClass)
TF classBasic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF familyHairy-related {1.2.4} (TFClass)
TF subfamilyHAIRY {1.2.4.1} (TFClass)
TFClass IDTFClass: 1.2.4.1.12
HGNCHGNC:1046
MGIMGI:1097714
EntrezGene (human)GeneID:8553
(SSTAR profile)
EntrezGene (mouse)GeneID:20893
(SSTAR profile)
UniProt ID (human)BHE40_HUMAN
UniProt ID (mouse)BHE40_MOUSE
UniProt AC (human)O14503
(TFClass)
UniProt AC (mouse)O35185
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 5 human, 7 mouse
HT-SELEX 8
Methyl-HT-SELEX 2
PCM
ACGT
01387.25491.25554.25433.25
02384.75270.75645.75564.75
03176.01276.0230.0184.0
041196.0298.0256.0116.0
05294.01281.0139.0152.0
06141.0295.01326.0104.0
07147.0210.0305.01204.0
08136.0117.01274.0339.0
09543.0469.0495.0359.0
10456.0471.0500.0439.0
11479.0349.0659.0379.0
12524.0351.0726.0265.0
1325.013.0916.0912.0
140.01865.01.00.0
151866.00.00.00.0
160.01866.00.00.0
170.00.01866.00.0
180.00.00.01866.0
190.00.01866.00.0
201051.0706.042.067.0
21295.25572.25429.25569.25
22429.25518.25454.25464.25
PFM
ACGT
010.2080.2630.2970.232
020.2060.1450.3460.303
030.0940.6840.1230.099
040.6410.160.1370.062
050.1580.6860.0740.081
060.0760.1580.7110.056
070.0790.1130.1630.645
080.0730.0630.6830.182
090.2910.2510.2650.192
100.2440.2520.2680.235
110.2570.1870.3530.203
120.2810.1880.3890.142
130.0130.0070.4910.489
140.00.9990.0010.0
151.00.00.00.0
160.01.00.00.0
170.00.01.00.0
180.00.00.01.0
190.00.01.00.0
200.5630.3780.0230.036
210.1580.3070.230.305
220.230.2780.2430.249
PWM
ACGT
01-0.1850.0510.172-0.074
02-0.192-0.5410.3240.19
03-0.9681.004-0.703-0.924
040.939-0.446-0.597-1.38
05-0.4591.008-1.201-1.113
06-1.187-0.4561.042-1.487
07-1.146-0.793-0.4230.946
08-1.223-1.3711.002-0.318
090.1510.0050.059-0.261
10-0.0230.010.069-0.061
110.026-0.2890.344-0.207
120.116-0.2830.441-0.562
13-2.858-3.4490.6730.668
14-5.5161.383-5.09-5.516
151.383-5.516-5.516-5.516
16-5.5161.383-5.516-5.516
17-5.516-5.5161.383-5.516
18-5.516-5.516-5.5161.383
19-5.516-5.5161.383-5.516
200.810.413-2.368-1.917
21-0.4550.204-0.0830.198
22-0.0830.105-0.027-0.005
Standard thresholds
P-value Threshold
0.001 -0.19554
0.0005 1.46671
0.0001 4.99781